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Central and Peripheral Mechanisms of Cardiovascular Regulation pp 33–58Cite as

Ca Distribution and its Regulation in Smooth Muscle Cells

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Part of the book series: NATO ASI Series ((NSSA,volume 109))

Abstract

Although there exists an important variation between different smooth muscle cells, many common mechanisms can be presumed for the regulation of their excitation-contraction coupling. There is no doubt that the final step in the activation of smooth muscle, i.e. the force development depends on an interaction of the actin and myosin filaments. The main regulatory factor of this activity is the concentration of ionized calcium in the cytoplasm. From this point of view an analysis and an understanding of the regulation of the cytoplasmic Ca concentration is essential for the elucidation of the excitation-contraction coupling in these cells. However there is ample evidence in several cell types that Ca2+ is not the unique regulating factor and that other intracellular mediators as cAMP, cGMP and diacylglycerol can modulate the effect of varying cytoplasmic Ca concentrations. However the importance and the exact role of these intracellular messengers has not been sufficiently determined in smooth muscle cells.

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Authors and Affiliations

  1. Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, B-300, Leuven, Belgium

    J. Verbist, G. Droogmans, F. Wuytack & R. Casteels

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  1. J. Verbist
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  2. G. Droogmans
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  3. F. Wuytack
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  4. R. Casteels
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Editors and Affiliations

  1. Wadsworth Center for Laboratories and Research, Albany, New York, USA

    A. Magro

  2. University of Porto, Porto, Portugal

    W. Osswald

  3. Cornell University Medical College, New York, New York, USA

    D. Reis

  4. Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

    P. Vanhoutte

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Verbist, J., Droogmans, G., Wuytack, F., Casteels, R. (1986). Ca Distribution and its Regulation in Smooth Muscle Cells. In: Magro, A., Osswald, W., Reis, D., Vanhoutte, P. (eds) Central and Peripheral Mechanisms of Cardiovascular Regulation. NATO ASI Series, vol 109. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9471-0_2

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