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Organization of Differential Sympathetic Responses to Activation of Visceral Receptors and Arterial Baroreceptors

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Central and Peripheral Mechanisms of Cardiovascular Regulation

Part of the book series: NATO ASI Series ((NSSA,volume 109))

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Abstract

Cannon reasoned that the sympathetic nervous system is organized to produce “widespread changes in smooth muscle and glands throughout the organism” (Cannon, 1929; 1930). This diffuse action of the sympathetic system is possible because of its “arrangement for simultaneous and unified action.” Specifically, the extensive divergence of preganglionic inputs to postganglionic neurons as well as to secretory cells of the adrenal medulla would seem to ensure concordant physiological responses required to homeostatically regulate mammals’ internal environments during changes in the external environment. Cannon’s postulated “en masse” action of the sympathetic nervous system was strictly interpreted until thirty years later, when reports of non-uniform sympathetic responses began to appear in the literature. The concept of sympathetic mass-activation was first challenged by Folkow, Johansson, and Lofving (1961) and Lofving (1961). These investigators made simultaneous measurements of the reflex changes in blood flow to hindlimb muscle and skin, kidney, and intestine that were initiated by stimulation of arterial chemoreceptors or unloading of carotid arterial baroreceptors. In these studies, renal and cutaneous blood flows were relatively unaffected, whereas skeletal muscle vessels constricted in response to these stimuli; intestinal blood flow decreased less than skeletal muscle blood flow.

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Authors and Affiliations

  1. Department of Physiology, Michigan State University, 111 Giltner Hall, East Lansing, MI, 48824-1101, USA

    Lynne C. Weaver, Robert L. Meckler, Jean C. Tobey & Reuben D. Stein

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  1. Lynne C. Weaver
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  2. Robert L. Meckler
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  3. Jean C. Tobey
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  4. Reuben D. Stein
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Editors and Affiliations

  1. Wadsworth Center for Laboratories and Research, Albany, New York, USA

    A. Magro

  2. University of Porto, Porto, Portugal

    W. Osswald

  3. Cornell University Medical College, New York, New York, USA

    D. Reis

  4. Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

    P. Vanhoutte

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© 1986 Plenum Press, New York

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Weaver, L.C., Meckler, R.L., Tobey, J.C., Stein, R.D. (1986). Organization of Differential Sympathetic Responses to Activation of Visceral Receptors and Arterial Baroreceptors. In: Magro, A., Osswald, W., Reis, D., Vanhoutte, P. (eds) Central and Peripheral Mechanisms of Cardiovascular Regulation. NATO ASI Series, vol 109. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9471-0_10

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  • DOI: https://doi.org/10.1007/978-1-4615-9471-0_10

  • Publisher Name: Springer, Boston, MA

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