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Site Selection within the Host: Entry into Specific Organs and Cells

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Living Together

Abstract

For most parasites, entry into a suitable host is only a first step. They must then find their way to those particular parts of the host within which they can develop. There are many degrees of complexity, some parasites taking a rather direct route, others a roundabout one. Some are highly restricted to a certain location, such as a particular tissue or type of cell, whereas others are more catholic in their preferences. Parasites of the alimentary tract ingested through the mouth as cysts or as eggs or infective larvae, would seem to have the simplest and most direct path. Even here, however, there are preferred sites for localization. Thus, the infective larvae of the nematode parasite of mice, Nematospiroides dubius, enter with food, exsheathe in the stomach, and then lodge in the small intestine. Their specific site is in the region where bile enters and it has been shown experimentally that bile activates motility of the larvae and that they will accumulate to a much greater extent in bile than in water. Furthermore, if bile is surgically redirected in a living mouse to other than the normal region of the intestine, the larvae will establish in that region. Thus, bile can act not only in processes of excystation and hatching, but also at the next stage, in site selection. Most stimuli for site selection within the alimentary tract, however, are not well understood. It is becoming clear that even a tapeworm may exhibit a highly complex behavioral pattern.

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  1. The Rockefeller University, New York, New York, USA

    William Trager

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© 1986 Plenum Press, New York

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Trager, W. (1986). Site Selection within the Host: Entry into Specific Organs and Cells. In: Living Together. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9465-9_3

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  • DOI: https://doi.org/10.1007/978-1-4615-9465-9_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9467-3

  • Online ISBN: 978-1-4615-9465-9

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