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Characterisation of Human Platelet Adrenoceptors

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Mechanisms of Stimulus—Response Coupling in Platelets

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 192))

Abstract

In 1963 O’Brien was the first to document adrenaline induced aggregation in human platelets1. This functional response is not associated with the initial platelet shape change characteristic of the other agonists, and furthermore, full aggregation to adrenaline in vitro has only been observed for platelets obtained from some primates. Enhancement of aggregation by adrenaline to suboptimal concentrations of other agents (ie pro-aggregation) is seen in other animals as well as primates2, although the extent of even this response is quite variable amongst the species. Initial studies indicated that the adrenaline induced aggregatory response was mediated via an α-adrenoceptor on the platelet surface membrane, and in addition, the presence of β-adrenoceptors on mammalian platelets has been suggested by the anti-aggregatory effects of specific β-adrenergic agonist compounds3.

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Authors and Affiliations

  1. Department of Pharmacology & Therapeutics, University of Leicester, Leicester, UK

    D. B. Barnett, S. S. Swart, S. R. Nahorski & N. Cook

Authors
  1. D. B. Barnett
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  2. S. S. Swart
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  3. S. R. Nahorski
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  4. N. Cook
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons, London, England

    J. Westwick

  2. Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, England

    M. F. Scully  & V. V. Kakkar  & 

  3. Department of Pharmacology, University of Glasgow, Glasgow, Scotland

    D. E. MacIntyre

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© 1985 Plenum Press, New York

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Barnett, D.B., Swart, S.S., Nahorski, S.R., Cook, N. (1985). Characterisation of Human Platelet Adrenoceptors. In: Westwick, J., Scully, M.F., MacIntyre, D.E., Kakkar, V.V. (eds) Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9442-0_8

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  • DOI: https://doi.org/10.1007/978-1-4615-9442-0_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9444-4

  • Online ISBN: 978-1-4615-9442-0

  • eBook Packages: Springer Book Archive

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