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Mechanisms of Stimulus—Response Coupling in Platelets pp 41–54Cite as

Fibrinogen and Platelet Function

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 192))

Abstract

Formation of efficient plugs at sites of injury of a vessel wall is contingent upon modifications of the adhesive properties of the membrane of platelets. These alterations are generally accomplished via a multi steps mechanism encompassing: 1) adhesion and spreading of the cells to the subendothelial matrix; 2) activation of the platelet by specific agonists; and 3) interaction of the activated platelet with cofactors which modify the adhesive properties of the cell, to form aggregates. A number of biochemical events have been associated with this phenomenon. This includes calcium distribution, prostaglandin synthesis, actin polymerization, microtubules disassembly, and changes in adenylate cyclase activity. While these reactions have been identified their sequence and interrelationship in the transition reaction between a circulating and an aggregating platelet have yet to be delineated. It is well established, however that a specific stimulus and an exogenous cofactor with adhesive properties are necessary for aggregation to occur. Early studies on patients with congenital afibrinogenemia have provided evidences that fibrinogen fulfills the role of essential cofactor in this reaction. Platelets from these patients fail to aggregate or aggregate weakly in response to ADP or epinephrine and normal aggregation is restored upon addition of fibrinogen in the plasma of these patients.

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References

  1. G. A. Marguerie, E. F. Plow and T. S. Edgington. Human platelets possess an inducible and saturable receptor specific for fibrinogen. J. Biol. Chem., 254, 5357–5363, (1979).

    CAS  Google Scholar 

  2. J. S. Bennett and G. Vilaire. Exposure of platelet fibrinogen receptors by ADP and epinephrine. J. Clin. Invest., 64, 1393–1401, (1979).

    Article  CAS  Google Scholar 

  3. G. A. Marguerie, T. S. Edgington and E. F. Plow. Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation. J. Biol. Chem., 255, 154–161, (1980).

    CAS  Google Scholar 

  4. G. A. Marguerie, N. Thomas-Maison, M. J. Larrieu and E. F. Plow. The interaction of fibrinogen with human platelets in a plasma milieu. Blood, 59, 91–95, (1982).

    CAS  Google Scholar 

  5. G. A. Marguerie and E. F. Plow. (1983) The fibrinogen dependent pathway of platelet aggregation. Ann. N.Y. Acad. Sci., 408, 556–566, (1983).

    Google Scholar 

  6. L. S. Jennings and D. R. Phillips. Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex. J. Biol. Chem., 257, 10458–10466, (1982).

    CAS  Google Scholar 

  7. K. Fujimura and D. R. Phillips. Calcium cation regulation of glycoprotein IIb-IIIa complex formation in platelet membranes. J. Biol. Chem., 258, 10247–10252, (1983).

    CAS  Google Scholar 

  8. A. T. Nurden and J. P. Caen. An abnormal platelet glycoprotein pattern in three cases of Glanzman’s thrombasthenia. Br. J. Haematol., 28, 233–253, (1974).

    Article  Google Scholar 

  9. B. S. Coller, E. I. Peerschke, L. E. Scudder and C. A. Sullivan. A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa. J. Clin. Invest., 72, 278–286, (1983).

    Article  Google Scholar 

  10. H. Lee, A. T. Nurden, A. Thomaidis and J. P. Caen. Relationship between fibrinogen binding and the platelet glycoprotein deficiencies in Glanzmann’s thrombasthenia Type I and Type II. Br. J. Haematol., 48, 47–57, (1981).

    Article  CAS  Google Scholar 

  11. R. P. McEver, N. L. Baetziger and P. W. Majerus. Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J. Clin. Invest., 66, 1311–1318, (1980).

    Article  CAS  Google Scholar 

  12. G. O. Gogstad, F. Brosstad, M. B. Krutnes, L. Hagen and N. O. Solum. Fibrinogen-binding properties of the human platelet glycoprotein IIb-IIIa complex: A study using crossed-radio-immunoelectrophoresis. Blood, 60, 663–671, (1982).

    CAS  Google Scholar 

  13. R. L. Nachman and L. L. K. Leung. Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen. J.Clin.Invest, 69, 263–269, 1982.

    Article  CAS  Google Scholar 

  14. M. H. Ginsberg, J. Forsyth, A. Lightsey, J. Chediak and E. F. Plow. Reduced surface expression and binding of fibronectin by thrombin-stimulated thrombasthenic platelets. J. Clin. Invest., 71, 619–624, (1983).

    Article  CAS  Google Scholar 

  15. Z. M. Ruggeri, R. Bader and L. De Marco. Glanzmann thrombasthenia: deficient binding of von Willebrand factor to thrombin-stimulated platelets. Proc. Natl Acad. Sci. USA, 79, 6038–6041, (1982).

    Article  CAS  Google Scholar 

  16. J. S. Bennett, G. Vilaire and D. B. Cines. Identification of the fibrinogen receptor on human platelet by photoaffinity labeling. J.Biol.Chem., 257, 8049–8054, (1982).

    CAS  Google Scholar 

  17. G. A. Marguerie, N. Thomas-Maison, M. H. Ginsberg and E. F. Plow. The platelet fibrinogen interaction, evidences for proximity of the A chain fibrinogen to platelet membrane glycoprotein IIb/III. Eur. J. Biochem. 139, 5–11, (1977).

    Article  Google Scholar 

  18. S. Niewiarowski, A. Z. Budzynski and B. Lipinski. Significance of the intact polypeptide chains of human fibrinogen in ADP-induced platelet aggregation. Blood, 49, 635–644, (1977).

    CAS  Google Scholar 

  19. G. A. Marguerie, N. Ardaillou, G. Cherel and E. F. Plow. The binding of fibrinogen to its platelet receptor: Involvement of the D domain. J. Biol. Chem., 257, 11872–11875, (1982).

    CAS  Google Scholar 

  20. M. Kloczewiak, S. Timmons, T. J. Lukas, J. Hawiger. Platelet recognition site on human fibrinogen. Synthesis and structure relationship of peptides corresponding to the carboxyterminal segment of the chain. Biochemistry, 23, 1767–1774, (1984).

    Article  CAS  Google Scholar 

  21. E. F. Plow, A. H. Srouji, D. Meyer, G. A. Marguerie and M. H. Ginsberg. Evidence that three adhesive proteins interact with a common recognition site on activated platelets. J. Biol. Chern., 259, 5388–5381, (1984).

    CAS  Google Scholar 

  22. J. Hawiger, S. Timmons, M. Kloczewiak, D. D. Strong and R. F. Doolittle. and chains of human fibrinogen possess sites reactive with human platelet receptors. Pore. Natl Acad.Sci. USA, 79, 2068–2071 (1982)

    Article  CAS  Google Scholar 

  23. P. Ganguly. Isolation and some properties of fibrinogen from human blood platelets. J.Biol.Chem., 247, 1809–1816 (1972).

    CAS  Google Scholar 

  24. P. A. Castaldi and J. Caen. Platelet fibrinogen. J.Clin.Pathol., 18, 579–585 (1965).

    Article  CAS  Google Scholar 

  25. M. Jandrot-Perrus, M. W. Mosesson, M. H. Denninger, D. Ménaché. Studies of platelet fibrinogen from a subject with a congenital plasma fibrinogen abnormality (fibrinogen Paris I). Blood, 54, 1109–1114 (1979).

    CAS  Google Scholar 

  26. I. Soria, C. Soria, M. Samama, E. Poirot, C. Kling. Human platelet fibrinogen. A protein different from plasma fibrinogen. Pathol.Biol., 24, 15 (1976) abstr.

    Google Scholar 

  27. M.W. Mosesson, G. A. Howardberg, D. L. Amrani. Human platelet fibrinogen gamma chain structure. Blood, 63, 990–995 (1984).

    CAS  Google Scholar 

  28. C. W. Francis, R. L. Nachman, V. J. Marder. Plasma and platelet fibrinogen differ in chain content. Thromb.Haemost., 51, 84–88 (1984).

    CAS  Google Scholar 

  29. K. L. Kaplan, M. J. Dauzier, S. Rose. ADP and epinephrine induced release of platelet fibrinogen. Blood, 58, 797–802 (1981).

    CAS  Google Scholar 

  30. R. A. F. Clark, J. Lanigan, H. F. Dvorak, R.B. Colvin. Expression of platelet membrane fibrinogen correlates with platelet spreading and is not sufficient for platelet aggregation. Clin.Res., 28, 307 A (1981).

    Google Scholar 

  31. G. Courtois, J. J. Rickewaert, M. H. Ginsberg, E. F. Plow, G. Marguerie. Surface exposure of intracellular fibrinogen on stimulated platelets. Submitted (1984).

    Google Scholar 

  32. E. F. Plow, G. Marguerie, M. H. Ginsberg. Expression and function of adhesive proteins of the platelet surface. In: The Biology of Platelets. D.K. Phillips and M.A. Shuman Eds, (1984) in press.

    Google Scholar 

  33. M. H. Ginsberg, J. Forsyth, A. Lightsey, J. Chediak, E. F. Plow. Reduced surface expression and binding of fibronectin by thrombin stimulated thrombasthenic platelets. J.Clin.Invest, 71, 619–624 (1983).

    Article  CAS  Google Scholar 

  34. Z.M. Ruggeri, R. Bader and L. De Marco. Glanzmann thrombasthenia deficient binding of von Willebrand factor to thrombin: stimulated platelets. Proc.Natl Acad.Sci.USA, 79, 6038–6041 (1982).

    Article  CAS  Google Scholar 

  35. G. Pietu, G. Cherel, G. Marguerie and D. Meyer. Inhibition of von Willebrand factor platelet interaction by fibrinogen. Nature, 308, 648–649 (1984).

    Article  CAS  Google Scholar 

  36. E.F. Plow, R. McEver, B. Coller, V.L. Woods Jr, G. Marguerie and M.H. Ginsberg. Platelet adhesive proteins shares a common binding mechanism on thrombin-stimulated platelets. Submitted (1984).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Institut de Pathologie Cellulaire INSERM U 143, Paris, France

    Gérard A. Marguerie

  2. Research Institute of Scripps Clinic La Jolla, CA, USA

    Mark. H. Ginsberg & Edward F. Plow

Authors
  1. Gérard A. Marguerie
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  2. Mark. H. Ginsberg
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  3. Edward F. Plow
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons, London, England

    J. Westwick

  2. Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, England

    M. F. Scully  & V. V. Kakkar  & 

  3. Department of Pharmacology, University of Glasgow, Glasgow, Scotland

    D. E. MacIntyre

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© 1985 Plenum Press, New York

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Marguerie, G.A., Ginsberg, M.H., Plow, E.F. (1985). Fibrinogen and Platelet Function. In: Westwick, J., Scully, M.F., MacIntyre, D.E., Kakkar, V.V. (eds) Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9442-0_4

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  • DOI: https://doi.org/10.1007/978-1-4615-9442-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9444-4

  • Online ISBN: 978-1-4615-9442-0

  • eBook Packages: Springer Book Archive

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