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Adenosine Diphosphate as a Mediator of Platelet Aggregation in Vivo

  • Chapter
Mechanisms of Stimulus—Response Coupling in Platelets

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 192))

Abstract

When blood vessels are injured so that they bleed, circulating platelets adhere to the damaged vessel walls and aggregate, so diminishing or arresting the haemorrhage. This interaction between platelets and vessel walls therefore has an easily demonstrable physiological function. There is much clinical and experimental evidence that a deficiency or defect in circulating platelets is associated with ‘spontaneous’ haemorrhages from small vessels. This suggests that platelets are somehow essential for the functional integrity of these vessels, but if there is such a mechanism it has still to be established.

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References

  1. von Rokitansky, Handbuch der pathologischen Anatomie, Braumuller & Seidel, Vienna, (1941).

    Google Scholar 

  2. J.B. Duguid, Pathogenesis of atherosclerosis, Lancet 2, 925 (1949).

    Article  CAS  Google Scholar 

  3. J.F. Mustard, M.A. Packham and R.L. Kinlough-Rathbone, Platelets, thrombosis and atherosclerosis, Proc. Biochem. Pharmacol. 13:312 (1977a).

    CAS  Google Scholar 

  4. R. Ross and J.A. Glomset, Atherosclerosis and the arterial smooth muscle cell. Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis, Science (Wash. DC) 180:1332 (1973).

    Article  CAS  Google Scholar 

  5. K.W. Walton, Pathogenetic mechanisms in atherosclerosis, Am. J. Cardiol. 35:542 (1975).

    Article  CAS  Google Scholar 

  6. H. Kortenhaus, Schroer and G.V.R. Born, Quantification of the adhesion of platelets in hamster venules in vivo, Proc. R. Soc. Lond. B, 215:135 (1982).

    Article  CAS  Google Scholar 

  7. R.L. Nachman, The platelet as an inflammatory cell. in: “Platelets: a multidisciplinary approach”, G. de Gaetano & S. Garattini, eds., pp.199, New York, Raven Press, (1978).

    Google Scholar 

  8. H.P. Payling-Wright and G.V.R. Born, Possible effect of blood flow on the turnover rate of vascular endothelial cells, in: “Therotical and clinical haemorheology”, H.H. Hartet & A.L. Copley, eds., Springer-Verlag, Berlin, pp.220 (1971).

    Chapter  Google Scholar 

  9. H.P. Payling-Wright, Mitosis patterns in aortic endothelium, Atherosclerosis 15:93 (1972).

    Article  Google Scholar 

  10. W.E. Stehbens, Endothelial cell mitosis and permeability, J. Exp. Physiol. (Cogn. Med. Sci.) 50:90 (1965).

    CAS  Google Scholar 

  11. C.G. Caro, Mechaincal factors in atherogenesis, in: “Cardiovascular flow dynamics and measurement”, University Park Press, Baltimore, (1977).

    Google Scholar 

  12. M.J. Davies and T. Thomas, The pathological basis and microanatomy of occlusive thrombus formation in human coronary arteries, Phil. Trans. R. Soc. Lond. B, 294:225 (1981).

    Article  CAS  Google Scholar 

  13. G.V.R. Born, Arterial thrombosis and its prevention (Proc. VIII World Congr. Cardiol., Tokyo 1978), Excerpta Medica, Amsterdam, ICS 470, p.81.

    Google Scholar 

  14. H. Friedman, Pathogenesis of coronary thrombosis, intramural and intraluminal haemorrhage, in: “Thrombosis and coronary heart disease”, L.A. Halonen, ed., Karger, Basel, vol.4:3 (1979).

    Google Scholar 

  15. G.V.R. Born and P.D. Richardson, Activation time of blood platelets, Proc. R. Soc. Lond. B Biol. Sci, (1979).

    Google Scholar 

  16. G.D. Wilner, Pathogenetic mechanisms in atherosclerosis, Am. J. Cardiol. 35:542 (1975).

    Article  Google Scholar 

  17. P.D. Richardson, P. Gaietti and G.V.R. Born, Regional administration of drugs to control thrombosis in artificial organs, Trans. Am. Soc. Artif. Intern. Organs 22:22 (1976).

    CAS  Google Scholar 

  18. G.V.R. Born, Fluid-mechanical and biochemical interactions in haemostasis, Br. Med. Bull. 33:193 (1977).

    CAS  Google Scholar 

  19. J.W.S. Pringle, Stretch activation of muscle: Function and mechanism, The Croomian Lecture 1977, The Royal Society, London, UK, (1978).

    Google Scholar 

  20. H. Feinberg, W.C. Sandler, M. Scorer, G.C. Le Breton, B. Grossman and G.V.R. Born, Movement of sodium into human platelets induced by ADP, Biochem. Biophys. Acta. 470:317 (1977).

    Article  CAS  Google Scholar 

  21. R. Kaser-Glanzmann, M. Jakabova, J.N. George and E.F. Luscher, Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3′, 5′-cyclic monophosphate and protein kinase, Biochem. Biophys. Acta 466:429 (1977).

    Article  CAS  Google Scholar 

  22. C.G. LeBreton, W.C. Sandler and H. Feinberg, The effect of D2O and Chlortetracycline on ADP-induced platelet shapoe change and aggregation, Thrombos. Res. 8:477 (1976).

    Article  CAS  Google Scholar 

  23. G.V.R. Born and M.J. Cross, Effects of inorganic ions and of plasma proteins on the aggregation of blood platelets by adenosine diphosphate, J. Physiol. (Lond) 170:394 (1964).

    Google Scholar 

  24. M.J. Cross, Effect of fibrinogen on the aggregation of platelets by adenosine diphosphate, Thromb. Diath. Haemorrh. 12:524 (1964).

    CAS  Google Scholar 

  25. G.V.R. Born, Observations on the change in shape of blood platelets brought about by adenosine diphosphate, J. Physiol. 209:487 (1970).

    CAS  Google Scholar 

  26. K.E. Arfors, J.S. Cockburn abd J.F. Gross, Measurement of growth rate of laser-induced intravascular platelet aggrewgation, and the influence of blood flow velocity, Microvasc. Res. 11:79 (1976).

    Article  CAS  Google Scholar 

  27. N.A. Begent and G.V.R. Born, Growth rate in vivo of platelet thrombi produced by iontophoresis of ADP, as a function of mean blood flow velocity, Nature (Lond) 227:926 (1970).

    Article  CAS  Google Scholar 

  28. P.D. Richardson, Effect of blood flow velocity on growth rate of platelet thrombi, Nature (Lond) 245:103 (1973).

    Article  CAS  Google Scholar 

  29. K.M. Zawilska, G.V.R. Born and N.A. Begent, Effect of ADP-utilizing enzymes on the arterial bleeding time in rats and rabbits, Brit. J. Haematol. 50:317 (1982).

    Article  CAS  Google Scholar 

  30. G. Forster, E. Bernt and H.V. Bergmeyer, Creatine kinase, Methods of enzymatic analysis, ed., H.V. Bergmeyer, vol. 2 pp.784, Academic Press, New York, (1974).

    Google Scholar 

  31. D. Bergqvist and K.E. Arfors, Influence of platelet count on haemostatic plug formation and plug stability, An experimental study in rabbits with graded thrombocytopenia, Thromb. et Diathes. Haemorr .30:586 (1973).

    CAS  Google Scholar 

  32. R.J. Haslam and D.C.B. Mills, The adenylate kinase of human plasma, erythrocytes and platelets in relation to degradation of adenosine diphosphate in plasma, Biochem. J. 103:773 (1967).

    CAS  Google Scholar 

  33. J.W. De-Pierre and M.L. Karnovsky, Plasma membranes of mammalian cells. A review of methods for their characterisation and isolation, J. Cell Biol. 56:275 (1973).

    Article  CAS  Google Scholar 

  34. J.F. Manery and E.E. Dryden, Ecto-enzymes concerned with nucleotide metabolism. Physiological and Regulatory functions of adenosine and adenine nucleotides, eds., H.P. Baer & G.I. Drummond, pp.323, Raven Press, New York, (1979).

    Google Scholar 

  35. B. Nunn and P.D. Chamberlain, Further evidence against the validity of using an ADP-removing enzyme system (CP/CPK) for demonstrating the role of secreted ADP in platelet activation, Thromb. Res. 30:19 (1983).

    Article  CAS  Google Scholar 

  36. E.M. Huang and T.C. Detwiler, Reassessment of the evidence for the role of secreted ADP in biphasic platelet aggregation, J. Lab. Clin. Med. 95:59 (1980).

    CAS  Google Scholar 

  37. D. Bergqvist and K.E. Arfors, Haemostatic platelet plug formation in the isolated rabbit mesenteric preparation — an analysis of red blood cell participation, Thrombos. Haemostas. 4:6 (1980).

    Google Scholar 

  38. G.V.R. Born, D. Bergqvist and K.E. Arfors, Evidence for inhibition of platelet activation in blood by drug effect on erythrocytes, Nature 259:233 (1976).

    Article  CAS  Google Scholar 

  39. J.F. Mustard, D.W. Perry, N.G. Ardlie and M.A. Packham, Preparation of suspension of washed platelets from humans, Brit. J. Haematol. 22:193 (1972).

    Article  CAS  Google Scholar 

  40. K. Zawilska, V. Izrael, N. Chelloul and J. Caen, Prevention de la coagulation intravasculaire disseminee au course du Phenomemene de Schwartzmann generalise chez le lapin par un system enzymatic consommant I’ADP plasmatique, Actualitees Hematologiques, 9:269 (1975).

    CAS  Google Scholar 

  41. G.V.R. Born and M.D.A. Kratzer, Source and quantification of extracellular adenosine triphosphate during haemostasis in rats, rabbits and man, J. Physiol. Lond. 354 (1984).

    Google Scholar 

  42. G.V.R. Born, Aggregation of blood platelets by adenosine diphosphate and its reversal, Nature 194:927 (1962).

    Article  CAS  Google Scholar 

  43. G.V.R. Born, Arterial thrombosis and its prevention, Proceedings of VIIIth World Congress of Cardiology, ed., S. Hayase & S. Murao, pp.81, Excerpta Medica, Amsterdam (1979).

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, King’s College Strand, London, WC2R 2LS, UK

    G. V. R. Born

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  1. G. V. R. Born
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Editors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons, London, England

    J. Westwick

  2. Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, England

    M. F. Scully  & V. V. Kakkar  & 

  3. Department of Pharmacology, University of Glasgow, Glasgow, Scotland

    D. E. MacIntyre

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© 1985 Plenum Press, New York

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Born, G.V.R. (1985). Adenosine Diphosphate as a Mediator of Platelet Aggregation in Vivo. In: Westwick, J., Scully, M.F., MacIntyre, D.E., Kakkar, V.V. (eds) Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9442-0_28

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  • DOI: https://doi.org/10.1007/978-1-4615-9442-0_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9444-4

  • Online ISBN: 978-1-4615-9442-0

  • eBook Packages: Springer Book Archive

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