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Mechanisms of Stimulus—Response Coupling in Platelets pp 145–162Cite as

Control and Interrelation of Aggregation and Secretion; the Roles of Ca2+, Diacylglycerol and Thromboxane with Particular Reference to ADP Stimulation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 192))

Abstract

In this article we propose to outline our present understanding of the intracellular pathways regulating aggregation and secretion in human platelets, and the various ways in which secretion and aggregation may be independent or interdependent under different experimental conditions. We shall also consider briefly shape-change and its relation to aggregation and secretion.

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Author information

Author notes

  1. T. J. Rink

    Present address: Smith Kline & French Research Limited, The Frythe, Welwyn, Herts., AL6 9AR, UK

Authors and Affiliations

  1. Physiological Laboratory, Cambridge University, Downing Street, Cambridge, CB2 3EG, UK

    T. J. Hallam, A. W. M. Simpson, N. O’Connor & T. J. Rink

Authors
  1. T. J. Hallam
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  2. A. W. M. Simpson
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  3. N. O’Connor
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  4. T. J. Rink
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons, London, England

    J. Westwick

  2. Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, England

    M. F. Scully  & V. V. Kakkar  & 

  3. Department of Pharmacology, University of Glasgow, Glasgow, Scotland

    D. E. MacIntyre

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© 1985 Plenum Press, New York

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Hallam, T.J., Simpson, A.W.M., O’Connor, N., Rink, T.J. (1985). Control and Interrelation of Aggregation and Secretion; the Roles of Ca2+, Diacylglycerol and Thromboxane with Particular Reference to ADP Stimulation. In: Westwick, J., Scully, M.F., MacIntyre, D.E., Kakkar, V.V. (eds) Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9442-0_11

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  • DOI: https://doi.org/10.1007/978-1-4615-9442-0_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9444-4

  • Online ISBN: 978-1-4615-9442-0

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