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Agonist-Induced Inositol Phospholipid Metabolism and Ca++ Flux in Human Platelet Activation

  • Chapter
Mechanisms of Stimulus—Response Coupling in Platelets

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 192))

Abstract

Human platelet responsiveness may be modulated by a variety of agonists that combine with specific receptors on the platelet plasma membrane. Receptors for Thrombin, ADP, Thromboxane (Tx) A2, Platelet activating factor (PAF), Vasopressin (VP). Adrenaline, Prostaglandin (PG) I2, PGD2 and Adenosine, inter alia, have been identified by a variety of pharmacological techniques including radioligand binding analyses, homologous desensitisation and the use of specific antagonists1,2. Platelets are electrically non-exciteable3. Thus in order for platelets to respond to externally applied (exogenous) agonists, there must exist some information transfer system whereby events at the cell surface influence the rates of the key biochemical reactions that actually mediate the cellular response. These key biochemical reactions are controlled by stimulus-induced changes in the intracellular concentrations of second messenger molecules including cAMP, cytosolic free Ca++ (Caf) and 1,2-diacylglycerol (DAG)4,5. These second messengers activate specific protein kinases, respectively cAMP-dependent protein kinase. Ca++-calmodulin-dependent protein kinase and protein kinase C6,7 that mediate the phosphorylation and altered reactivity of specific target proteins.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Glasgow, Glasgow, G12 8QQ, Scotland

    D. Euan MacIntyre, W. Kenneth Pollock, Angus M. Shaw, Mark Bushfield, Linda J. MacMillan & Archibald McNicol

Authors
  1. D. Euan MacIntyre
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  2. W. Kenneth Pollock
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  3. Angus M. Shaw
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  4. Mark Bushfield
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  5. Linda J. MacMillan
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  6. Archibald McNicol
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons, London, England

    J. Westwick

  2. Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, England

    M. F. Scully  & V. V. Kakkar  & 

  3. Department of Pharmacology, University of Glasgow, Glasgow, Scotland

    D. E. MacIntyre

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© 1985 Plenum Press, New York

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MacIntyre, D.E., Pollock, W.K., Shaw, A.M., Bushfield, M., MacMillan, L.J., McNicol, A. (1985). Agonist-Induced Inositol Phospholipid Metabolism and Ca++ Flux in Human Platelet Activation. In: Westwick, J., Scully, M.F., MacIntyre, D.E., Kakkar, V.V. (eds) Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9442-0_10

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  • DOI: https://doi.org/10.1007/978-1-4615-9442-0_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9444-4

  • Online ISBN: 978-1-4615-9442-0

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