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Longitudinal Assessment of Persistent Generalized Lymphadenopathy (PGL) in Homosexual Men

  • Usha Mathur-Wagh
  • Donna Mildvan
  • Ilya Spigland
  • Francoise Brun-Vezinet
  • Francoise Barre-Sinoussi
  • Luc Montagnier
  • Jean Claude Chermann
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)

Abstract

Since February, 1981, a cohort of 42 homosexual or bisexual men with persistent generalized lymphadenopathy (PGL) has been followed longitudinally at the Beth Israel Medical Center (BIMC), with periodic clinical, virologic and immunologic evaluations. We defined the syndrome of PGL in homosexual and bisexual men (1,2) by the presence of: a) lymph nodes of greater than 1 cm size, of more than 3 months duration, involving at least 2 extrainguinal anotomic sites; b) absence of symptomatic infection at the onset of lymphadenopathy; c) absence of an apparent etiology such as history of intravenous drug abuse, dilantin therapy, recent immunization, skin rash or evidence of neoplastic disease, and d) absence of unexplained weight loss, diarrhea, thrush or evidence of other opportunistic infections or cancers. A detailed description of the epidemiologic, clinical and laboratory findings of this group has been previously reported (3).

Keywords

Pneumocystis Carinii Pneumonia Immune Deficiency Syndrome Seropositive Patient Intravenous Drug Abuse Dilantin Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Mildvan D, Mathur U, Enlow RW, et al. Persistent generalized lymphadeno pathy among homosexual males. CDC: Morbid. Mortal. Wkly. Rep. 1982; 31: 249 251.Google Scholar
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    Mathur U, Enlow RW, Spigland I, William DC, Winchester RJ, Mildvan D. Generalized lymphadenopathy: A prodrome of Kaposi’s sarcoma in male homosexuals? Abstract presented at the 22nd Interscience Conference on Antimicrobial Agents and chemotherapy, Miami Beach, Florida, October 1982.Google Scholar
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    Mathur-Wagh U, Enlow RW, Spigland I, Longitudinal study of persistent generalized lymphadenopathy (PGL) in homosexual men: relationship to the acquired immune deficiency syndrome. Lancet 1984; 1033–38.Google Scholar
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Usha Mathur-Wagh
    • 1
  • Donna Mildvan
    • 1
  • Ilya Spigland
    • 2
  • Francoise Brun-Vezinet
    • 3
  • Francoise Barre-Sinoussi
    • 4
  • Luc Montagnier
    • 4
  • Jean Claude Chermann
    • 4
  1. 1.The Department of Medicine, Beth Israel Medical CenterThe Mount Sinai School of Medicine of the City University of New YorkNew YorkUSA
  2. 2.Division of Virology, Montefiore Hospital and Medical CenterAlbert Einstein College of MedicineBronxUSA
  3. 3.Laboratoire de VirologieHôpital Claude BernardParisFrance
  4. 4.Unite d’Oncologie ViraleInstitut PasteurParisFrance

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