Role of Epstein-Barr Virus in Acquired Immune Deficiency Syndrome

  • David T. Purtilo
  • Helen Kipscomb
  • Gerhard Krueger
  • Joseph Sonnabend
  • Dominic Casareale
  • David J. Volsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)


Human lymphotropic viruses including human T cell leukemia virus-III (HTLV-III), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) likely serve important etiological roles in the induction of the acquired immune deficiency syndrome (AIDS) and in the AIDS-related malignancies. By infecting the cellular components of the immune system, these viruses alter the balance between the various lymphocyte subpopulations and affect immune regulation as well.1–3 HTLV-III is thought to be important in the induction of AIDS, especially for the final stages in the pathogenesis, owing to infection and lysis of T helper cells. CMV and EBV have been implicated in the induction of both benign and malignant disorders in patients with AIDS, including Kaposi’s sarcoma and malignant B cell lymphoma, respectively.4


Acquire Immune Deficiency Syndrome Infectious Mononucleosis Immune Deficiency Syndrome Male Homosexual Acquire Immune Deficiency Syndrome Patient 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • David T. Purtilo
    • 1
    • 2
    • 3
  • Helen Kipscomb
    • 1
    • 3
  • Gerhard Krueger
    • 4
  • Joseph Sonnabend
    • 5
  • Dominic Casareale
    • 1
  • David J. Volsky
    • 1
    • 3
  1. 1.Department of Pathology and Laboratory MedicineThe University of Nebraska Medical CenterUSA
  2. 2.PediatricsThe University of Nebraska Medical CenterUSA
  3. 3.The Eppley Institute for Research in Cancer and Allied DiseasesOmahaUSA
  4. 4.Immunopathology Laboratories, Pathology InstituteUniversity of Cologne, Clinical Center LindenburgWest Germany
  5. 5.New YorkUSA

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