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Role of Epstein-Barr Virus in Acquired Immune Deficiency Syndrome

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AIDS-Associated Syndromes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 187))

Abstract

Human lymphotropic viruses including human T cell leukemia virus-III (HTLV-III), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) likely serve important etiological roles in the induction of the acquired immune deficiency syndrome (AIDS) and in the AIDS-related malignancies. By infecting the cellular components of the immune system, these viruses alter the balance between the various lymphocyte subpopulations and affect immune regulation as well.1–3 HTLV-III is thought to be important in the induction of AIDS, especially for the final stages in the pathogenesis, owing to infection and lysis of T helper cells. CMV and EBV have been implicated in the induction of both benign and malignant disorders in patients with AIDS, including Kaposi’s sarcoma and malignant B cell lymphoma, respectively.4

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Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, The University of Nebraska Medical Center, USA

    David T. Purtilo, Helen Kipscomb, Dominic Casareale & David J. Volsky

  2. Pediatrics, The University of Nebraska Medical Center, USA

    David T. Purtilo

  3. The Eppley Institute for Research in Cancer and Allied Diseases, 42nd and Dewey Avenue, Omaha, Nebraska, 68105, USA

    David T. Purtilo, Helen Kipscomb & David J. Volsky

  4. Immunopathology Laboratories, Pathology Institute, University of Cologne, Clinical Center Lindenburg, 5000, Cologne 41, West Germany

    Gerhard Krueger

  5. 49 West 12 Street, New York, New York, 10011, USA

    Joseph Sonnabend

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  1. David T. Purtilo
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  2. Helen Kipscomb
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  4. Joseph Sonnabend
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  1. California College of Medicine, University of California, Irvine, California, USA

    Sudhir Gupta

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© 1985 Plenum Press, New York

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Purtilo, D.T., Kipscomb, H., Krueger, G., Sonnabend, J., Casareale, D., Volsky, D.J. (1985). Role of Epstein-Barr Virus in Acquired Immune Deficiency Syndrome. In: Gupta, S. (eds) AIDS-Associated Syndromes. Advances in Experimental Medicine and Biology, vol 187. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9430-7_5

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  • DOI: https://doi.org/10.1007/978-1-4615-9430-7_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9432-1

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