Lymphadenopathy Associated Virus (L.A.V.) : Its Association with AIDS or Prodromes

  • Françoise Barré-Sinoussi
  • Jean-Claude Chermann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)


In testing the hypothesis that retroviruses could be involved in AIDS or AIDS related complexe (ARC), we isolated in 1983 a T lymphotropic retrovirus from a homosexual man presenting with lymphadenopathy ( 1 ) . This virus was shown to be a retrovirus by all classical criteria (density in sucrose gradient, high molecular weight RNA, reverse transcriptase activity, morphogenesis by budding) ( 2 )( 3 ). This first isolate was named Lymphadenopathy Associated Virus (LAV 1). Latter on similar viruses were obtained by our group ( 4 )( 5 )( 6 ) and by others from patients with AIDS or related symptoms ( 7 ) ( 8 ) ( 9 ).


Acquire Immunodeficiency Syndrome Reverse Transcriptase Activity AIDS Related Complexe Sodium Hypochloride Release Virus Particle 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Françoise Barré-Sinoussi
    • 1
  • Jean-Claude Chermann
    • 1
  1. 1.Unité d’Oncologie ViraleInstitut PasteurParis Cédex 15France

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