Etiology of AIDS: Biological and Biochemical Characteristics of HTLV-III

  • Phillip D. Markham
  • George M. Shaw
  • S. Zaki Salahuddin
  • Beatrice Hahn
  • M. G. Sarngadharan
  • Robert C. Gallo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)


The human T-cell leukemia (lymphotropic) viruses comprise a group of retroviruses which share several structural, biochemical, and biological properties, and have been collectively named HTLV in accordance with guidelines established by a group of scientists at an international conference on human retroviruses (19, 79). The properties shared by all known members of the HTLV group include; 1) tropism for T-lymphocytes, 2) a high molecular weight, Mg+−preferring reverse transcriptase, 3) similar size, number and genomic organization of major core proteins, 4) cytopathic effect on infected cells, 5) prevalence of 3′ terminal gene, Lor, and double splicing mechanisms coding for a transactivating protein, 6) distant antigenic and nucleic acid relatedness, and 7) a likely African origin.


Long Terminal Repeat Acquire Immune Deficiency Syndrome Bovine Leukemia Virus Equine Infectious Anemia Virus Acquire Immune Deficiency Syndrome Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Phillip D. Markham
    • 1
  • George M. Shaw
    • 1
  • S. Zaki Salahuddin
    • 1
  • Beatrice Hahn
    • 1
  • M. G. Sarngadharan
    • 1
  • Robert C. Gallo
    • 1
  1. 1.Laboratory of Tumor Cell Biology, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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