The Mechanism and Modulation of Immune Dysfunction in AIDS Associated Syndromes

  • J. George Bekesi
  • Peter Tsang
  • Julia P. Roboz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)


Acquired immunodeficiency syndrome (AIDS) is an acute disease which is characterized by a profound dysfunction of cell mediated immunity including severe anergy,1 marked reduction in the number of T-helper cells,1, 2, 3, 4, 5 an apparent inversion of T-helper to T-suppressor cell ratio2, 4, 5 and reduced natural killer cell function.6, 7, 8, 9 Most patients were reported to have increased levels of serum immunoglobulins.3, 4, 6, 7, 8, 10 Also, high titers of antibodies have been reported to cytomegalovirus (CMV), Epstein Barr Virus (EBV), and hepatitis virus.11, 12, 13, 14 The group considered to be at highest risk to develop AIDS are homosexual men some of whom are often promiscuous.15


Acquire Immune Deficiency Syndrome Lymphocyte Function Natural Killer Cell Function Heterosexual Male Acquire Immune Deficiency Syndrome Patient 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • J. George Bekesi
    • 1
  • Peter Tsang
    • 1
  • Julia P. Roboz
    • 1
  1. 1.Dept. Neoplastic DiseasesMount Sinai School of MedicineNew YorkUSA

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