Expression of Beta 2 Microglobulin on the Surface of Mononuclear Cells in Patients with Acquired Immune Deficiency Syndrome (AIDS) and Aids-Related Complex (ARC)

  • Sudhir Gupta
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)


Beta 2 microglobulin (B2-m) is a low molecular weight protein of 11,800 daltons and contains 100 amino acids. It was originally isolated from human urine and has been found in all body fluids (1–3). B2-m shows a homology with CH3 domain of immunoglobulin molecules and is associated with class I major histocompatibility complex molecules. B2-m is present on the surface of and synthesized by virtually all somatic cells. In vitro, both normal and malignant human cell lines and activated normal lymphocytes synthesize B2-m (4, 5). B2-m has been shown to play a role in T cell response to mitogens, soluble antigens and alloantigens (6–12). Acquired immune deficiency syndrome (AIDS) is characterized by several defects of T cell functions and clinically manifested by opportunistic infections and/or Kaposi’s sarcoma (KS) (13–16). Recently, increased plasma levels of B2-m in patients with AIDS and hemophilia have been described (17–19). In this study we have examined the expression of surface B2-m on the mononuclear cells (MNC) from patients with AIDS and AIDS-related complex (ARC), using a monoclonal antibody and fluorescence- activated cell sorter analyzer (20).


Acquire Immune Deficiency Syndrome Acquire Immunodeficiency Syndrome Major Histocompatibility Complex Molecule Autologous Mixed Lymphocyte Reaction Human Monocyte Cell Line 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Sudhir Gupta
    • 1
  1. 1.Division of Basic and Clinical ImmunologyUniversity of CaliforniaIrvineUSA

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