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Expression of Beta 2 Microglobulin on the Surface of Mononuclear Cells in Patients with Acquired Immune Deficiency Syndrome (AIDS) and Aids-Related Complex (ARC)

  • Sudhir Gupta
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)

Abstract

Beta 2 microglobulin (B2-m) is a low molecular weight protein of 11,800 daltons and contains 100 amino acids. It was originally isolated from human urine and has been found in all body fluids (1–3). B2-m shows a homology with CH3 domain of immunoglobulin molecules and is associated with class I major histocompatibility complex molecules. B2-m is present on the surface of and synthesized by virtually all somatic cells. In vitro, both normal and malignant human cell lines and activated normal lymphocytes synthesize B2-m (4, 5). B2-m has been shown to play a role in T cell response to mitogens, soluble antigens and alloantigens (6–12). Acquired immune deficiency syndrome (AIDS) is characterized by several defects of T cell functions and clinically manifested by opportunistic infections and/or Kaposi’s sarcoma (KS) (13–16). Recently, increased plasma levels of B2-m in patients with AIDS and hemophilia have been described (17–19). In this study we have examined the expression of surface B2-m on the mononuclear cells (MNC) from patients with AIDS and AIDS-related complex (ARC), using a monoclonal antibody and fluorescence- activated cell sorter analyzer (20).

Keywords

Acquire Immune Deficiency Syndrome Acquire Immunodeficiency Syndrome Major Histocompatibility Complex Molecule Autologous Mixed Lymphocyte Reaction Human Monocyte Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Sudhir Gupta
    • 1
  1. 1.Division of Basic and Clinical ImmunologyUniversity of CaliforniaIrvineUSA

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