Abstract
Cholesterol monohydrate (CHM) is present in human gallstones[1] and in arterial wall[2], Bile salt-induced cholesterol gallstone dissolution is a recent advance in clinical medicine: chenodeoxycholic acid (CDCA)[3] and its epimer, ursodeoxycholic acid (UDCA)[4] reduce the relative amount of cholesterol in human bile and when administered for sufficiently long periods of time can induce dissolution of Ch gallstones. Equilibrium is approached very slowly in a detergent system, and thus the most important behavior in a model bile system dissolving solid ChM crystals is the dynamics of the solubilization process and in particular the dissolution rate. The presence of an interfacial barrier on the surface of Ch gallstones is an important discovery for the understanding of factors regulating dissolution rates[5,6,7].
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© 1985 Plenum Press, New York
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Salvioli, G. (1985). Dissolution of Cholesterol Gallstones in Bile. In: Galli, G., Bosisio, E. (eds) Liver, Nutrition, and Bile Acids. NATO ASI Series, vol 90. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9427-7_12
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DOI: https://doi.org/10.1007/978-1-4615-9427-7_12
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