Skip to main content

Hemostatic Parameters and Ischemic Heart Disease

  • Chapter
Advances in Hemostasis and Thrombosis

Part of the book series: Ettore Majorana International Science Series ((LIFESCI,volume 20))

  • 44 Accesses

Abstract

Ischemic heart disease (IHD) is caused by a discrepancy in oxygen supply and demand in the myocardium. Interest in platelet function studies in IHD patients has been stimulated for many years by the knowledge that coronary thrombosis often accompanies myocardial infarction (MI), and this has been increased by discoveries regarding both the platelets’ role in the pathogenesis of atherosclerosis and the biologic activity of platelet thromboxane A2 (TXB2) in the genesis of coronary angina and MI.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Hamberg, J. Svensson, and B. Samuelsson, Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides, Proc. Natl. Acad. Sci. USA, 72: 2294 (1975).

    Article  Google Scholar 

  2. W. Hope, T.J. Martin, C.N. Chesterman, and F.J. Morgan, Human β-thromboglobulin inhibits PGI2 production and binds to a specific site in bovine aortic endothelial cells, Nature, 282: 210 (1978).

    Article  ADS  Google Scholar 

  3. R.I. Handin and H.J. Cohen, Purification and binding properties of human platelet factor 4, J. Biol. Chem., 251: 4273 (1975).

    Google Scholar 

  4. L.D. Witte, K.L. Kaplan, H.L. Nossel, G.A. Lager, H.J. Weiss, and D.S. Goodman, Studies of the release from human platelets of the growth factor for cultured human arterial smooth muscle cells, Circ. Res., 42: 402 (1978).

    Article  Google Scholar 

  5. R. Ross, J. Glomset, B. Kariya, and L. Harker, A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vivo, Proc. Natl. Acad. Sci. USA, 71: 1207 (1974).

    Article  ADS  Google Scholar 

  6. Anturan Reinfarction Italian Study, Sulfinpyrazone in post-myocardial infarction, Lancet, 1: 237 (1982).

    Google Scholar 

  7. M. Cortellaro, C. Boschetti, G. Fassio, L. Baroni, and E.E. Polli, Haemostatic function changes in a trial on the secondary prevention of myocardial infarction with sulfinpyrazone, Acta Haematol., 65: 193 (1981).

    Article  Google Scholar 

  8. M. Cortellaro, C. Boschetti, P. Beggi, and E.E. Polli, In vivo platelet hyperactivity and factor VIII related antigen increase long after myocardial infarction, Scand. J. Haematol., 26: 106 (1981).

    Article  Google Scholar 

  9. C. Praga, M. Cortellaro, and E. Pogliani, Standardized bleeding time in the drugs interfering with platelet function, in: “Platelet Function in Thrombosis: A Review of Methods,” Plenum Press, New York, pp. 149–153 (1972).

    Chapter  Google Scholar 

  10. A.J. Hellem, Platelet adhesiveness in von Willebrand’s disease. A study with a new modification of the glass bead filter method, Scand. J. Haematol., 7: 374 (1970).

    Google Scholar 

  11. K. Harada and M.B. Zucker, Simultaneous development of platelet factor 4 activity and release of C-serotonin, Thromb. Diath. Haemorrh., 25: 41 (1971).

    Google Scholar 

  12. J.R. O’Brien, J.B. Heywood, and J.A. Heady, A quantitation of platelet aggregation induced by four compounds: a study in relation to myocardial infarction, Thromb. Diath. Haemorrh., 16: 752 (1966).

    Google Scholar 

  13. J.V.R. Born and M.J. Cross, The aggregation of blood platelets, J. Physiol., 168: 178 (1973).

    Google Scholar 

  14. M.B. Donati, G. De Gaetano, J. Vermylen, and M. Verstraete, II Fibrin Polymeration Time (FTP) test: un metodo rapido, semplice e sensibile per la determinazione della fibrino-genemia, Farmaco, 27: 214 (1972).

    Google Scholar 

  15. S. Villa, M. Livio, and G. De Gaetano, The inhibitory effect of aspirin on platelet and vascular prostaglandins in rats cannot be completely dissociated, Br. J. Haematol., 42: 425 (1979).

    Article  Google Scholar 

  16. M.J. Stuart, S. Murphy, and F.A. Oski, A simple non-radioisotope technic for the determination of platelet life-span, N. Engl. J. Med., 292: 1310 (1975).

    Article  Google Scholar 

  17. C. Laurell, Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies, Anal. Biochem., 15: 45 (1966).

    Article  Google Scholar 

  18. J.R. O’Brien, M.D. Etherington, S. Jamieson, P. Lawford, J. Sussex, and S.B. Lincoln, Heparin neutralizing activity test in the diagnosis of myocardial infarction, J. Clin. Pathol., 28: 975 (1975).

    Article  Google Scholar 

  19. P.P. Steele, H.S. Weiss, H. Davies, and E. Genton, Platelet function studies in coronary artery disease, Circulation, 48: 1194 (1973).

    Article  Google Scholar 

  20. J.A. Ritchie and L.A. Harker, Platelet and fibrinogen survival in coronary atherosclerosis. Response to medical and surgical therapy, Am. J. Cardiol., 39: 595 (1977).

    Article  Google Scholar 

  21. M. Cortellaro, C. Boschetti, G. Fassio, and E.E. Polli, A controlled study of the effect of sulfinpyrazone on platelet survival and on platelet bound C-serotonin release in patients with previous myocardial infarction, Acta Haematol., 61: 68 (1979).

    Article  Google Scholar 

  22. P. Han, A.G.G. Turpie, E. Genton, J. Hirsh, and M. Gent, Negative correlation between platelet survival, β-thrombo-globulin and platelet aggregate ratio in patients with coronary artery disease, Circulation, 58(Suppl. 11): 116 Abstr. (1978).

    Google Scholar 

  23. J.C. Giddings, L.R. Brookes, F. Piovella, and A.L. Bloom, Immunohistological comparison of platelet factor 4 (PF ), fibronectin (Fn), and factor VIII-related antigen (VIIIR:Ag) in human platelet granules, Br. J. Haematol., 52: 79 (1982).

    Article  Google Scholar 

  24. J.H. Rand, R.E. Gordon, I.I. Sussman, S.V. Chu, and V. Solomon, Electron microscopic localization of factor VIII-related antigen in adult human blood vessels, Blood, 60: 627 (1982).

    Google Scholar 

  25. L.A. Harker, R.J. Wall, and J.M. Harlen, Sulfinpyrazone prevention of homocystein-induced endothelial cell injury and arteriosclerosis, Clin. Res., 26: 554 (1978).

    Google Scholar 

  26. A.B. Nichols, J. Owen, K.L. Kaplan, R.R. Sciacca, P.J. Cannon, and H.L. Nossel, Fibrinopeptide A, platelet factor 4, and Ăź-thromboglobulin levels in coronary heart disease, Blood, 60: 650 (1982).

    Google Scholar 

  27. K.L. Kaplan, H.L. Nossel, M. Drillings, and G. Lasznik, Radioimmunoassay of platelet factor 4 and Ăź-thromboglobulin: development and application to studies of platelet release reaction to fibrinopeptide A generation, Br. J. Haematol., 39: 129 (1978).

    Article  Google Scholar 

  28. H.L. Nossel, M. Ti, K.L. Kaplan, K. Spanondis, T. Soland, and Y.P. Butler, The generation of fibrinopeptide A in clinical blood samples. Evidence for thrombin activity, J. Clin. Invest., 58: 1136 (1976).

    Article  Google Scholar 

  29. S.P. Levine, J.A. Lindenfeld, J.B. Ellis, N.M. Raymond, and L.S. Krentz, Increased plasma concentrations of platelet factor 4 in coronary artery disease, Circulation, 64: 626 (1981).

    Article  Google Scholar 

  30. G.C. White and A.A. Marony, Platelet factor 4 levels in coronary artery disease, J. Lab. Clin. Med., 97: 369 (1981).

    Google Scholar 

  31. M. Sobel, E.W. Salzman, G.C. Davies, R.I. Handin, J. Sweeney, J. Ploetz, and G. Kurland, Circulating platelet products in unstable angina pectoris, Circulation, 63: 300 (1981).

    Article  Google Scholar 

  32. G.G. Neri Serneri, G.F. Gensini, R. Abbate, C. Mugnaini, G. Favilla, C. Brunelli, S. Chierchia, and O. Parodi, Increased fibrinopeptide A formation and thromboxane A2 production in patients with ischemic heart disease: relationships to coronary pathoanatomy, risk factors, and clinical manifestations, Am. Heart J., 101: 185 (1981).

    Article  Google Scholar 

  33. L.H. Green, E. Seroppian, and R.I. Handin, Platelet activation during exercise-induced myocardial ischemia, N. Engl. J. Med., 302: 193 (1980).

    Article  Google Scholar 

  34. J.R. Stratton, T.W. Malpass, J.L. Ritchie, M.A. Pfeifer, and L.A. Harker, Studies of platelet factor 4 and beta-thromboglobulin release during exercise: lack of relationship to myocardial ischemia, Circulation, 66: 33 (1982).

    Article  Google Scholar 

  35. J. Mehta, P. Mehta, C.J. Pepine, and C.R. Conti, Platelet function studies in coronary artery disease. VII: Effect of aspirin and tachycardia stress on aortic and coronary venous blood, Am. J. Cardiol., 45: 945 (1980).

    Article  Google Scholar 

  36. J.T. Dalai, D.J. Sheridan, A.L. Bloom, and A.H. Henderson, Platelet aggregates and coronary spasm, Lancet, ii: 1146 (1980).

    Article  Google Scholar 

  37. S. Simonsen, J. Dali, T. Hovig, J. Kjeskus, N.V. Solmon, and E. Thanlow, Myocardial ischemia and platelet reactivity, in: VIII European Congress of Cardiology, Abstr. 126, Paris (1980).

    Google Scholar 

  38. R.M. Robertson, D. Robertson, L.J. Roberts, R.L. Maas, G.A. Fitzgerald, G.C. Friesinger, and J.A. Oates, Thromboxane A2 in vasotonic angina pectoris, N. Engl. J. Med., 304: 998 (1981).

    Article  Google Scholar 

  39. R.I. Lewy, L. Wiener, P. Walinsky, A.M. Lefer, M.J. Silver, and J.B. Smith, Thromboxane A2 in Prinzmetal’s variant angina and classical angina pectoris, Clin. Cardiol., 2: 404 (1979).

    Article  Google Scholar 

  40. R.I. Lewy, L. Wiener, P. Walinsky, A.L. Lefer, M.J. Silver, and J.B. Smith, Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature, Circulation, 61: 1165 (1980).

    Article  Google Scholar 

  41. M. Tada, T. Kuruya, M. Imane, K. Kadama, M. Mishima, M. Yamada, M. Inui, and H. Abe, Elevation of thromboxane B2 levels in patients with classic and variant angina pectoris, Circulation, 64: 1107 (1981).

    Article  Google Scholar 

  42. M. Sobel, E.W. Salzman, G.C. Davies, R.I. Handin, J. Sweeney, J. Ploetz, and G. Kurland, Circulating platelet products in unstable angina pectoris, Circulation, 63: 300 (1981).

    Article  Google Scholar 

  43. P.D. Hirsh, L.D. Hillis, W.B. Campbell, B.G. Firth, and J.T. Willerson, Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease, N. Engl. J. Med., 304: 685 (1981).

    Article  Google Scholar 

  44. R.I. Lewy, Thromboxane in ischemic heart disease, N. Engl. J. Med., 305: 186 (1981).

    Google Scholar 

  45. S. Chierchia, C. Patrono, F. Créa, G. Ciabattoni, R. De Caterina, G.A. Cinotti, A. Distante, and A. Maseri, Effects of intravenous prostacyclin in variant angina, Circulation, 65: 470 (1982).

    Article  Google Scholar 

  46. S. Chierchia, R. De Caterina, F. Créa, C. Patrono, and A. Maseri, Failure of thromboxane A blockade to prevent attacks of vasospastic angina, Circulation, 66: 702 (1982).

    Article  Google Scholar 

  47. R.M. Robertson, D. Robertson, L.J. Roberts, R.L. Mass, G.A. Fitzgerald, G.C. Friesinger, and J.A. Oates, Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitory trials, N. Engl. J. Med., 304: 988 (1981).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Cortellaro, M., Boschetti, C., Moreo, G., Antoniazzi, V. (1985). Hemostatic Parameters and Ischemic Heart Disease. In: Cajozzo, A., Perricone, R., Di Marco, P., Palazzolo, P. (eds) Advances in Hemostasis and Thrombosis. Ettore Majorana International Science Series, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9424-6_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9424-6_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9426-0

  • Online ISBN: 978-1-4615-9424-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics