Abstract
Reptiles and amphibians have been reported to harbor and maintain susceptibility to a wide range of potentially pathogenic agents (Ahne, 1977; Anver et al., 1976; Brock et al., 1976; Cooper et al., 1978; Cosgrove and Jared, 1974; Dondaldson et al., 1975; Glorioso et al., 1974; Kwapinski et al., 1974; Marcus, 1971; McKenzie and Green, 1976; Mizeli, 1968; Page, 1966; Reichenbach-Klinke and Elkan, 1965; Scherr and Rippon, 1959; Telford, 1971; Vogel, 1958). Antigenic components from bacterial and viral agents have been shown to stimulate agglutinating and neutralizing antibody production in lower vertebrates, including all orders of reptiles and some amphibians (Good and Papermaster, 1964). Cell-mediated immune responses to such agents in these species have only recently been investigated.
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References
Ahne, W., 1977, Review of viruses of Poikilothermic vertebrates, Tier Praxis, 5:529–540.
Allen, F.W., and McDaniel, E.C., 1937, A study of the relation of temperature to antibody formation in cold-blooded animals, J. Immunol., 32:143–152.
Ambrosius, H., Hemmerling, J., Richter, R., and Schimke, R., 1970, Immunoglobulins and the dynamics of antibody formation in Poikilothermic vertebrates (pisces, urodela, reptilia), in: “Developmental aspects of antibody formation and structure,” J. Sterzl and I. Riha, eds., Academic Press, New York.
Anver, M.R., Parks, J.S., and Rush, H.G., 1976, Dermato-philosis in the marble lizard (Calotes mystaceus), Lab. Animal Sci., 26:817–823.
Atwell, J.L., and Marchalonis, J.J., 1976, Immunoglobulin class of lower vertebrates distinct from IgM immunoglobulin, in: “Comparative immunology,” J.J. Marchalonis, ed., Blackwell, Oxford.
Avtalion, R.R., Weiss, E., and Moalem, T., 1976, Regulatory effects of temperature upon immunity in ecto-thermic vertebrates, in: “Comparative immunology,” J.J. Marchalonis, ed., Blackwell, Oxford.
Avtalion, R.R., Wojdani, A., Malik, Z., Shahrabani, R., and Duczyminer, M., 1973, Influence of environmental temperature on the immune response in fish, Current Topics Microbiol. Immunol., 61:1–36.
Ballow, M., 1977, Phylogenetics and ontogenetics of the complement systems, in: “Comprehensive immunology, Vol. II, Biological amplification systems in immunology,” Plenum Publ. Corp., New York.
Balls, R., and Ruben, L.N., 1976, Phylogeny of neoplasia and immune reactions to tumors, in: “Comparative immunology,” J.J. Marchalonis, ed., Blackwell, Oxford.
Baril, E., Palmer, J., and Bartel, H.H., 1961, Electrophoretic analysis of young alligator serum, Science, 133:278–279.
Benedict, A.A., and Pollard, L.W., 1972, Three classes of immunoglobulins found in the sea turtles, Chelonia mydas, Folia Microbiol., 17:75–78.
Bisset, K.A., 1947, Bacterial infection and immunity in lower vertebrates and invertebrates, J. Hyg., 45:128–134.
Bisset, K.A., 1948, The effect of temperature upon antibody production in cold-blooded vertebrates, J. Pathol. Bacterid., 60:87–92.
Bond, R.G., 1939, Serological studies of the Reptilia. I. Hemagglutinins and hemagglutinogens of snake blood, J. Immunol., 36:1–9.
Bond, R.G., and Sherwood, N.P., 1939, Serological studies of the Reptilia. II. The hemolytic property of snake serum, J. Immunol., 36:11–16.
Borysenko, M., 1969a, Skin allograft and xenograft rejection in the snapping turtle, Chelydra serpentina, J. Exp. Zool., 170:341–358.
Borysenko, M., 1969b, The maturation of the capacity to reject skin allografts and xenografts in the snapping turtle, Chelydra serpentina, J. Exp. J. Exp. Zool., 170:359–364.
Borysenko, M., 1970, Transplantation immunity in Reptilia, Transplant Proc, 2:299–306.
Borysenko, M., 1976, Changes in spleen history in response to antigenic stimulation in the snapping turtle, Chelydra serpentina, J. Morphol., 149:223–241.
Borysenko, M., and Cooper, E.L., 1972, Lymphoid tissue in the snapping turtle, Chelydra serpentina, J. Morphol., 138:487.
Brock, J.A., Nakamura, R.M., and Miyahara, A.Y., 1976, Tuberculosis in pacific green turtles, Chelonia mydas, Trans. Amer. Fish Soc, 105:564–566.
Campbell, P.A., 1976, Immunocompetent cells in resistance to bacterial infections, Bacteriol. Rev., 40: 284–313.
Charon, N.W., Johnson, R.C., and Muschel, L.H., 1975, Antileptospiral activity in lower-vertebrate sera, Infect. Immun., 12:1386–1391.
Ching, Y.C., and Wedgwood, R.J., 1967, Immunologic response in the axolotl, Siredon mexicanum, J. Immunol., 99:191–200.
Clothier, R.H., and Balls, M., 1973, Mycobacteria and lymphoreticular tumors in Xenopus laevis, the South African clawed toad. I. Isolation, characterization and pathogenicity for Xenopus, Oncology, 28:445–457.
Coe, J.E., 1972, Immune response in the turtle, Chrysemys picta, Immunology, 23:45–52.
Coe, J.E., Leong, D., Portis, J.L., and Thomas, L.A., 1976, Immune response in the garter snake, Immunology, 31:417–424.
Cohen, N., 1971, Reptiles as models for the study of immunity and its phylogenesis, J. Amer, Vet. Med. Ass., 159:1662–1671.
Cohen, S.G., Sapp, T.M., and Shaskas, J.R., 1971, Phylo-geny of hypersensitivity. I. Anaphylactic responsiveness of the frog, Rana pipiens, J. Allergy, 47:121–130.
Cooper, E.L., 1968, Chronic allograft rejection in the iguana, Ctenosaura pectinata, Proc. Soc. Exp. Biol. Med., 128:150–154.
Cooper, E.L., 1969, Skin transplant rejection in apodan amphibians and lacertilian reptiles, Amer. Zool., 9:333–337.
Cooper, E.L., 1976, The immunoglobulins in.: “Comparative immunology,” J.J. Marchalonis, ed., Blackwell, Oxford.
Cooper, J.E., Needham, J.R., and Griffin, J., 1978, A bacterial disease of Darwin’s frog (Rhinoderma darwini), Lab. Animal, 12:91–93.
Cosgrove, G. E., and Jared, D.W., 1974, Diseases and parasites of Xenopus, the clawed toad, in: “roceedings of the Gulf Coast regional symposium on diseases of aquatic animals,” R.L. Amborski, M.A. Hood, and R.R. Miller, eds., Louisiana State Univ. Press, Baton Rouge.
Day, N.K.B., Gewurz, H., Johannsen, R., Finstad, J., and Good, R.A., 1970a, Complement and complementlike activity in lower vertebrates and invertebrates, J. Exp. Med., 132:941–950.
Day, N.K.B., Good, R.A., Finstad, J., Johannsen, R., and Pickering, R.J., 1970b, Interactions between endotoxic lipopolysaccharides and the complement system in the sera of lower vertebrates, Proc. Soc. Exp. Biol. Med., 133:1397–1401.
Dessauer, H., 1974, Plasma proteins of Reptilia, in; “Chemical zoology section II-Reptilia,” M. Florkin and B.T. Scheer, eds., Academic Press, New York.
Donaldson, M., Heyman, D., Dempster, R., and Garcia, L., 1975, Epizootics of fatal amebiasis among exhibited snakes: Epidemiologic, pathologic and chemotherapeutic considerations, Amer. J. Vet. Res., 36:807–817.
Downs, C.M., 1928, Anaphylaxis. Vii. Active anaphylaxis in turtles, J. Immunol., 15:77–81.
Droessler, K., and Ambrosius, H., 1972, Specific cell-mediated immunity in batrachians: I. Delayed hypersensitivity to B.C.G. in the toad (Bufo bufo), ACTA Biol. Med. Germ., 29:441–445.
Drutz, D., 1976, Immunity and infection, in: “Basic and clinical immunology,” H.H. Fudenberg, D.P. Stites, J.L. Caldwell, and V. Wells, eds., Lange Medical Publ., Los Altos.
Dujarric De la Riviiere, R., Eyquem, A., and Fine, J., 1974, Les hemagglutinines et hemagglutinogens du sange de Vipera aspis, Experimentia, 10:159–165.
DuPasquier, L., and Weiss, N., 1973, The thymus during the ontogeny of the toad, Xenopus laevis: Growth, membrane-bound immunoglobulins and mixed lymphocyte reaction, European J. Immunol., 3:773–777.
Evans, E.E., 1963a, Antibody response in amphibia and reptiles, Proc. Soc. Exp. Biol., 22:1132–1137.
Evans, E.E., 1963b, Comparative immunology antibody response in Dipsosaurus dorsalis at different temperatures, Proc. Soc. Exp. Biol. Med., 112: 531–533.
Evans, E.E., Kent, S.P., Attkeberger, M., Seibert, C., Bryant, R.E., and Booth, B., 1965, Antibody synthesis in Poikilothermic vertebrates, Ann. New York Acad. Sci., 126:629–646.
Everly, M.E., and Hanson, R.J., 1965, Bacterial (staphylococci) phagocytosis in the dorsal lymph sac of Rana pipiens, Proc. Indiana Acad. Sci., 75: 56–60.
Fenner, F., McAuslan, B.R., Mims, C.A., Sambrook, J., and White, D.O., 1974, “The biology of animal viruses,” 2nd ed., Academic Press, New York.
Ferris, D.H., 1961, Research into the nidality of Leptospira ballum in campestral hosts, including the hog-nosed snake, Heterodon platyrhincos, Cornell Vet., 51:405–419.
Flexner, S., and Noguchi, H., 1901, Snake venom in relation to hemolysis, bacteriolysis and toxicity, J. Exp. Med., 6:277–301.
Fudenberg, H.H., Stites, D.P., Caldwell, J.L., and Wells, V., 1976, The complement systems, in: “Basic and clinical immunology,” H.H. Fundenberg, D.P. Stites, J.L. Caldwell and V. Wells, eds., Lange Medical Publ., Los Altos.
Gebhardt, L.P., St. Jeor, S.C., Stanton, G.J., and Stringfellow, D.A., 1973, Ecology of western encephalitis virus, Proc. Soc. Exp. Biol. Med., 142:731–733.
Glorioso, J.C., Amborski, R.L., Amborski, G.F., and Culley, D.D., 1974, Microbiological studies on septicemic bullfrogs (Rana catesbeiana), Amer. J. Vet. Res., 35:447–450.
Good, R.A., and Papermaster, B.W., 1964, Ontogeny and phylogeny of adaptive immunity, Adv. Immunol., 4:1–115.
Good, R.A., Finstad, J., Pollara, B., and Gabrielason, A.E., 1966, “Phylogeny of immunity,” Univ. Florida Press, Gainsville.
Grasset, E., Zoutendyk, A., and Schoafsma, A., 1935, Sur la production d-agglutinines antibacteriennes chez les reptiles, Compt. Rend. Soc. Biol., 119:67–70.
Green, N., and Cohen, N., 1977, Effect of temperature on serum complement levels in the leopard frog, Rana pipiens, Develop. Comp. Immunol., 1:59–64.
Gresikova Kohutova, M., and Albect, P., 1959, Experimental pathogenicity of the tick-borne encephalitis virus for the green lizard, Lacerta viridis, J. Hyg. Epidemiol. Microbiol. Immunol., 3:258–263.
Grey, H.M., 1963, Phylogeny of the immune responses. Studies on some physical, chemical and serologic characteristics of antibody produced in the turtle, J. Immunol., 91:819–825.
Hemmerling, J., 1970, Soluble antigen-antibody complexes: Studies on Ophisaurus apodus (Reptilia, Lacertilia, Anguidae), Allerg. Immunol., 17:154–160.
Hemmerling, J., and Ambrosius, H., 1971, Contributing to the immunobiology of Poikilothermic vertebrates. VII. Immunoglobulins and antibody formation by scheltopusik, Ophisaurus apodus (Reptilia, Lacertilia, Anguidae), ACTA Biol. Med. Germ., 27:783–793.
Horton, J.D., 1969, Ontogeny of the immune response to skin allografts in relation to lymphoid organ development in the amphibian, Xenopus laevis Daudin, J. Exp. Zool., 170:449–466.
Horton, J. D., 1980, “Development and differentiation of vertebrate lymphocytes,” Elseiver/North-Holland Biomedical Press, New York.
Houdayer, M., and Fougereau, M., 1972, Phylogenie des immunogloulines: La reaction immunitaire de l’axolotl, Ambystoma mexicanum, cinetique de la response immunitaire et caracterisation des anticorps, Ann. L’Inst. Pasteur, 12 3:3–28.
Hussein, M.F., Badir, N., El Ridi, R., and Akef, M., 1978a, Differential effect of seasonal variation on lymphoid tissue of the lizard, Chalcides ocellatus, Develop. Comp. Immunol., 2:297–310.
Hussein, M.F., Badir, N., El Ridi, R., and Akef, M., 1978b, Effect of seasonal variation on lymphoid tissues of the lizards, Mabuya quinquetaeniata Light and Uromastyx aegyptia Forsk, Develop. Comp. Immunol., 2:469–478.
Hussein, M.F., Badir, N., El Ridi, R., and Akef, M., 1979a, Lymphoid tissues of the snake, Spaleroso-phis diadema, in the different seasons, Develop. Comp. Immunol., 3:77–88.
Hussein, M.F., Badir, N., El Ridi, R., and El Deeb, S., 1979b, Effect of seasonal variation on immune system of the lizard, Scincus scincus, J. Exp. Zool., 209:91–96.
Jayarman, S., and Muthukkaruppan, V.R., 1978, Detection of cell-mediated immunity of sheep erythrocytes by the capillary migration inhibition technique in the lizard, Calotes versicolor, Immunology, 34:231–240.
Jurd, R.D., 1977, Secretory immunoglobulins and gut-associated lymphoid tissue in Xenopus laevis, in: “Developmental immunobiology,” J.B. Solomon and J.R. Horton, eds., Elseiver/North-Holland Biomedical Press, New York.
Kaminski, S., and Karzon, D.T., 1969, Comparative immune response to amphibian cytoplasmic viruses assayed by the complement fixation and gel immunodiffusion tests, J. Immunol., 103:260–267.
Kanakambika, P., and Muthukkaruppan, V., 1972, Immunological competence in the newly hatched lizard, Calotes versicolor, Proc. Soc. Exp. Biol. Med., 140:21–23.
Karstad, L., 1961, Reptiles as possible reservoir hosts for eastern encephalitis virus, Trans. North Amer. Wildlife Natur. Res. Conf., 26:186–202.
Karstad, L., 1963, Influence of low body temperatures on establishment of prolonged infections in animal reservoirs, Sci. Proc. 100th Ann. Meeting Amer. Vet. Med. Ass., New York.
Kendall, S., and Minton, S.A., 1969, Serum profiles of certain reptile sera and preliminary observations on antibody formation in snakes, Proc. Indiana Acad. Sci., 78:113–114.
Kendall, S., and Minton, S.A., 1973, Immune responses of snakes, Copeia, 1973:504–515.
Kent, R., 1966, Uptake of carbon particles by the RES of the fowl, the frog, and the chick embryo, J. Reticuloendothelial Soc, 3:271–293.
Kidder, G.M., Ruben, L.N., and Stevens, J., 1973, Cyto-dynamics and ontogeny of the immune response of Xenopus laevis against sheep erythrocytes, J. Embryol. Exp. Morphol., 29:73–85.
Kubo, R.T., Zimmerman, B., and Grey, H.M., 1973, Phylogeny of immunoglobulins, in: “The antigens,” Vol.1, M. Sela, ed., Academic Press, New York.
Kulp, W.L., and Borden, D.G., 1942, Further studies on Proteus hydrophilus, the etiological agent in “red-leg” disease of frogs, J. Bacterid., 44: 673–685.
Kwapinski, J.B.G., Kwapinski, E.H., and McClurg, N.M., 1974, The growth of Mycobacterium leprae in snakes, Canadian J. Microbiol., 20:420–422.
Legier, D.W., Evans, E.E., Weinheimer, P.F., Acton, R.T., and Attleberger, M.H., 1969, Immunoglobulin and complement systems of amphibian serum, in: “Biology of amphibian tumors,” M. Mizeli, ed., Springer-Verlag, New York.
Lerch, E.G., Huggins, S.E., and Bartel, A.H., 1967, Comparative immunology. Active immunization of young alligators with hemocyanin, Proc. Soc. Exp. Biol. Med., 124:448–451.
Leslie, G.A., and Clem, L.W., 1972, Phylogeny of immunoglobulin structure and function. VI. 175, 755 anti-DNP of the turtle, Pseudemys scripta, J. Immunol., 108:1656–1664
Lin, H.H., Caywood, B.E., and Rowlands, R.T., Jr., 1971, Primary and secondary immune responses of the marine toad (Bufo marinus) to bacteriophage f2, Immunology, 20:373–380.
Lykakis, J.J., 1969, The production of two molecular classes of antibody in the toad, Xenopus laevis, homologous with mammalian IgM (19S) and IgG (7S) immunoglobulins, Immunology, 16:91–98.
Manickavel, V., and Muthukkaruppan, V.R., 1969, Allograft rejection in the lizard, Calotes versicolor, Transplantation, 8:307–310.
Marchalonis, J.J., 1971, Immunoglobulins and antibody production in amphibians, Amer. Zool., 11:171–181.
Marchalonis, J.J., and Cohen, N., 1973, Isolation and partial characterization of immunoglobulin from a urodele amphibian (Necturus maculosus), Immunology, 24:395–407.
Marchalonis, J.J., and Edelman, G.M., 1966, Phylogenetic origins of antibody structure. II. Immunoglobulins of the primary response of the bullfrog, Rana catesbeiana, J. Exp. Med., 124:901–913.
Marchalonis, J.J., and Germain, R.N., 1980, Antibody memory, and tolerance in the marine toad (Bufo marinus), in: “Phylogeny of immunological memory,” M.J. Manning, ed., Elsevier/North Holland Biomedical Press, New York.
Marchalonis, J.J., Ealey, E.H.M., and Diener, E., 1969, Immune response of the tuatara, Sphenodon punctatum, Australian J. Exp. Biol. Med. Sci., 47:367–380.
Marcus, L.C., 1971, Infectious diseases of reptiles, J. Amer. Vet. Med. Ass., 159:1626–1631.
Maslin, T.P., 1967, Skin grafting in the bisexual teiid lizard, Cemidophorus sexlineatus and in the unisexual C. tesselatus, J. Exp. Zool., 166:137–150.
Maung, R.T., 1963, Immunity in the tortoise, Testudo iberla, J. Pathol. Bacterid., 85:51–66.
McKenzie, R.A., and Green, P.E., 1976, Mycotic dermatitis in captive carpet snakes, J. Wildlife Dis., 12:405–408.
Metchnikoff, E., 1893, “Lectures on the comparative pathology of inflammation,” Dover, New York. (1968 republication of 1893 edition)
Mizeli, M., 1968, “Recent results in cancer research: Biology of amphibian tumors,” Springer-Verlag, New York.
Page, L.A., 1966, Diseases and infections of snakes: A review, Bull. Wildlife Dis. Ass., 2:111–126.
Pavlov, P., Dimov, D., Tchilev, D., and Janvev, J., 1961, Tularemia antibodies in tortoises in Bulgaria, Ann. Inst. Pasteur, 100:261–263.
Pillai, P., and Muthukkaruppan, V., 1977, The kinetics of rosette-forming cell responses against sheep erythrocytes in the lizard, J. Exp. Zool., 199: 97–104.
Portis J., and Coe, J.E., 1975, IgM, the secretory immunoglobulin of reptiles and amphibians, Nature, 258:547–548.
Rosenquist, G.L., and Hoffman, R.Z., 1972, The production of anti-DNP antibody in the bullfrog, Rana catesbeiana, J. Immunol., 108:1499–1505.
Reichenbach-Klinke, H., and Elkan, E., 1965, “The principal diseases of lower vertebrates,” Academic Press, New York.
Salintino, S.K., and Minton, S.A., Jr., 1973, Immunological response of snakes, Copeia, 1973:504–515.
Saluk, P.H., Krauss, J., and Clem, L.W., 1970, The presence of two antigenically distinct light chains in alligator immunoglobulins, Proc. Soc. Exp. Biol. Med., 133:365–369.
Scherr, G.H., and Rippon, P.R., 1959, Experimental histoplasmosis in cold-blooded animals, Mycopathol. Mycol. Appl., 11:241–249.
Schwab, G.E., and Reeves, P.R., 1966, Comparison of the bacteriocidal activity of different vertebrate sera, J.Bacteriol., 91:106–112.
Tait, N.N., 1969, Immune response of the lizard, Egernia cunninghami, Physiol. Zool., 42:29–35.
Telford, S.R., 1971, Parasitic diseases of reptiles, J. Amer. Vet. Med. Ass., 159:1644–1652.
Thomas, L.A., and Eklund, C.M., 1962, Overwintering of western equine encephalomyelitis virus in garter snakes experimentally infected by Culex tarsalis, Proc. Soc. Exp. Biol. Med., 109:421–424.
Timourian, H., Dobson, C.J., and Sprent, J.F.A., 1961 Precipitating antibodies in the carpet snake against parasitic nematodes, Nature, 192:996–997.
Tournefier, A., and Charlemangne, J., 1975, Antibodies against Salmonella and SRBC in urodele amphibians: Synthesis and characterization, in: “Immunologic phylogeny,” W.H. Hildemann and A.A. Benedict, eds., Plenum Publ. Corp., New York.
Turner, R.J., 1979, Antimicrobial responses in amphibia, J. Royal Soc. Med., 72:697–701.
Vogel, H., 1958, Mycobacteria for cold-blooded animals, Amer. Rev. Tuberc. Pulmonary Dis., 77:823–838.
Wetherall, J.D., and Turner, K.J., 1972, Immune response in the lizard, Australian J. Exp. Biol. Med. Sci., 50:79–95.
White, F.H., 1963, Leptospiral agglutinins in snake serums, Amer. J. Vet. Res., 24:179–182.
Wright, R., and Cooper, E.L., 1980, Temperature and immunological memory in anuran amphibians, in: “Phylogeny of immunological memory,” M.J. Manning, ed., Elsevier/North Holland Biomedical Press, New York.
Wright, R., and Schapiro, H., 1973, Primary and secondary immune responses of the desert iguana, Diposo-saurus dorsalis, Herpetologica, 29:275–280.
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Kollias, G.V. (1984). Immunologic Aspects of Infectious Diseases. In: Hoff, G.L., Frye, F.L., Jacobson, E.R. (eds) Diseases of Amphibians and Reptiles. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9391-1_26
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