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Mechanisms of Mediator Release from Neutrophils

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Eukaryotic Cell Cultures

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 172))

Abstract

The encounter of neutrophils with immune complexes and complement components — in the bulk phase or on a surface — leads to their secretion of lysosomal hydrolases, especially neutral proteases, which provoke tissue injury. Secretion of lysosomal enzymes and generation of reactive oxygen species (e.g., O2 p2212; generation are stimulus-specific and can be dissected to establish cause and effect relationships by means of: a) kinetic analysis, b) variations in the stimulus, and c) use of impermeant reagents to block discrete responses. Neutrophils also generate products of 11-cyclooxygenase (e.g., PGE2, TxA2) and of the 5- and 15-lipoxygenases (mono-, di-, and tri-HETEs, LTB4, and their isomers). But the cyclooxygenase products (save TxA2) are not phlogistic by themselves: they inhibit the functions of neutrophils, platelets, macrophages, and mast cells. The most potent pro-inflammatory agent yet identified as a product of arachidonate is LTB4. LTB4 is a potent Ca ionophore, constricts airways, is a potent chemoattractant, and induces local inflammation.

Recipient of Predoctoral Fellowship CAO-9161, Department of Pathology, New York University School of Medicine

Fellows of the Arthritis Foundation

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References

  1. D.G. Palmer, Total leukocyte enumeration in pathologic synovial fluids. Am. J. Clin. Path. 49:812–818, 1968.

    Google Scholar 

  2. J.R. Winchester, H.J. Kunkel and V. Agnello, Occurrence of gamma globulin complexes in serum and joint fluid of rheumatoid arthritis patients: use of monoclonal rheumatoid factors as reagents for their demonstration. J. Exp. Med. 134:286s–293s, 1971.

    Google Scholar 

  3. N.J. Zvaifler, Breakdown products of C’3 in human synovial fluids. J. Clin. Invest. 48:1532–1539, 1969.

    Google Scholar 

  4. P.A. Ward and N.J. Zvaifler, Complement-derived leukotactic factors in inflammatory synovial fluids of humans. J. Clin. Invest. 50:606–612, 1971.

    Google Scholar 

  5. A. Cats, G.J.M. Lafeber and F. Klein, Immunoglobulin phagocytosis by granulocytes from sera and synovial fluids in various rheumatoid and non-rheumatoid diseases. Ann. Rheum. Dis. 40:55–59, 1975.

    Google Scholar 

  6. E.R. Hurd, J. LoSpalluto and M. Ziff, Formation of leukocyte inclusions in normal polymorphonuclear cells incubated with synovial fluid. Arth. and Rhuem. 13:724–733, 1970.

    Google Scholar 

  7. G. Weissmann, Lysosomes and joint disease. Arth. and Rheum. 9:834–840, 1966.

    Google Scholar 

  8. N.J. Zvaifler, Further speculation on the pathogenesis of joint inflammation in rheumatoid arthritis. Arth. and Rheum. 13:895–901, 1970.

    Google Scholar 

  9. A. Oronsky, L. Ignarro and R. Perper, Release of cartilage mucopolysaccharide-degrading neutral protease from human leukocytes. J. Exp. Med. 138:461–472, 1973.

    Google Scholar 

  10. N.M. Hadler, M.A. Johnson, J.K. Spitznagel and R.J. Quinet, Protease inhibitors in inflammatory synovial effusions. Ann. Rheum. Dis. 40:55–59, 1981.

    Google Scholar 

  11. H. Keiser, R.A. Greenwald, G. Feinstein and A. Janoff, Degradation of cartilage proteoglycans by human leukocyte granule neutral protease — a model of joint injury. II. Degradation of isolated bovine nasal cartilage proteoglycan. J. Clin. Invest. 57:625–637, 1976.

    Google Scholar 

  12. O. Ohno and T.D. Cooke, Electron microscopic morphology of immunoglobulin aggregates and their interactions in rheumatoid articular collagenous tissues. Arth. and Rheum. 21:516–527, 1978.

    Google Scholar 

  13. S. Shiozawa, H.E. Jasin and M. Ziff, Absence of immunoglobulins in rheumatoid cartilage-pannus junctions. Arth. and Rheum. 23:816-821.

    Google Scholar 

  14. P.M. Henson, The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles. J. Immunol. 107:1535–1546, 1971.

    Google Scholar 

  15. R.B. Zurier, S. Hoffstein and G. Weissmann, Mechanisms of lysosomal enzyme release from leucocytes. I. Effect of cyclic nucleotides and colchicine. J. Cell Biol. 58:27–41, 1973.

    Google Scholar 

  16. P.M. Henson, J.R. Hollister, R.A. Musson, R.O. Webster, P. Spears, J.E. Henson and K.M. McCarthy, Inflammation as a surface phenomenon: initiation of inflammatory processes by surface-bound immunologic compounds. In: Advances in Inflammation Research (Weissmann, G., Samuelsson, B. and Paoletti, R., eds.) 1:341–352, 1979.

    Google Scholar 

  17. H. Menninger, R. Putzier, W. Mohr, D. Wessinghage and K. Tillman, Granulocyte elastase at the site of cartilage erosion by rheumatoid synovial tissue. Z. Rheumatol. 39:145–156, 1980.

    Google Scholar 

  18. W. Mohr, H. Westerhellweg and D. Wessinhage, Polymorphonuclear granulocytes in rheumatic tissue destruction. III. An electron microscopic study of PMNs at the pannus-cartilage junction in rheumatoid arthritis. Ann. Rheum. Dis. 40:396–399, 1981.

    Google Scholar 

  19. W. Mohr, A. Wild and H.P. Wolf, Role of polymorphs in inflammatory cartilage destruction in adjuvant arthritis of rats. Ann. Rheum. Dis. 40:171–176, 1981.

    Google Scholar 

  20. S.M. Krane, Collagenase production by human synovial tissue. Ann. N.Y. Acad. Sci. 256:289–303, 1975.

    Google Scholar 

  21. J. Saklatvala and A.J. Barrett, Identification of proteinases in rheumatoid synovium: detection of leukocyte elastase cathepsin G and another serine proteinase. Biochim. Biophys. Acta 615:167–177, 1980.

    Google Scholar 

  22. C. May, B.B. Levine and G. Weissmann, Compounds inhibiting glucose utilization, antigenic release of histamine and phagocytic release of lysosomal enzyme from leucocytes of humans. Proc. Soc. Exp. Biol. & Med. 133:758–763, 1970.

    Google Scholar 

  23. G. Weissmann, R.B. Zurier, P.J. Spieler and I.M. Goldstein, Mechanisms of lysosomal enzyme release from leucocytes exposed to immune complexes and other particles. J. Exp. Med. 134:149s–165s, 1971.

    Google Scholar 

  24. E.L. Becker, Some interrelations of neutrophil chemotaxis, lysosomal enzyme secretion and phagocytosis, as revealed by synthetic peptides. Amer. J. Path. 85:385–394, 1976.

    Google Scholar 

  25. D.G. Wright, D.A. Bralove and J.I. Gallin, The differential mobilization of human neutrophil granules. Am. J. Pathol. 87:273–284, 1977.

    Google Scholar 

  26. G. Weissmann, Release of mediators of inflammation from stimulated neutrophils. N. Engl. J. Med. (Medical Seminars of the Beth Israel Hospital) 303:27–34, 1980.

    Google Scholar 

  27. J.E. Smolen and G. Weissmann, The secretion of lysosomal enzymes from human neutrophils: the first events in stimulus-secretion coupling. In: Lysosomes and Lysosomal Storage Diseases (Callahan, J.W. and Alexander-Lowden, J., eds.) Raven Press, New York, p. 31–62, 1981.

    Google Scholar 

  28. L.E. Hokin and M.R. Hokin, Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices. Biochim. Biophys. Acta 18:102–110, 1955.

    Google Scholar 

  29. J.W. Putney, Stimulus-permeability coupling: role of calcium in the receptor regulation of membrane permeability. Pharm. Rev. 30:209–245, 1979.

    Google Scholar 

  30. L.M. Lichtenstein and R. DeBernardo, IgE mediated histamine release: in vitro separation into two phases. Int. Arch. Allergy Appl. Immunol. 41:56–71, 1971.

    Google Scholar 

  31. P.J. Edelson, Monocytes and macrophages: aspects of their cell biology. In: Cell Biology of Inflammation (Weissmann, G., ed.) Elsevier North Holland Press, Amsterdam and New York, pp. 470–495, 1980.

    Google Scholar 

  32. I.M. Goldstein, D. Roos, G. Weissmann and H. Kaplan, Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis. J. Clin. Invest. 56:1155–1163, 1975.

    Google Scholar 

  33. I. Goldstein, S. Hoffstein, J. Gallin and G. Weissmann, Mechanisms of lysosomal enzyme release from human leukocytes: microtubule assembly and membrane fusion induced by a component of complement. Proc. Natl. Acad. Sci. USA 70:2916–2920, 1973.

    Google Scholar 

  34. I.M. Goldstein, S.T. Hoffstein and G. Weissmann, Mechanisms of lysosomal enzyme release from human polymorphonuclear leukocytes: effects of phorbol myristate acetate. J. Cell. Biol. 66:647–652, 1975.

    Google Scholar 

  35. I.M. Goldstein, J.K. Horn, H.B. Kaplan and G. Weissmann, Calcium-induced lysozyme secretion form human polymorphonuclear leukocytes. Biochem. Biophys. Res. Commun. 60:807–812, 1974.

    Google Scholar 

  36. S. Hoffstein, R. Soberman, I. Goldstein and G. Weissmann, Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes. J. Cell Biol. 68:781–786, 1976.

    Google Scholar 

  37. E.J. Goetzl and W.C. Pickett, The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs) J. Immunol. 125:1789–1791, 1980.

    Google Scholar 

  38. I.M. Goldstein, C.L. Malmsten, H. Kindahl, H.B. Kaplan, O. Radmark, B. Samuelsson and G. Weissmann, Thromboxane generation by human peripheral blood polymorphonuclear leukocytes. J. Exp. Med. 148:787–792, 1978.

    Google Scholar 

  39. H.E. Claesson, U. Lundberg and C. Malmsten, Serum-coated zymosan stimulates the synthesis of leukotriene B4 in human polymorphonuclear leukocytes. Inhibition by cyclic AMP. Biochem. Biophys Res. Comm. 99:1230–1237, 1981.

    Google Scholar 

  40. B.M. Babior, Oxygen-dependent microbial killing by phagocytes. N. Engl. J. Med. 298: (659–668, 721-725), 1978.

    Google Scholar 

  41. L. Fleck, Ueber Leukergie. Acta Haem 8:282–293, 1952.

    Google Scholar 

  42. J.R. O’Flaherty, H.J. Showell, P.A. Ward and E.L. Becker, A possible role of arachidonic acid in human neutrophil aggregation and degranulation. Am. J. Pathol. 96:799–809, 1979.

    Google Scholar 

  43. R.R. MacGregor, Granulocyte adherence. In: The Cell Biology of Inflammation (Weissmann, G., ed.) Elsevier North Holland Press, Amsterdam and New York, pp. 267–298, 1980.

    Google Scholar 

  44. D. Bainton, Sequential degranulation of the two types of polymorphonuclear leukocyte granules during phagocytosis of microorganisms. J. Cell. Biol. 58:249–264, 1973.

    Google Scholar 

  45. D.F. Bainton, The cells of inflammation: a general view. In: The Cell Biology of Inflammation (Weissmann, G., ed.) Elsevier North Holland Press, Amsterdam and New York, pp. 1–26, 1980.

    Google Scholar 

  46. R.B. Zurier, S. Hoffstein and G. Weissmann, Cytochalasin B: Effect on lysosomal enzyme release from human leucocytes. Proc. Natl. Acad. Sci. USA 70:844-848.

    Google Scholar 

  47. J.E. Smolen, H.M. Korchak and G. Weissmann, Stimulation increases levels of cyclic adenosine-3′, 5′-monophosphate in human polymorphonuclear leukocytes exposed to surface stimuli. J. Clin. Invest. 65:1077–1085, 1980.

    Google Scholar 

  48. J.E. Smolen, H.M. Korchak and G. Weissmann, Initial kinetics of lysosomal enzyme release and superoxide anion generation in human polymorphonuclear leukocytes. Inflammation 4:145–164, 1980.

    Google Scholar 

  49. H.J. Showell, P.H. Naccache, R.I. Sha’afi and E.L. Becker, The effects of extracellular K+, Na+ and Ca++ on lysosomal enzyme secretion from polymorphonuclear leukocytes. J. Immunol. 119:804–811, 1977.

    Google Scholar 

  50. H. Cohen, M. Chovaniec and W. Davies, Activation of the guinea pig granulocyte NAD(P)H-dependent superoxide generating enzyme: localization in a plasma membrane enriched particle and kinetics of activation. Blood 55:3, 355–363, 1980.

    Google Scholar 

  51. H.M. Korchak and G. Weissmann, Changes in membrane potential of human granulocytes antecede the metabolic responses to surface stimulation. Proc. Natl. Acad. Sci. USA 75:3818–3822, 1978.

    Google Scholar 

  52. H.M. Korchak and G. Weissmann, Stimulus-response coupling in the human neutrophil. Transmembrane potential and the role of extracellular Na+. Biochim. Biophys. Acta 601:180–194, 1980.

    Google Scholar 

  53. S. Hoffstein, Ultrastructural demonstration of calcium loss from local regions of the plasma membrane of surface-stimulated human granulocytes. J. Immunol. 123:1395–1402, 1979.

    Google Scholar 

  54. P.H. Naccache, H.J. Showell, E.L. Becker and R.I. Sha’afi, Involvement of membrane calcium in the response of rabbit neutrophils to chemotactic factors as evidenced by the fluorescence of chlorotetracycline. J. Cell Biol. 83:179–186, 1979.

    Google Scholar 

  55. S. Cockcroft, J.P. Bennett and B.D. Gomperts, Stimulus-secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown. Nature 288:275–277, 1980.

    Google Scholar 

  56. G. Weissmann, C. Serhan, H. Korchak, J.E. Smolen, M.J. Brockman and A. Marcus, Neutrophils generate phosphatidic acid, and “endogenous calcium ionophores” before releasing mediators of inflammation. Trans. Assoc. Amer. Phys. (in press), 1981.

    Google Scholar 

  57. R.J. Petroski, P.H. Naccache, E.L. Becker and R.I. Sha’afi, Effect of the chemotactic factor formyl-methionyl-leucyl-phenylalanine and cytochalasin B on the cellular levels of calcium in rabbit neutrophils. F.E.B.S. Lett. 100:161–165, 1979.

    Google Scholar 

  58. P.J. Naccache, J.H. Showell, E.L. Becker and R.I. Sha’afi, Transport of sodium, potassium and calcium across rabbit polymorphonuclear leukocyte membranes. Effect of chemotactic factor. J. Cell Biol. 73:428–444, 1977.

    Google Scholar 

  59. J.E. Smolen and G. Weissmann, Stimuli which provoke secretion of azurophil enzymes from human neutrophils induce increments in adenosine cyclic 3′-5′-monophosphate. Biochim. Biophys. Acta 672:197–206, 1981.

    Google Scholar 

  60. H.B. Kaplan, H.S. Edelson, R. Friedman and G. Weissmann, The roles of degranulation and superoxide anion generation in neutrophil aggregation. J. Immunol. (submitted), 1981.

    Google Scholar 

  61. G. Weissmann, C. Serhan, H.M. Korchak, J.E. Smolen, J. Broekman and A. Marcus, Neutrophils generate phosphatidic acid, and “endogenous calcium ionophore” before releasing mediators of inflammation. Adv. Prost. Thrombox. Res. (in press), 1981.

    Google Scholar 

  62. I.M. Goldstein, S.T. Hoffstein and G. Weissmann, Influence of divalent cations upon complement-mediated enzyme release from human polymorphonuclear leukocytes. J. Immunol. 115:665–670, 1975.

    Google Scholar 

  63. J.E. Smolen and G. Weissmann, The roles of extracellular and intracellular calcium in lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes. Biochim. Biophys. Acta (in press), 1981.

    Google Scholar 

  64. H.M. Korchak, B.A. Eisenstat, S.T. Hoffstein, P.B. Dunham and G. Weissmann, Anion channel blockers inhibit lysosomal enzyme secretion from human neutrophils without affecting generation of superoxide anion. Proc. Natl. Acad. Sci. USA 77:2721–2725, 1980.

    Google Scholar 

  65. A.I. Tauber and E.J. Goetzl, Inhibition of complement-mediated functions of human neutrophils by impermeant stilbene disulfonic acids. J. Immunol. 126:1786–1789, 1981.

    Google Scholar 

  66. G. Weissmann, C. Serhan, H.M. Korchak, J.E. Smolen, J. Broekman and A.S. Marcus, Neutrophils generate phosphatidic acid, and “endogenous calcium ionophore” before releasing mediators of inflammation. Clin. Res. 29:573A, 1981.

    Google Scholar 

  67. C. Serhan, H.M. Korchak, M.J. Broekman, J.E. Smolen, A. Marcus and G. Weissmann, Phosphatidylinositol breakdown and phosphatidic acid accumulation in stimulated human neutrophils: relationship to calcium mobilization and 45Ca uptake. (submitted), 1981.

    Google Scholar 

  68. J.R. Vane, Inhibition of prostaglandin biosynthesis as a mechanism of action for aspirin-like drugs. Nature New Biol. 231:232, 1971.

    Google Scholar 

  69. R.B. Zurier and G. Weissmann, Effect of prostaglandins upon enzyme release from lysosomes and experimental arthritis. In: Prostaglandins in Cellular Biology (Ramwell, P.W. and Pharriss, B.B., eds.) Plenum Publishing Corp., New York, p. 151–172, 1972.

    Google Scholar 

  70. R.B. Zurier, G. Weissmann, S. Hoffstein, S. Kammerman and H.-H. Tai, Mechanisms of lysosomal enzyme release from human leukocytes II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function. J. Clin. Invest. 53:297–309, 1974.

    Google Scholar 

  71. H.R. Bourne, L.M. Lichtenstein, K.L. Melmon, C.S. Henney, Y. Weinstein and G.L. Shearer, Modulation of inflammation and immunity by cyclic AMP. Receptors for vasoactive hormones and mediators of inflammation regulate many leukocyte functions. Science 184:19–28, 1974.

    Google Scholar 

  72. H.R. Bourne, R.I. Lehrer, L.M. Lichtenstein, G. Weissmann and R.B. Zurier, Effects of cholera enterotoxin on adenosine 3′, 5′-monophosphate and neutrophil function: Comparison with other compounds which stimulate leukocyte adenyl cyclase. J. Clin. Invest. 52:698–708, 1973.

    Google Scholar 

  73. R. Zurier, J. Doty and A. Goldenberg, Cyclic AMP response to prostglandin E1 in mononuclear cells from peripheral blood and synovial fluid of patients with rheumatoid arthritis. Prostaglandins 13:25–31, 1977.

    Google Scholar 

  74. R.B. Zurier, S. Hoffstein and G. Weissmann, Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins. Arth. and Rheum. 16:606–618, 1973.

    Google Scholar 

  75. G. Weissmann, J.E. Smolen and H. Korchak, Prostaglandins and inflammation: Receptor/cyclase coupling as an explanation of why PGE’s and PGI2 inhibit functions of inflammatory cells. In: Advances in Prostaglandin and Thromboxane Research (Ramwell, P., Paoletti, R. and Samuelsson, B., eds.) Raven Press, New York, Vol. 8, p. 1637–1653, 1980.

    Google Scholar 

  76. J. Smolen and G. Weissmann, Effects of indomethacin 4, 8, 11, 14-eicosatetraynoic acid, and p-bromophenacyl bromide on lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes. Biochem. Pharmacol. 29:533–538, 1980.

    Google Scholar 

  77. M. Siegel, R. McConnell and P. Cuatrecasas, Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5, 8, 10, 14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway. Proc. Natl. Acad. Sci. USA 76:3774–3778, 1979.

    Google Scholar 

  78. R.B. Zurier and D.M. Sayadoff, Release of prostaglandins from human polymorphonuclear leukocytes. Inflammation 1:93–101, 1975.

    Google Scholar 

  79. J. Morley, M.A. Bray and R.W. Jones, Prostaglandin and thromboxane production by human and guinea-pig macrophages and leukocytes. Prostaglandins 17:729–736, 1979.

    Google Scholar 

  80. W.F. Stenson and C.W. Parker, Metabolism of arachidonic acid in ionophore-stimulated neutrophils. J. Clin. Invest. 64:1457–1465, 1979.

    Google Scholar 

  81. E.J. Goetzl, Vitamin E modulates the lipoxygenation of arachidonic acid in leukocytes. Nature 288:183–185, 1980.

    Google Scholar 

  82. C.E. Walsh, M.B. Waite, M.J. Thomas and L.R. DeChatelet, Release and metabolism of arachidonic acid in human neutrophils. J. Biol. Chem. 256:7228–7234, 1981.

    Google Scholar 

  83. P. Borgeat and B. Samuelsson, Arachidonic acid metabolism in polymorphonuclear leukocytes: Effects of ionophore A23187. Proc. Natl. Acad. Sci. USA 76:2148–2152, 1979.

    Google Scholar 

  84. P. Borgeat and B. Samuelsson, Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. J. Biol. Chem. 254:2643–2646, 1979.

    Google Scholar 

  85. G. Hansson, J.W. Lindgren, S.E. Dahlen, P. Hedqvist and B. Samuelsson, Identification and biological activity of novel ω-oxidized metabolites of leukotriene B4 from human leukocytes. F.E.B.S. Lett. 130:107-112.

    Google Scholar 

  86. O. Radmark, C. Malmsten, B. Samuelsson, R.A. Clark, G. Goto, A. Marfat and E.J. Corey, Leukotriene A: sterochemistry and enzymatic conversion to leukotriene B. Biochem. Biophys. Res. Comm. 92:954–961, 1980.

    Google Scholar 

  87. R. Murphy, S. Hammarstrom and B. Samuelsson, Leukotriene C: a slow-reacting substance from murine mastocytoma cells. Proc. Natl. Acad. Sci. USA 76:4274–4279, 1979.

    Google Scholar 

  88. S. Hammarstrom, R.C. Murphy, D.A. Samuelsson, A. Clark and C. Mioskowski, Identification of the amino acid part. Biochem. Biophys. Res. Commun. 91:1266, 1979.

    Google Scholar 

  89. L. Orning, S. Hammarstrom and B. Samuelsson, Leukotriene D: A slow reacting substance from rat basophilic leukemia cells. Proc. Natl. Acad. Sci. USA 77:4, 2014–2017, 1980.

    Google Scholar 

  90. M.K. Bach, J.R. Brashler, C.D. Brooks, et al. Slow-reacting substance: comparison of some properties of human lung SRA-A and two distinct fractions from ionophore-induced rat mononuclear cells SRS. J. Immunol. 122:160–165, 1979.

    Google Scholar 

  91. R.P. Rubin, L.E. Sink and R.J. Freer, Activation of (arachidonyl) phosphatidylinositol turnover in rabbit neutrophils by the calcium ionophore A23187. Biochem. J. 194:497–505, 1981.

    Google Scholar 

  92. S. Rittenhouse-Simmons, Production of diglyceride from phosphatidylinositol in activated human platelets. J. Clin. Invest. 63:580–587, 1979.

    Google Scholar 

  93. E.A. Kitchen, J.R. Boot and W. Dawson, Chemotactic activity of thromboxane B2, prostaglandins and their metabolites for polymorphonuclear leukocytes. Prostaglandins 16:239–244, 1978.

    Google Scholar 

  94. M.A. Bray, A.W. Ford-Hutchinson and M.J.H. Smith, Leukotriene B4: An inflammatory mediator in vivo. Prostaglandins 22:213–222, 1981.

    Google Scholar 

  95. I. Hafstrom, J. Palmblad, C.L. Malmsten, O. Radmark and B. Samuelsson, Leukotriene B4 — a stereospecific stimulator for release of lysosomal enzymes from neutrophils. F.E.B.S. Lett. 130:146–148, 1981.

    Google Scholar 

  96. H.E. Claesson, U. Lundberg and C.L. Malmsten, Serum-coated zymosan stimulates the synthesis of leukotriene B4 in human polymorphonuclear leukocytes. Inhibition by cyclic AMP. Biochem. Biophys. Res. Comm. 99:1230–1235, 1981.

    Google Scholar 

  97. G.M. Bokoch and P.W. Reed, Stimulation of arachidonic acid metabolism in the polymorphonuclear leukocyte by an N-formylated peptide. J. Biol. Chem. 255:10223–10226, 1980.

    Google Scholar 

  98. C. Serhan, J. Fridovich, E. Goetzl, P.B. Dunham and G. Weissmann, Leukotriene B4 and phosphatidic acid are calcium ionohpores: studies employing arsenazo III in liposomes (submitted).

    Google Scholar 

  99. P.H. Naccache, R.I. Sha’afi, P. Borgeat and E.J. Goetzl, Mono-and dihydroxyeicosatetraenoic acids after calcium homeostasis in rabit neutrophils. J. Clin. Invest. 67:1584–1587, 1981.

    Google Scholar 

  100. R. Maas, J. Oates and A. Brash, Novel products of the lipoxygenation of arachidonic acid. Adv. Prost. Thromb. Res. 9: (in press), 1981.

    Google Scholar 

  101. W. Jubiz, O. Radmark, J.A. Lindgren, C. Malmsten and B. Samuelsson, Novel leukotrienes: products formed by initial oxygenation of arachiodonic acid at C-15. Biochem. Biophys. Res. Comm. 99:976–986, 1981.

    Google Scholar 

  102. W. Hubbard and J.A Oates, personal communication, 1981.

    Google Scholar 

  103. G. Marone, S. Hammarstrom and L.M. Lichtenstein, An inhibitor of lipoxygenase inhibits histamine release from human basophils. Clin. Immunol. & Immunopathol. 17:117–122, 1981.

    Google Scholar 

  104. S.F. Peters, M.I. Siegel, A. Kagey-Sobotka and L.M. Lichtenstein, Lipoxygenase products modulate histamine release in human basophils. Nature 292:455–457, 1981.

    Google Scholar 

  105. H.J. Showell, P.H. Naccache, R.I. Sha’afi and E.L. Becker, Inhibition of rabbit neutrophils lysosomal enzyme secretion, nonstimulated and chemotactic factor stimulated locomotion by nordihydroguaiaretic acid. Life Sciences 27:421–426, 1980.

    Google Scholar 

  106. S.R. Turner, J.A. Campbell and W.S. Lynn, Polymorphonuclear leukocyte chemotaxis toward oxidized lipid componenets of cell membranes. J. Exp. Med. 141:437–446, 1975.

    Google Scholar 

  107. H.D. Perez, B.B. Weksler and I.M. Goldstein, Generation of a chemotactic lipid from arachidonic acid by exposure to a superoxide generating system. Inflammation 4:313–328, 1980.

    Google Scholar 

  108. C. Serhan, P. Anderson, E. Goodman, P. Dunham and G. Weissmann, Phosphatidate and oxidized fatty acids are calcium ionophores: Studies employing arsenzao III in liposomes. J. Biol. Chem. 256:2736–2741, 1981.

    Google Scholar 

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Authors and Affiliations

  1. Division of Rheumatology, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA

    Gerald Weissmann, Charles Serhan, Helen M. Korchak & James E. Smolen

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Weissmann, G., Serhan, C., Korchak, H.M., Smolen, J.E. (1984). Mechanisms of Mediator Release from Neutrophils. In: Acton, R.T., Daniel Lynn, J. (eds) Eukaryotic Cell Cultures. Advances in Experimental Medicine and Biology, vol 172. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9376-8_29

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  • DOI: https://doi.org/10.1007/978-1-4615-9376-8_29

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