Abstract
Proteases are enzymes which cleave peptides. It is generally accepted that proteases are involved in the destruction of proteins and peptide conjugates within the cells and the extracellular space (review Lojda, 1982). In clinical practice the role of the proteases is generally considered as destructive in nature. This evidently bases on a misunderstanding. Proteases are intracellularly stored in primary lysosomes. Substances taken up by the cell via phagocytosis or endocytosis are destructed proteolytically within secondary lysosomes. An intracellular opening of the lysosomes causes a proteolytic destruction of the cell; a phenomenon which induced immediately after its first description the name “suicide bags” for lysosomes (review de Duve and Wattiaux, 1966).
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© 1984 Plenum Press, New York
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Heine, H. (1984). Proteases - Proteases Inhibitors: A Local Cellular Information System. In: Hörl, W.H., Heidland, A. (eds) Proteases. Advances in Experimental Medicine and Biology, vol 167. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9355-3_9
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DOI: https://doi.org/10.1007/978-1-4615-9355-3_9
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