Abstract
Our purpose in studying single-channel currents from excitable membranes is twofold. First, we want to describe the voltage- and time-dependence of the ionic currents that make up the action potential. Second, we want to understand how the channels actually work at the molecular level. When we achieve this we can answer the following questions. What channel properties are responsible for macroscopic properties of membranes (threshold, action potential shape, velocity of propagation, refractory period, spontaneous firing, anesthetic block, and so on)? How do macromolecules flip randomly between conducting and nonconducting states? What causes the kinetics of this random flipping to be voltage-dependent and time-dependent? How do macromolecules select some ions over others? What causes their conductance to be voltage-dependent? How do anesthetics and toxins work?
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References
Conti, F., and Neher, E., 1980, Single channel recordings of K current in squid axon, Nature 285:140–143.
Clay, J. R. and DeFelice, L. J., 1983, Relationship between membrane excitability and single channel open-close kinetics. Biophys. J. 42:151–157.
DeFelice, L. J., 1981, Introduction to Membrane Noise, Plenum Press, New York.
DeFelice, L. J., Adelman, W. J., Jr., Clapham, D. E., and Mauro, A., 1981, Second order admittance in squid axon, in: The Biophysical Approach to Excitable Systems, Plenum Press, New York.
DeFelice, L. J. and Clay, J. R., 1983. Membrane current and membrane potential from single-channel kinetics, in: Single-Channel Recording (B. Sakmann and E. Nelor, eds.) Plenum Press, New York.
Hodgkin, A. L., and Huxley, A. F., 1952, A quantitative description of membrane current and its application to conduction and excitation in nerve, J. Physiol. 117:500–544.
Noble, D., and Tsien, R. W., 1968, The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibers, J. Physiol 195:185–214.
Sigworth, F. J., and Neher, E., 1980, Single Na channel currents observed in cultured rat muscle cells, Nature 287:447–449.
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© 1983 Plenum Press, New York
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DeFelice, L.J., Kell, M.J. (1983). Noise, Impedance, and Single-Channel Currents. In: Chang, D.C., Tasaki, I., Adelman, W.J., Leuchtag, H.R. (eds) Structure and Function in Excitable Cells. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9337-9_9
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DOI: https://doi.org/10.1007/978-1-4615-9337-9_9
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