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Axolemma—Ectoplasm Complex and Mechanical Responses of the Axon Membrane

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Book cover Structure and Function in Excitable Cells

Abstract

The layer of axoplasm located directly underneath the axolemma is rich in fibrillar elements, such as microtubules, neurofilaments, and actin filaments (Metuzals and Izzard, 1969; Metuzals and Tasaki, 1978; Hodge and Adelman, 1980). An extensive destruction of this layer by intracellular perfusion with a solution containing chaotropic anions or proteolytic enzymes is known to lead to a loss of excitability. Therefore, we believe that this layer, which is called the ectoplasm, is an essential part of the excitable membrane.

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References

  • Bean, R. C., Shepherd, W. C., Chan, H., and Eichner, J., 1969, Discrete conductance fluctuations in lipid bilayer protein membranes, J. Gen. Physiol. 53:741–757.

    Article  PubMed  CAS  Google Scholar 

  • Bethe, A., 1920, Nervenpolarisationsbilder und Erregungstheorie, Pflüger’s Arch. Ges. Physiol. 183:289–302.

    Article  Google Scholar 

  • Bethe, A., and Toropoff, T., 1914, Über elektrolytische Vorgänge an Diaphragmen, Z. Phys. Chem. 88:686–742.

    Google Scholar 

  • Brink, F., 1954, The role of calcium ions in neural processes, Pharmacol. Rev. 6:243–298.

    PubMed  CAS  Google Scholar 

  • Franck, U. F., 1956, Models for biological excitation, Prog. Biophys. 6:171–206.

    CAS  Google Scholar 

  • Franck, U. F., 1978a, Chemical oscillations, Angew. Chem. Int. Ed. Engl. 17:1–15.

    Article  Google Scholar 

  • Franck, U. F., 1978b, A quantitative treatment of oscillatory phenomena in coarse-grained ion-exchanger membranes, Electrochimica Acta 23:1081–1091.

    Article  CAS  Google Scholar 

  • Gainer, H., Carbone, E., Singer, I., Sisco, K., and Tasaki, I., 1974, Depolarization induced change in the enzymatic radio-iodination of protein on the internal surface of the squid giant axon membrane, Comp. Biochem. Physiol. 47A:477–484.

    Article  Google Scholar 

  • Gregor, H., 1951, Gibbs Donnan equilibria in ion exchange resin systems, J. Am. Chem. Soc. 73:642–652.

    Article  CAS  Google Scholar 

  • Heilbrunn, L. V., 1938, An Outline of General Physiology, W. B. Saunders, Philadelphia.

    Google Scholar 

  • Hermans, P. H., 1949, Chapter XII Gels, in: Colloid Science (H. R. Kruyt, ed.), Vol. 2, pp. 483–650, Elsevier, New York, Amsterdam.

    Google Scholar 

  • Hill, A. V., 1910, A new mathematical treatment of changes of ionic concentration in muscle and nerve under the action of electric currents, with a theory as to their mode of excitation, J. Physiol. (London) 40:190–224.

    CAS  Google Scholar 

  • Hill, S. E., and Osterhout, W. J. V., 1938, Calculation of bioelectric potentials, J. Gen. Physiol. 21:541–556.

    Article  PubMed  CAS  Google Scholar 

  • Hodge, A. J., and Adelman, W. J., Jr., 1980, The neuroplasmic network in Loligo and Hermissenda neurons, J. Ultrastruct. Res. 70:220–241.

    Article  PubMed  CAS  Google Scholar 

  • Hodgkin, A. L., and Huxley, A. F., 1952, A quantitative description of membrane current and its application to conduction and excitation in nerve, J. Physiol. (London) 117:500–544.

    CAS  Google Scholar 

  • Iwasa, K., and Tasaki, I., 1980, Mechanical changes in squid giant axons associated with production of action potentials, Biochem. Biophys. Res. Commun. 95:1328–1331.

    Article  PubMed  CAS  Google Scholar 

  • Iwasa, K., and Tasaki, I., 1981, Rapid pressure changes of the squid giant axon accompanied by prolonged action potentials, Biol. Bull., 161:346.

    Google Scholar 

  • Katchalsky, A., and Zwick, M., 1955, Mechanochemistry and ion exchange, J. Polymer Sci. 17:221–234.

    Article  Google Scholar 

  • Kawai, H., 1969, The piezoelectricity of poly (vinylidene fluoride), Jpn. J. Appl. Phys. 8:975–976.

    Article  CAS  Google Scholar 

  • Kressman, T. R. E., and Kitchner, J. A., 1949, Cation exchange with a synthetic phenosulphonate resin. Part III. Equilibria with large organic cations, J. Chem. Soc. 1949:1208–1210.

    Article  Google Scholar 

  • Loeb, J., 1906, The Dynamics of Living Matter, Columbia University Press, New York.

    Google Scholar 

  • Meares, P., and Page, K. R., 1972, Rapid force-flux transitions in highly porous membranes, Phil. Trans. 272:1–46.

    Article  CAS  Google Scholar 

  • Metuzals, J., and Izzard, C. S., 1969, Spatial patterns of threadlike elements in the axoplasm of the giant nerve fiber of the squid (Loligo pealii L.) as disclosed by differential interference microscopy and by electron microscopy, J. Cell Biol. 43:456–479.

    Article  PubMed  CAS  Google Scholar 

  • Metuzals, J., and Tasaki, I., 1978, Subaxolemma filamentous network in the giant nerve fiber of the squid (Loligo pealei L.) and its possible role in excitability, J. Cell Biol. 78:597–621.

    Article  PubMed  CAS  Google Scholar 

  • Murayama, N., Nakamura, K., Obara, H., and Segawa, M., 1976, The strong piezoelectricity in polyvinylidine fluoride (PVDF), Ultrasonics (January) 15–23.

    Google Scholar 

  • Nernst, W., 1908, Zur Theorie des elektrischen Reizes, Pflüger’s Arch. Ges. Physiol. 122:275–314.

    Article  Google Scholar 

  • Pant, H. C., Terakawa, S., Baumgold, J., Tasaki, I., and Gainer, H., 1978, Protein release from the internal surface of the squid giant axon membrane during excitation and potassium depolarization, Biochim. Biophys. Acta 513:132–140.

    Article  PubMed  CAS  Google Scholar 

  • Robinson, A. L., 1978, Flexible PVF2 film: An exceptional polymer for transducer, Science 200:1371–1374.

    Article  PubMed  CAS  Google Scholar 

  • Robinson, R. A., and Stokes, R. H., 1959, Electrolyte Solutions, Butterworths, London.

    Google Scholar 

  • Tasaki, I., 1982, Physiology and Electrochemistry of Nerve Fibers, Academic Press, New York.

    Google Scholar 

  • Tasaki, I., and Hagiwara, S., 1957, Demonstration of two stable potential states in the squid giant axon under tetraethylammonium chloride, J. Gen. Physiol. 40:859–885.

    Article  PubMed  CAS  Google Scholar 

  • Tasaki, I., and Iwasa, K., 1980, Swelling of nerve fibers during action potentials, Upsala J. Med. Sci. 85:211–215.

    Article  PubMed  CAS  Google Scholar 

  • Tasaki, I., Watanabe, A., and Lerman, L., 1967, Role of divalent cations in excitation of squid giant axons, Am. J. Physiol. 213:1465–1474.

    PubMed  CAS  Google Scholar 

  • Tasaki, I., Iwasa, K., and Gibbons, R. C., 1981, Mechanical changes in crab nerve fibers during action potentials, Jpn. J. Physiol. 30:897–905.

    Article  Google Scholar 

  • Teorell, T., 1959, Electrokinetic membrane processes in relation to properties of excitable tissues, II, Some theoretical considerations, J. Gen. Physiol. 42:847–862.

    Article  PubMed  CAS  Google Scholar 

  • Teorell, T., 1962, Excitability phenomena in artificial membranes, Biophys. J. (Suppl.) 2:27–52.

    Article  PubMed  CAS  Google Scholar 

  • Tobias, J. M., 1964, A chemically specified molecular mechanism underlying excitation in nerve: A hypothesis, Nature (London) 203:13–17.

    Article  CAS  Google Scholar 

  • White, G. L., Schellhase, H. U., and Hawthorne, J. N., 1974, Phosphoinositide metabolism in rat superior cervical ganglion, vagal and phrenic nerve; effects of electrical stimulation and various blocking agents, J. Neurochem. 22:149–158.

    Article  PubMed  CAS  Google Scholar 

  • Williams, R. J. P., 1970, The biochemistry of sodium, potassium, magnesium and calcium, Quart. Rev. Chem. Soc. (Lond.) 24:331–365.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of Neurobiology, NIMH, Bethesda, Maryland, 20205, USA

    I. Tasaki & K. Iwasa

  2. Marine Biological Laboratory, Woods Hole, Massachusetts, 02543, USA

    I. Tasaki & K. Iwasa

Authors
  1. I. Tasaki
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  2. K. Iwasa
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine and Rice University, Houston, Texas, USA

    Donald C. Chang

  2. National Institute of Mental Health, National Institutes of Health, Bathesda, Maryland, USA

    Ichiji Tasaki

  3. The Marine Biological Laboratory, Woods Hole, Massachusetts, USA

    Ichiji Tasaki

  4. National Institute of Neurological and Communication Disorders and Stroke, National Institutes of Health at the Marine Biological Laboratory, Woods Hole, Massachusetts, USA

    William J. Adelman Jr.

  5. Texas Southern University, Houston, Texas, USA

    H. Richard Leuchtag

  6. University of Texas Medical Branch, Galveston, Texas, USA

    H. Richard Leuchtag

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© 1983 Plenum Press, New York

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Tasaki, I., Iwasa, K. (1983). Axolemma—Ectoplasm Complex and Mechanical Responses of the Axon Membrane. In: Chang, D.C., Tasaki, I., Adelman, W.J., Leuchtag, H.R. (eds) Structure and Function in Excitable Cells. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9337-9_15

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  • DOI: https://doi.org/10.1007/978-1-4615-9337-9_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9339-3

  • Online ISBN: 978-1-4615-9337-9

  • eBook Packages: Springer Book Archive

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