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Diarrhea and Malnutrition pp 45–72Cite as

The Epidemiology and Pathophysiology of Invasive Bacterial Diarrheas

With a Note on Biological Considerations in Control Strategies

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Abstract

A fundamental distinction among enteric bacterial pathogens involves the capacity of some, but not all, to invade intestinal epithelial cells and multiply within the gut mucosa.1 This property not only affects the epidemiology of these infections and their clinical presentation but also imposes biological constraints on attempts to control their spread among susceptible populations. This paper will consider the epidemiology, pathogenesis, clinical manifestations, and potential nutritional consequences of four distinctive invasive bacterial agents of gastroenteritis, the shigellas, the salmonellas (including the causative agents of the enteric fever syndrome), Yersinia enterocolitica, and Campylobacter jejuni, and will attempt to evaluate control strategies based on the biological attributes of the organisms.

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  1. Division of Geographic Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA

    Gerald T. Keusch

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Editors and Affiliations

  1. Ford Foundation, New Delhi, India

    Lincoln C. Chen

  2. Massachustts Institute of Technology, USA

    Nevin S. Scrimshaw (Institute Professor, Director, Senior Adviser) (Institute Professor, Director, Senior Adviser)

  3. MIT/Harvard International Food and Nutrition Program, USA

    Nevin S. Scrimshaw (Institute Professor, Director, Senior Adviser) (Institute Professor, Director, Senior Adviser)

  4. World Hunger Program, United Nations University, USA

    Nevin S. Scrimshaw (Institute Professor, Director, Senior Adviser) (Institute Professor, Director, Senior Adviser)

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Keusch, G.T. (1983). The Epidemiology and Pathophysiology of Invasive Bacterial Diarrheas. In: Chen, L.C., Scrimshaw, N.S. (eds) Diarrhea and Malnutrition. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9284-6_3

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