Abstract
In mammalian mitochondria, as well as in bacteria, respiration is coupled to H+ ion extrusion due to operation of the redox-driven H+ pumps. This leads1,2 to formation of a H+ electrochemical gradient, Δμ̃H. Two rates of respiration are distinguished, that of fully uncoupled mitochondria and that of coupled mitochondria in the stationary state, denoted as state 4 or static head. In uncoupled mitochondria the respiratory rate Je is limited purely by the kinetics of e- transfer in the respiratory chain. On the other hand in coupled mitochondria the respiratory rate in static head, J she , is limited partly by the kinetics of e- transfer and partly by the thermodynamics of the H+ pump (energetic control). The nature of the energetic control requires some clarification.
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© 1982 Plenum Press, New York
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Azzone, G.F., Pietrobon, D., Walz, D. (1982). The Molecular Slipping in the Redox-Driven H+ Pumps. In: Bossa, F., Chiancone, E., Finazzi-Agrò, A., Strom, R. (eds) Structure and Function Relationships in Biochemical Systems. Advances in Experimental Medicine and Bioligy, vol 148. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9281-5_15
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DOI: https://doi.org/10.1007/978-1-4615-9281-5_15
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