Abstract
The concept of a gonadal peptide regulating the secretion of gonadotropins was originally proposed by McCullagh in 1932. This hypothetical material, which he called inhibin, was deduced as being a nonsteroidal substance, probably protein or polypeptidic in nature, that is released into general circulation and acts specifically on the pituitary gland, selectively inhibiting the secretion of FSH, but not that of LH. Such preferential regulation of gonadotropin secretion has generated a great deal of attention during the past decade. Inhibin, or inhibin-like activities, have been reported in extracts of testis (Lee et al., 1976; Keogh et al., 1976; Moodbidri et al., 1976; Nandini et al., 1976; Baker et al., 1976), spermatozoa (Lugaro et al., 1974), rete testis fluid (Setchell and Sirianthsinghji, 1972; Setchell and Jacks, 1974), seminal plasma (Franchimont et al., 1975; Chari et al., 1978), and ovarian follicular fluid (Hopkinson et al., 1977; de Jong and Sharpe, 1976; Welschen et al., 1977; Marder et al., 1977; Schwartz and Channing, 1977).
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References
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Ying, SY., Ling, N.C., Esch, F.S., Guillemin, R., Watkins, W.B. (1982). Purification of Gonadostatin from Bovine Seminal Plasma (BSP). In: Channing, C.P., Segal, S.J. (eds) Intraovarian Control Mechanisms. Advances in Experimental Medicine and Biology, vol 147. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9278-5_7
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DOI: https://doi.org/10.1007/978-1-4615-9278-5_7
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