Abstract
Inhibin, a hormone first suggested by McCullagh (1932), has only come under intensive study in the last decade. The generalization of this testicular factor to that of a gonadal factor by de Jong and Sharpe (1976) extended its significance and increased the need to learn more about it. Inhibin (McCullagh, 1932) has been named inhibin-m or inhibin-f (Williams et al., 1978), folliculo-statin (Schwartz and Charming, 1977) and gonadostatin (Ying et al., 1981). We prefer and suggest the general adoption of the name gonadostatin (GnS) because it is independent of sex, it implies target (gonadotrophic cell) as well as origin (the gonads). The most pressing need in gonadostatin research is to isolate and characterize this molecule and develop assay procedures which will allow direct study of this putative hormone. At present much that we have learned of its physiology is indirect and derives from its one clearly defined effect, depression of plasma FSH. Initially bio-assays used whole animals such as immature castrate males (Nandini et al., 1976) and metestrous ovariectomized female rats (Marder et al., 1977).
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Williams, A.T., Lipner, H. (1982). Partial Purification of Porcine Follicular Fluid Gonadostatin. In: Channing, C.P., Segal, S.J. (eds) Intraovarian Control Mechanisms. Advances in Experimental Medicine and Biology, vol 147. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9278-5_6
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DOI: https://doi.org/10.1007/978-1-4615-9278-5_6
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