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Actions of Hormones and Other Factors Upon Oocyte Maturation

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Intraovarian Control Mechanisms

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 147))

Abstract

The mammalian oocyte is arrested in the dictyate state of meiosis from shortly before or at the time of birth until 1–2 days prior to ovulation. Under the influence of the preovulatory LH surge the oocyte in the large preovulatory follicle destined to ovulate undergoes maturation. The germinal vesicle breaks down and the first polar body is extruded. This first meiotic maturation must be completed in order to render the oocyte fertilizable. The physiological mechanism responsible for keeping the oocyte in the state of meiotic arrest is unknown. It is well documented that if the oocytes are removed from medium or large-sized follicles and cultured they resume meiotic maturation before they normally would in vivo. (Reviewed by Tsafriri, 1978; Channing et al., 1980; Schuetz, 1974.) Addition of a low molecular weight fraction of follicular fluid (FF1) (porcine, human, bovine) can inhibit the resumption of meiosis of cultured cumulus-enclosed porcine (Tsafriri and Channing, 1975; Tsafriri et al., 1976; and Stone et al., 1978), rat (Tsafriri et al., 1977; Pomerantz, Tsafriri, and Channing, 1979), and hamster (Gwatkin and Andersen, 1976) oocytes suggesting that a meiotic inhibitor is present in follicular fluid.

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Author information

Authors and Affiliations

  1. Department of Physiology, University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, Maryland, 21201, USA

    Cornelia P. Channing, In-Ha Bae, Valerie W. Evans & Susan J. Atlas

  2. Department of Biological Chemistry, University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, Maryland, 21201, USA

    Seymour H. Pomerantz

Authors
  1. Cornelia P. Channing
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  2. Seymour H. Pomerantz
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  3. In-Ha Bae
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  4. Valerie W. Evans
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  5. Susan J. Atlas
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Editor information

Editors and Affiliations

  1. Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland, USA

    Cornelia P. Channing

  2. Population Division, The Rockefeller Foundation, New York, New York, USA

    Sheldon J. Segal

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© 1982 Plenum Press, New York

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Channing, C.P., Pomerantz, S.H., Bae, IH., Evans, V.W., Atlas, S.J. (1982). Actions of Hormones and Other Factors Upon Oocyte Maturation. In: Channing, C.P., Segal, S.J. (eds) Intraovarian Control Mechanisms. Advances in Experimental Medicine and Biology, vol 147. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9278-5_12

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  • DOI: https://doi.org/10.1007/978-1-4615-9278-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9280-8

  • Online ISBN: 978-1-4615-9278-5

  • eBook Packages: Springer Book Archive

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