Skip to main content

Meiotic Arresting Substance Separated from Porcine Ovarian Granulosa Cells and Hypothetical Arresting Mechanism of Meiosis

  • Chapter
Intraovarian Control Mechanisms

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 147))

Abstract

In mammals, oogonia enter prophase of the first meiotic division in prenatal life, and shortly after birth, all oocytes are arrested in a late prophase known as the dictyate stage, and when an oocyte in an ovary reaches the end of its growth period, it contains a single large nucleus called the germinal vesicle (Franchi et al., 1962). It is now generally accepted that the resumption of the arrested first meiotic division occurs as a result of the surge of luteinizing hormone (LH) at each ovarian cycle (Shuetz, 1969; Tsafriri, 1978a), although the ability to complete the first meiotic division is related as well to the stage of follicular development (Tsafriri and Channing, 1975a; Sorensen and Wassarman, 1976).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Biggers, J. D. , 1973, Oogenesis and ovum maturation, in: “The Regulation of Mammalian Reproduction,” S. J. Segal, R. Crozier, P. A. Corfman, and P. G. Condliffe, eds., pp. 273–283, Charles C. Thomas, Springfield, Illinois.

    Google Scholar 

  • Chang, M. C., 1955, The maturation of rabbit oocytes in culture and their maturation, activation, fertilization, and subsequent development in fallopian tube, J. Exp. Zool., 128:378.

    Article  Google Scholar 

  • Channing, C. P., Schaerf, F. W., Anderson, L. D., and Tsafriri, A., 1980, Ovarian follicular and luteal physiology, in: “International Review of Physiology, Vol. 22, Reproductive Physiology III,” R. O. Greep, eds., pp. 117–201, University Park Press, Baltimore.

    Google Scholar 

  • Dekel, N., Hillensjö, T., and Kraicer, P. F., 1979, Maturational effects of gonadotropins on the cumulus-oocyte complex of the rat, Biol. Reprod., 20:191.

    Article  CAS  Google Scholar 

  • Dekel, N., and Kraicer, P. F., 1978, Induction in vitro of mucifica-tion of rat cumulus oophorus by gonadotropins and c-AMP, Endocrinology, 102:1797.

    Article  CAS  Google Scholar 

  • Dekel, N., Kraicer, P. F., Phillips, D. M., Sanchez, R., and Segal, S. J,, 1978, Cellular association in the rat oocyte-cumulus cell complex: morphology and ovulatory changes, Gamate Res., 1:47.

    Article  Google Scholar 

  • Dekel, N., and Phillips, D. M., 1979, Maturation of the rat cumulus oophorus: A scanning electron microscopic study, Biol. Reprod., 21:9.

    Article  CAS  Google Scholar 

  • Edwards, R. G., 1962, Meiosis in ovarian oocytes of adult mammals, Nature, 196:446.

    Article  Google Scholar 

  • Eppig, J. J., 1979a, FSH stimulates hyaluronic acid synthesis by oocyte-cumulus cell complexes from mouse preovulatory follicles, Nature, 281:483.

    Article  CAS  Google Scholar 

  • Eppig, J. J., 1979b, Gonadotropin stimulation of the expansion of cumulus oophori isolated from mice: general conditions for expansion in vitro, J. Exp. Zool., 208:111.

    Article  CAS  Google Scholar 

  • Eppig, J. J., 1980, Role of serum in FSH stimulated cumulus expansion by mouse oocyte-cumulus cell complexes in vitro, Biol. Reprod., 22:629.

    CAS  Google Scholar 

  • Foote, W. D., and Thibault, C., 1969, Recherches expérimentales sur la maturation in vitro des ovecytes de truie et de veau, Ann. Biol. Anim. Biochim. Biophys., 9:329.

    Article  Google Scholar 

  • Franchi, L. L., Mandl, A. M., and Zuckermann, S., 1962, NThe development of the ovary and the process of oogenesis, ±n: “The Ovary, Vol. 1,” S. Zuckermann, ed., pp. 1–88, Academic Press, New York.

    Google Scholar 

  • Gwatkin, R. B. L., and Andersen, O. F., 1976, Hamster oocyte maturation in vitro: Inhibition by follicular components, Life Sci., 19:527.

    Article  CAS  Google Scholar 

  • Hillensjö, T., Batta, S. K., Schwartz-Kripner, A., Wentz, A. C., Igarashi, Y., and Yaoi, Y., 1975, Growth-enhancing protein obtained from cell surface of cultured fibroblasts, Nature, 254:248.

    Article  Google Scholar 

  • Jagiello, G., Graffeo, J., Ducayen, M., and Presser, R., 1977, Further studies of inhibitors of in vitro mammalian oocyte maturation, Fertil. Steril., 28:476.

    CAS  Google Scholar 

  • Kondo, K., and Sakai, H., 1971, Demonstration and preliminary characterization of reaggregation-promoting substances from embryonic sea urchin cells, Devel. Growth Differ., 13:1.

    Article  CAS  Google Scholar 

  • Pincus, G., and Enzmann, E. V., 1935, The comparative behavior of mammalian eggs in vivo and in vitro, I. The activation of ovarian eggs, J. Exp. Med., 62:665.

    Article  CAS  Google Scholar 

  • Sato, E., Furubayashi, R., and Ishibashi, T., 1978, Physicochemical characteristics of the meiotic arresting substance obtained from cell surface of porcine granulosa cells, Jpn. J. Anim. Reprod., 24:59.

    Article  CAS  Google Scholar 

  • Sato, E., Iritani, A., and Nishikawa, Y., 1977a, Factors involving in maturation of pig and cattle follicular oocytes cultured in vitro, Jpn. J. Anim. Reprod., 23:12.

    Article  Google Scholar 

  • Sato, E., Iritani, A., and Nishikawa, Y., 1977b, Effects of energy-sources on oocyte maturation in pig and cattle, Jpn. J. Zoo-tech. Sci., 48:333.

    Google Scholar 

  • Sato, E., Iritani, A., and Nishikawa, Y., 1978a, Maturation and activation of cattle follicular oocytes cultured in vitro, Jpn. J. Zootech. Sci., 49:236.

    Google Scholar 

  • Sato, E., Iritani, A., and Nishikawa, Y., 1978b, Rate of maturation division of pig follicular oocytes cultured in vitro, Jpn. J. Zootech. Sci., 49:400.

    Google Scholar 

  • Sato, E., Iritani, A., and Nishikawa, Y., 1979, “Formation of nucleus” and “cleavage” of pig follicular oocytes cultured in vitro, Jpn. J. Anim. Reprod., 25:95.

    Google Scholar 

  • Sato, E., Iritani, A., and Nishikawa, Y., 1980, Mechanism of inhibition of germinal vesicle breakdown in pig follicular oocytes with special reference to the role of granulosa cell layer, Jpn. J. Fertil. Steril., 25:229.

    Google Scholar 

  • Sato, E., Iritani, A., and Nishikawa, Y., 1982, Analysis of the hours required for germinal vesicle breakdown in pig and cattle oocytes, Jpn. J. Fertil. Steril., 27:112.

    Google Scholar 

  • Sato, E., and Ishibashi, T., 1977, Meiotic arresting action of the substance obtained from cell surface of porcine ovarian granulosa cells, Jpn. J. Zootech. Sci., 48:22.

    Google Scholar 

  • Schuetz, A. W., 1969, Oogensis: processes and their regulation, Advances in Reprod. Physiol., 4:99.

    Google Scholar 

  • Sorensen, R. A., and Wassarman, P. M., 1976, Relationship between growth and meiotic maturation of the mouse oocyte, Dev. Biol., 50:531.

    Google Scholar 

  • Stone, S. L., Pomerantz, S. H., Schwartz-Kripner, A., and Channing, C. P., 1978, Inhibition of oocyte maturation from porcine follicular fluid: Further purification and evidence for reversible action, Biol. Reprod., 19:585.

    Google Scholar 

  • Tsafriri, A., 1978a, Oocyte maturation in mammals, in.: “The Vertebrate Ovary,” R. E. Jones, ed., pp. 409–442, Plenum Press, New York.

    Google Scholar 

  • Tsafriri, A., 1978b, Inhibition of nuclear maturation of isolated rat oocytes by follicular consituents, Ann. Biol. Anim. Bio-chim. Biophys., 18:523.

    Google Scholar 

  • Tsafriri, A., 1979, Mammalian oocyte maturation: model systems and their physiological relevance, in: “Ovarian Follicular and Corpus Luteum Function,” Advances in Experimental Medicine and Biology, Vol. 112, C. P. Channing, J. M. Marsh, and W. A. Sadler, eds., p. 269, Plenum Press, New York.

    Google Scholar 

  • Tsafriri, A., and Channing, C. P., 1975a, Influence of follicular maturation and culture conditions on the meiosis of pig oocytes in vitro, J. Reprod. Fert., 43:149.

    Google Scholar 

  • Tsafriri, A., and Charming, C. P., 1975b, An inhibitory influence of granulosa cells and follicular fluid upon porcine oocyte meiosis in vitro, Endocrinology, 96:922.

    Article  CAS  Google Scholar 

  • Tsafriri, A., Channing, C. P., Pomerantz, S. H., and Lindner, H. R., 1977, Inhibition of maturation of isolated rat oocytes by porcine follicular fluid, J. Endocrinol., 75:285.

    Article  CAS  Google Scholar 

  • Tsafriri, A., Pomerantz, S. H., and Channing, C. P., 1976, Inhibition of oocyte maturation by porcine follicular fluid: Partial characterization of the inhibitor, Biol. Reprod., 14:511.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Sato, E., Ishibashi, T., Iritani, A. (1982). Meiotic Arresting Substance Separated from Porcine Ovarian Granulosa Cells and Hypothetical Arresting Mechanism of Meiosis. In: Channing, C.P., Segal, S.J. (eds) Intraovarian Control Mechanisms. Advances in Experimental Medicine and Biology, vol 147. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9278-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9278-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9280-8

  • Online ISBN: 978-1-4615-9278-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics