Advertisement

A Rheological Study of Mucus - Antibiotic Interactions

  • David T. Brown
  • Christopher Marriott
  • Malcolm F. Beeson
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)

Abstract

Antibiotic therapy is commonly used both during acute exacerbations of bronchitis and prophylactically. Unless the antibiotic is instilled directly into the lung, then the transfer of the drug across the blood-bronchial barrier is a critical step. The maintenance of a homogeneous bactericidal or bacteriostatic concentration in the mucus is dependent upon the ability of the drug to diffuse through the mucus gel. The thickened hypersecretory mucus which is produced during infection may present a barrier to diffusion and this in turn may be affected by the antibiotic itself. Earlier work (Marriott and Kellaway, 1975) has indicated that tetracyclines exert a thickening effect on sputum. In this study we have examined the effect of a wide range of antibiotics on the rheological and mucociliary transport properties of a purified glycoprotein gel (Marriott et al, 1979).

Keywords

Mucociliary Clearance Rheological Study Huggins Constant Bronchial Mucus Frog Palate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Eirich, F. and Riseman, J., 1949, Some remarks on the first interaction coefficient of the viscosity-concentration equation, J. Polym. Sci., 4: 417.CrossRefGoogle Scholar
  2. Kellaway, I.W. and Marriott, C., 1978, Influence of drug hydro-phobicity on the binding of tetracyclines to albumin, Canad. J. Pharm. Sci., 30: 90.Google Scholar
  3. Marriott, C. and Kellaway, I.W., 1975, The effect of tetracyclines on the viscoelastic properties of bronchial mucus, Biorheology, 12: 391.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • David T. Brown
    • 1
  • Christopher Marriott
    • 1
    • 2
  • Malcolm F. Beeson
    • 1
    • 3
  1. 1.Department of PharmacyUniversity of NottinghamNottinghamUK
  2. 2.Department of PharmacyBrighton PolytechnicBrightonUK
  3. 3.Beecham Pharmaceuticals Research DivisionGreat BurghUK

Personalised recommendations