Modification of the Rheological Properties of Mucus by Drugs

  • Christopher Marriott
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)


The rheological properties of mucus secretions from various sites in the body are related to their particular physiological function. Although in normal circumstances the body produces secretions with optimal rheological properties to fulfil such functions, during disease the mucus produced may be too thick or too thin and in both cases may behave sub-optimally. In such situations it becomes attractive to administer chemical agents or drugs, either locally or systemically, which modify the rheological properties in an attempt to correct function. Furthermore, in certain cases it may be desirable to artificially manipulate the consistency of the mucus in order to produce a specific effect.


Rheological Property Creep Compliance Chlormadinone Acetate Bronchial Mucus Cysteine Derivative 
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  1. Brown, D.T., 1980, Ph.D. Thesis, University of Nottingham.Google Scholar
  2. Chodosh, S., 1980, Acetylcysteine in chronic bronchitis, Eur. J. Respir. Dis., 61(S111): 90.Google Scholar
  3. Crowther, R.S. and Marriott, C., 1979, Cation induced changes in the biophysical properties of mucins, J. Pharm. Pharmac., 31: 89P.CrossRefGoogle Scholar
  4. Davis, S.S. and Deverell, L.C., 1977, Rheological factors in mucociliary clearance, Mod. Probl. Paediat., 19: 207.Google Scholar
  5. Forstner, J.F. and Forstner, G.G., 1975, Calcium binding to intestinal goblet cell mucin, Biochim. Biophys. Acta, 386: 283.PubMedGoogle Scholar
  6. Gelman, R.A. and Meyer, F.A., 1979, Mucociliary transference rate and mucus viscoelasticity dependence on dynamic storage and loss modulus, Am. Rev. resp. Dis., 120: 553.PubMedGoogle Scholar
  7. Hirsch, S.R., Zastrow, J.E. and Kory, R.C., 1969, Sputum liquefying agents: a comparative in vitro evaluation, J. Lab. Clin. Med., 74: 346.PubMedGoogle Scholar
  8. Khan, M.A., Wolf, D.P. and Litt, M., 1976, Effect of mucolytic agents on the rheological properties of tracheal mucus, Biochim. Biophys. Acta, 444: 369.PubMedCrossRefGoogle Scholar
  9. King, M., Engel, L.A. and Macklem, P.T., 1979, Effect of pentobarbital anesthesia on rheology and transport of canine tracheal mucus, J. Appl. Physiol., 46: 504.PubMedGoogle Scholar
  10. Kosasky, H.J., Kopito, E.L., Somers, H.S. and Shwachman, H., 1973, Changes in water and electrolytes in human cervical mucus during treatment with chlormadinone acetate, Fertil. Steril., 24: 507.PubMedGoogle Scholar
  11. Lieberman, J., 1968, Measurement of sputum viscosity in a coneplate viscometer, Amer. Rev. resp. Dis., 97: 662.PubMedGoogle Scholar
  12. Lightowler, J.E. and Lightowler, N.M., 1971, Comparative mucolytic studies on dithiothreitol, N-acetylcysteine and L-cysteine on human respiratory mucus in vitro and their effects on the role of flow of mucus in the exposed trachea of the rat on topical application, Arch. int. Pharmacodyn., 189: 53.PubMedGoogle Scholar
  13. Martin, R., Litt, M. and Marriott, C., 1980, The effect of mucolytic agents on the rheologic and transport properties of canine tracheal mucus, Amer. Rev. resp. Dis., 121: 495.PubMedGoogle Scholar
  14. Martin, G., Marriott, C. and Kellaway, I.W., 1981, The interaction of progesterone with mucus glycoproteins, Pharm. Acta Helv., 56: 5.PubMedGoogle Scholar
  15. Marriott, C., Beeson, M.F. and Brown, D.T., 1981a, Biopolymer induced changes in mucus viscoelasticity, this conference.Google Scholar
  16. Marriott, C., Brown, D.T. and Beeson, M.F., 1981b, Evaluation of mucolytic activity using a purified mucus glycoprotein gel, this conference.Google Scholar
  17. Marriott, C. and Kellaway, I.W., 1975, The effect of tetracyclines on the viscoelastic properties of bronchial mucus, Biorheology, 12: 391.PubMedGoogle Scholar
  18. Marriott, C. and Richards, J.H., 1974, The effects of storage and of potassium iodide, urea, N-acetylcysteine and Triton X-100 on the viscosity of bronchial mucus, Brit. J. Dis. Chest, 68: 171.PubMedCrossRefGoogle Scholar
  19. Marriott, C., Shih, C.K. and Litt, M., 1979, Changes in the gel properties of tracheal mucus induced by divalent cations, Biorheology, 16: 331.PubMedGoogle Scholar
  20. McNiff, E., Clemente, E. and Fung, H.L., 1975, In vitro comparison of the mucolytic activity of sodium metabisulfite, N-acetylcysteine and dithiothreitol, Drug Dev.Comm., 1: 507.Google Scholar
  21. Shih, C.K., Litt, M., Khan, M.A. and Wolf, D.P., 1977, Effect of non-dialysable solids concentration and viscoelasticity on ciliary transport of tracheal mucus., Am. Rev. resp. Dis., 115: 989.PubMedGoogle Scholar
  22. Tabachnik, N.F., Peterson, C.M. and Cerami, A., 1980, Studies on the reduction of sputum viscosity in cystic fibrosis using an orally absorbed protected thiol, J. Pharmacol. Exp. Ther., 214: 246.PubMedGoogle Scholar
  23. Verstraeten, J -M., 1980, Mucolytic treatment in chronic airways obstruction. Double-blind clinical trial with acetylcysteine, bromhexine and placebo., Eur. J. Respir. Dis., 61(S111): 77.Google Scholar
  24. Ziment, I., 1978, Respiratory Pharmacology and Therapeutics, W.B. Saunders, Philadelphia.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Christopher Marriott
    • 1
  1. 1.Department of PharmacyBrighton Polytechnic MoulsecoombBrightonUK

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