Abstract
Mucociliary clearance is responsible for removing inhaled deposited organisms, particles and for clearing cellular debris and waste products from the airways of the lung. Within the mucus coating are also phagocytic, enzimatic and immunological defenses that are, in large part responsible for keeping the lung free from infection. Changes in the depth of mucus lining or its rate of transport in the various airway generations could compromise any of these defense mechanisms.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Albert, R.E., Lippmann, M., Peterson, H.T., Berger, J., Sandborn, K., and Bohning, D. (1973). Bronchial deposition and clearance of aerosols. Arch. Int. Med. 131: 115–127.
Lee, P.S., Gerrity, T.R., Hass, F.J., and Lourenco, R.V. (1979). A Model for Tracheobronchial Clearance of Inhaled Particles in Man and a Comparison with Data. IEEE Trans. Biomed. Eng., BME-26(11) 624–630.
Leikauf, G., Yeates, D.B., Wales, K.A., Albert, R.E., and Lippmann, M. (1981). Effects of Sulfuric Acid Aerosol on Respiratory Mechanics and Mucociliary Particle Clearance in Healthy Nonsmoking Adults. Arch. Environ. Health — In Press.
Spektor, D.M., Leikauf, G.D., and Lippmann, M. (1980). Tracheobronchial Mucociliary Particle Transport in Asymptomatic Asthmatics. Amer. Rev. Resp. Dis., 121 (4 part 2), 409.
Venizelos, P.C., Gerrity, T.R., and Yeates, D.B. (1981). Human Response of Mucociliary Clearance to Alcohol Administration. Arch. Environ., Health — In Press.
Wales, K.A., Petrow, H.G., and Yeates, D.B. (1980). Production of Tc-99m Labelled Iron Oxide Aerosols for Human Lung Deposition and Clearance Studies. International Journal of Applied Radiation and Isotopes. 13, 689–694.
Wilkey, D.D., Lee, P.S., Hass, F.J., Gerrity, T.R., Yeates, D.B., and Lourenco, R.V. (1980). Mucociliary Clearance of Deposited Particles from the Human Lung. Arch. Environ. Health. 35 (5) 294–303.
Yeates, D.B., and Aspin, N. (1978). A Mathematical Description of the airways of the Human Lungs. Respiration Physiology: 32: 91–103.
Yeates, D.B., Pitt, B.R., Spektor, D.M., Karron, G.A., and Albert, R.E. (1981a). Coordination of Mucociliary Transport in the Human Trachea and Intrapulmonary Airways. J. Appl. Physiol. — In Press.
Yeates, D.B., Gerrity, T.R., and Garrard, C.S. (1981b). Characteristics of Tracheobronchial Deposition and Clearance in Man. In: Inhaled Particles V, Ed. W.H. Walton Permagon Press — In Press.
Yeates, D.B., Spektor, D.M., Leikauf, CD., and Pitt, B.R. (1981c). Effects of Drugs on Mucociliary Transport in the Trachea and Bronchial Airways. Chest — In Press.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Yeates, D.B. (1982). The Role of Mucociliary Transport in the Pathogenesis of Chronic Obstructive Pulmonary Disease. In: Chantler, E.N., Elder, J.B., Elstein, M. (eds) Mucus in Health and Disease—II. Advances in Experimental Medicine and Biology, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9254-9_63
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9254-9_63
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9256-3
Online ISBN: 978-1-4615-9254-9
eBook Packages: Springer Book Archive