Skip to main content
SpringerLink
Log in

Structure and Function of Mucus

  • Chapter
Mucus in Health and Disease—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 144))

Abstract

A rather far reaching assumption is implied in writing the above title. Is it indeed possible to treat “mucus” as a unique secretion whose properties in health and disease can be discussed in a single context, i.e. without reference to its origin, to its detailed function or to the kind of disease which may affect its proper action. Is mucus, even in principle, the same everywhere?

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R.A. Gibbons and G.P. Roberts, Some Aspects of the Structure of Macromolecular Constituents of Epithelial Mucus, Ann. N.Y. Acad. Sci. 106: 218–232 (1963).

    Article  PubMed  CAS  Google Scholar 

  2. J. Sadé, N. Eliezer, A. Silberberg, and A.C. Nevo, The Role of Mucus in the Transport by Cilia, Am. Rev. Resp. Dis. 102: 48–52 (1970).

    PubMed  Google Scholar 

  3. F.A. Meyer, N. Eliezer, A. Silberberg, J. Vered, N. Sharon, and J. Sadé, An Approach to the Biochemical Basis for the Transport Function of Epithelial Mucus, Bull. Physio-path. resp. 9: 250–272 (1973).

    Google Scholar 

  4. F.A. Meyer, Comparison of Structural Glycoproteins from Mucus of Different Sources, Biochim. Biophys. Acta. 493: 272–282 (1977).

    PubMed  CAS  Google Scholar 

  5. M. Lhermitte, G. Lamblin, J.J. Lafitte, J. Rousseau, P. Degand, and P. Roussel, Properties of human neutral bronchial mucins after modification of the peptide or the carbohydrate moieties, Biochimé, 58: 367–372 (1976).

    Article  CAS  Google Scholar 

  6. K.S.P. Bhushana Rao and P.L. Masson, Study of the Primary Structure of the Peptide Core of the Bovine Estrus Cervical Mucin, J. Biol. Chem. 252: 7788–7795 (1977).

    Google Scholar 

  7. M. Scawen and A. Allen, The Action of Proteolytic Enzymes on the Glycoprotein from Pig Gastric Mucin, Biochem. J. 163: 363–368 (1977).

    PubMed  CAS  Google Scholar 

  8. R.A. Gibbons, Mucus of the Mammalian Genital Tract, Brit. Med. Bull. 34: 34–38 (1978).

    PubMed  CAS  Google Scholar 

  9. C.F. Phelps, Biosynthesis of Mucus Glycoprotein. Brit. Med. Bull. 34: 43–48 (1978).

    PubMed  CAS  Google Scholar 

  10. R. Jones and L. Reid, Secretory Cells and their Glycoproteins in Health and Disease, Brit.Med.Bull. 34: 9–16 (1978).

    PubMed  CAS  Google Scholar 

  11. F.A. Meyer, Mucus Structure: Relation to Biological Transport Function, Biorheology 13: 49–58 (1976).

    PubMed  CAS  Google Scholar 

  12. F.A. Meyer and A. Silberberg, Structure and Function of Mucus, in “Respiratory Tract Mucus,” Ciba Foundation Symposium 54 (new series) Elsevier, Amsterdam (1978); pp.203–218.

    Google Scholar 

  13. A. Courts, The N–Terminal Amino Acid Residues of Gelation. 2. Thermal degradation, Biochem. J. 58: 77–79 (1954).

    Google Scholar 

  14. F.A. Meyer (to be published).

    Google Scholar 

  15. F.A. Meyer and A. Silberberg, The Rheology and Molecular Organization of Mucus, Biorheology 17: 163–168 (1980).

    PubMed  CAS  Google Scholar 

  16. M. King, A. Gilboa, F.A. Meyer and A. Silberberg, On the Transport of Mucus and its Rheological Simulants in Ciliated Systems, Am. Rev. Resp. Dis. 110: 740–745 (1974).

    PubMed  CAS  Google Scholar 

  17. R.A. Gelman and F.A. Meyer, Mucociliary Transference Rate and Mucus Viscoelasticity. Dependence on Dynamic Storage and Loss Modulus, Am. Rev. Resp. Dis. 120: 553–557 (1979).

    PubMed  CAS  Google Scholar 

  18. C.K. Shih, M. Litt, M.A. Khan and D.P. Wolf, Effect of Non-dialyzable Solids Concentration and Viscoelasticity on Ciliary Transport of Tracheal Mucus, Am. Rev. Resp. Dis. 115: 989–995 (1977).

    PubMed  CAS  Google Scholar 

  19. A.L. McCall, W.P. Potsic, C.K. Shih and M. Litt, Physico-chemical Properties of Human Middle Ear Effusions (Mucus) and their Relation to Ciliary Transport, The Larynscope 88: 729–738 (1978).

    CAS  Google Scholar 

  20. M. King, Interrelation between Mechanical Properties of Mucus and Mucociliary Transport: Effect of Pharmacologic Interactions, Biorheology 16: 57–68 (1979).

    PubMed  CAS  Google Scholar 

  21. F.A. Meyer, M. King and R.A. Gelman, On the Role of Sialic Acid in the Rheological Properties of Mucus, Biochim. Biophys. Acta. 392: 223–232 (1975).

    Article  PubMed  CAS  Google Scholar 

  22. W.C. Stewart, Weight-Carrying Capacity and Excitability of Excised Ciliated Epithelium, Amer. J. of Physiol. 152: 1–5 (1948).

    CAS  Google Scholar 

  23. J.D. Ferry, “Viscoelastic Properties of Polymers,” 2nd ed. Wiley, New York (1970); p.204.

    Google Scholar 

  24. T.L. Hill, “Introduction to Statistical Thermodynamics,” Addison-Wesley/Reading (1960); pp.410–414.

    Google Scholar 

  25. A. Gilboa and A. Silberberg, Characterization of Epithelial Mucus and its Function in Clearance by Ciliary Propulsion, in “Air Pollution and the Lung,” E.E. Aharonson, A. Ben-David, M.A. Klingberg (eds.), Wiley, New York (1975); pp.49–63.

    Google Scholar 

  26. T. van Vliet, N. Weiss and A. Silberberg (to be published).

    Google Scholar 

  27. F.A. Meyer, J. Vered and N. Sharon, Studies of Glycoproteins from Mucociliary Secretions, in. “Mucus in Health and Disease” M. Elstein and D.V. Parke (eds.), Plenum Press, New York (1977); pp. 239–249.

    Chapter  Google Scholar 

  28. A. Allen, Structure of Gastrointestinal Mucus Glycoproteins and the Viscous and Gel-Forming Properties of Mucus, Brit.Med.Bull. 34: 28–33 (1978).

    PubMed  CAS  Google Scholar 

  29. M.D.G. Oates, A.C. Rosbottom and J. Schrager, The Composition of Human Gastric Mucin, Mod. Probl. Paediat. 19: 11–21 (1977).

    CAS  Google Scholar 

  30. J.P. Pearson and A. Allen, A Protein, 70,000 Molecular Weight, is Joined by Disulphide Bridges to Pig Gastric Mucus Glycoproteins, Trans. Biochem. Sol. 8: 388–389 (1980).

    CAS  Google Scholar 

  31. G.P. Sachdev O.F. Fox, G. Wen, T. Schroeder, R.C. Elkins, and R. Carubelli, Isolation and Characterization of Glycoproteins from Canine Tracheal Mucus, Biochim. Biophys. Acta. 536: 184–196 (1978).

    PubMed  CAS  Google Scholar 

  32. J. Pearson, A. Allen and C. Venables, Gastric Mucus: Isolation and Polymeric Structure of the Undegraded Glycoprotein : Its Breakdown by Pepsin, Gastroenterology 78: 709–715 (1980).

    PubMed  CAS  Google Scholar 

  33. A. Allen, M. Mantle and J.P. Pearson, The Polymeric Structure of Mucus Glycoproteins, in “Glycoconjugates,” R. Schauer et al. (eds.), Georg Thieme, Stuttgart (1979); pp.42 –43.

    Google Scholar 

  34. T. Marshall and A. Allen, The Isolation and Characterization of the High-Molecular-Weight Glycoprotein from Pig Colonic Mucus, Biochem. J. 173: 569–578 (1978).

    PubMed  CAS  Google Scholar 

  35. D.M. Carlson, Chemistry and Biosynthesis of Mucin Glycoproteins, in “Mucus in Health and Disease,” M. Elstein and D.V. Parke (eds.), Plenum Press, New York (1977); pp.251–273.

    Chapter  Google Scholar 

  36. K.S.P. Bushana-Rao and P.L. Masson, A Tentative Model for the Structure of Bovine Oestrus Cervical Mucin, in “Mucus in Health and Disease,” M. Elstein and D.V. Parke (eds.), Plenum Press, New York (1977); pp. 275–282.

    Chapter  Google Scholar 

  37. J.F. Forstner, I. Jabbal, R. Qures, D.I.C. Kells, and G.G. Forstner, The Role of Disulphide Bonds in Human Intestinal Mucin, Biochem. J. 181: 725–732 (1979).

    PubMed  CAS  Google Scholar 

  38. G.P. Roberts, Structural Studies on the Glycoproteins from Bovine Cervical Mucus, Biochem.J. 173: 941–947 (1978).

    PubMed  CAS  Google Scholar 

  39. P.W. Kent, Chemical Aspects of Tracheal Glycoproteins, in “Respiratory Tract Mucus,” Ciba Foundation Symposium 54 (new series), Elsevier, Amsterdam (1978); pp. 155–174.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Polymer Research, Weizmann Institute of Science, Rehovot, 76100, Israel

    Alexander Silberberg & Frank A. Meyer

Authors
  1. Alexander Silberberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Frank A. Meyer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, University Hospital of South Manchester, Manchester, England

    Eric N. Chantler  & Max Elstein  & 

  2. University of Department of Surgery, Manchester Royal Infirmary, Manchester, England

    James B. Elder

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Silberberg, A., Meyer, F.A. (1982). Structure and Function of Mucus. In: Chantler, E.N., Elder, J.B., Elstein, M. (eds) Mucus in Health and Disease—II. Advances in Experimental Medicine and Biology, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9254-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9254-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9256-3

  • Online ISBN: 978-1-4615-9254-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation