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Macromolecular Composition of Secretions Produced by Human Bronchial Explants

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Mucus in Health and Disease—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 144))

Abstract

In recent years, the successful maintenance of explants of human1'2 and animal3 airway mucosa in organ culture has contributed to our understanding of factors which regulate the secretion of tracheo-bronchial mucus. Such in vitro preparations, particularly of human airways, also provide the possibility for assessing the effects of pharmacologic stimuli on both the composition of airway mucus and the structural characteristics of its macromolecular components. This report describes the preliminary findings of an analysis of the macromolecular components of secretions produced by human bronchial explants.

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References

  1. S. J. Coles and L. Reid, Inhibition of glycoconjugate secretion by colchicine and cytochalasin B. An in vitro study of human airway, Cell Tissue Res., 214: 107 (1981).

    Article  PubMed  CAS  Google Scholar 

  2. T. F. Boat and J. L. Kleinerman, Human respiratory tract secretions. Effect of cholinergic and adrenergic agents on in vitro release of protein and mucous glycoproteins, Chest, 67(Suppl.): 325 (1975).

    Article  Google Scholar 

  3. L. W. Chakrin, A. P. Baker, S. S. Spicer, J. R. Wardell, Jr., N. Desanctis and C. Dries, Synthesis of macromolecules by canine trachea, Am. Rev. Respir. Dis., 105: 368 (1973).

    Google Scholar 

  4. J. M. Creeth, K. R. Bhaskar, J. R. Horton, I. Das, M. T. Lopez-Vidriero and L. Reid, The separation and characterization of bronchial glycoproteins by density gradient methods, Biochem. J., 167: 557 (1977).

    PubMed  CAS  Google Scholar 

  5. P.O. Kwiterovich, H. R. Sloan and D. Fredrickson, Glycolipids and other lipid constituents of normal human liver, J. Lipid Res., 11: 322 (1970).

    PubMed  CAS  Google Scholar 

  6. J. R. Clamp, T. Bhatti and R. E. Chambers, The examination of carbohydrates in glycoproteins by gas-liquid chromatography, in: “Glycoproteins, Their Composition, Structure and Function, 2nd edition”, A. Gottschalk, ed., Elsevier, Amsterdam (1972).

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  7. K. R. Bhaskar, unpublished observation.

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Author information

Authors and Affiliations

  1. Department of Pathology Research, The Children’s Hospital Medical Center and Harvard Medical School, Boston, MA, 02115, USA

    Stephen J. Coles, K. R. Bhaskar, Donna Defeudis O’Sullivan & Lynne M. Reid

Authors
  1. Stephen J. Coles
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  2. K. R. Bhaskar
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  3. Donna Defeudis O’Sullivan
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  4. Lynne M. Reid
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, University Hospital of South Manchester, Manchester, England

    Eric N. Chantler  & Max Elstein  & 

  2. University of Department of Surgery, Manchester Royal Infirmary, Manchester, England

    James B. Elder

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© 1982 Plenum Press, New York

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Coles, S.J., Bhaskar, K.R., O’Sullivan, D.D., Reid, L.M. (1982). Macromolecular Composition of Secretions Produced by Human Bronchial Explants. In: Chantler, E.N., Elder, J.B., Elstein, M. (eds) Mucus in Health and Disease—II. Advances in Experimental Medicine and Biology, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9254-9_56

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  • DOI: https://doi.org/10.1007/978-1-4615-9254-9_56

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9256-3

  • Online ISBN: 978-1-4615-9254-9

  • eBook Packages: Springer Book Archive

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