Endocervical Changes in the Guinea Pig after Treatment With 11-ß - Oestradiol and 9,10 Dimethylbenzanthracene

  • John A. Thomas
  • Frederick D. Dallenbach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)


Revadi and Thomas (1979) have established the existence of normal cyclic variations in the human uterine endocervical mucosa. Their further studies (1980) on endogenously-produced oestrogen states and the human uterine endocervix showed that oestrogen produces a progressive increase in endocervical mucosal cell heights which is unrivalled by the endocervix, even in the pregnant state. On the basis of these studies, they hypothesized, that though oestrogen, was probably responsible for the secretion of excessive quantities of endocervical mucus, the release of this mucus was probably mediated by progesterone. In their studies basal cell proliferation was never seen.


Mucus Cell Squamous Metaplasia Uterine Horn Ground Substance Pregnant State 
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  1. Revadi, P.S. and Thomas, John A. 1979. Uterine endocervical morphology in different phases of the menstrual cycle. Indian J. Med. Res. 70, 49–54.PubMedGoogle Scholar
  2. Revadi, P.S. and Thomas, John A. 1980. Uterine endocervical Indian J. Med. Res. 71, 884–889.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • John A. Thomas
    • 1
  • Frederick D. Dallenbach
    • 2
  1. 1.Department of PathologySt John’s Medical CollegeBangaloreIndia
  2. 2.Institute of Experimental PathologyGerman Cancer Research CentreHeidelbergW. Germany

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