Abstract
In many epithelial glycoproteins a reciprocal relation exiStS between levels of L-fucose and sialic acid which could be the result of their mutually exclusive incorporation during oligosaccharide synthesis1. Changes in the visco-elastic properties of human cervical mucus occurring during the menstrual cycle may be related to alterations in the structure2 or composition3 of cervical mucin involving terminal L-fucosyl and sialyl residues. In the present study the possible role of endogenous glycosyltransferases in controlling levels of L-fucose and N-acetylneuraminic acid in cervical mucin was investigated by measuring the variation in activity of ß-galacto-side fucosyl and sialyltransferases in the cervical epithelium throughout the menstrual cycle.
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References
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P.R. Scudder and E.N. Chantler, Glycosyltransferases of the human cervical epithelium. I. Characterisation of a β-galactoside α-2-L-fucosyltransferase and the identification of a β-N-acetylglucosaminide α-3-L-fucosyltransferase, Biochim. Biophys. Acta (1981) in press.
P.R. Scudder and E.N. Chantler, Glycosyltransferases of the human cervical epithelium. II. Characterisation of a CMP-N-acetylneuraminic acid: glycoprotein sialyltransferase, Biochim. Biophys. Acta (1981) in press.
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© 1982 Plenum Press, New York
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Scudder, P.R., Chantler, E.N. (1982). Control of Human Cervical Mucin Glycosylation by Endogenous Fucosyl and Sialyltransferases. In: Chantler, E.N., Elder, J.B., Elstein, M. (eds) Mucus in Health and Disease—II. Advances in Experimental Medicine and Biology, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9254-9_40
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DOI: https://doi.org/10.1007/978-1-4615-9254-9_40
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