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Control of Human Cervical Mucin Glycosylation by Endogenous Fucosyl and Sialyltransferases

  • Peter R. Scudder
  • Eric N. Chantler
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)

Abstract

In many epithelial glycoproteins a reciprocal relation exiStS between levels of L-fucose and sialic acid which could be the result of their mutually exclusive incorporation during oligosaccharide synthesis1. Changes in the visco-elastic properties of human cervical mucus occurring during the menstrual cycle may be related to alterations in the structure2 or composition3 of cervical mucin involving terminal L-fucosyl and sialyl residues. In the present study the possible role of endogenous glycosyltransferases in controlling levels of L-fucose and N-acetylneuraminic acid in cervical mucin was investigated by measuring the variation in activity of ß-galacto-side fucosyl and sialyltransferases in the cervical epithelium throughout the menstrual cycle.

Keywords

Menstrual Cycle Luteal Phase Cervical Mucus Neuraminic Acid Cervical Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    T.A. Beyer, J.I. Rearick, J.C. Paulson, J-P. Prieels, J.E. Sadler and R.L. Hill, Biosynthesis of mammalian glycoproteins. Glycosylation pathways in the synthesis of the nonreducing terminal sequences, J. Biol. Chem. 254: 12531 (1979).PubMedGoogle Scholar
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    Nasir-Ud-Din, R.W. Jeanloz, V.N. Reinhold, J.W. McArthur, Changes in the glycoprotein structure of the cervical mucus of the bonnet monkey during the menstrual cycle. Study on the pre-menstrual phase mucus, Carbohydr. Res. 75: 349 (1979).PubMedCrossRefGoogle Scholar
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    E.N. Chantler and E. Debruyne, Factors regulating the changes in cervical mucus in different hormonal states, Adv. Exp. Med. Biol. 89: 131 (1976).Google Scholar
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    P.R. Scudder and E.N. Chantler, Glycosyltransferases of the human cervical epithelium. I. Characterisation of a β-galactoside α-2-L-fucosyltransferase and the identification of a β-N-acetylglucosaminide α-3-L-fucosyltransferase, Biochim. Biophys. Acta (1981) in press.Google Scholar
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    P.R. Scudder and E.N. Chantler, Glycosyltransferases of the human cervical epithelium. II. Characterisation of a CMP-N-acetylneuraminic acid: glycoprotein sialyltransferase, Biochim. Biophys. Acta (1981) in press.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Peter R. Scudder
    • 1
    • 2
  • Eric N. Chantler
    • 1
  1. 1.Department of Obstetrics & GynaecologyUniversity Hospital of South ManchesterManchesterUK
  2. 2.Division of Communicable DiseasesClinical Research Centre HarrowMiddlesexUK

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