Control of Human Cervical Mucin Glycosylation by Endogenous Fucosyl and Sialyltransferases
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In many epithelial glycoproteins a reciprocal relation exiStS between levels of L-fucose and sialic acid which could be the result of their mutually exclusive incorporation during oligosaccharide synthesis1. Changes in the visco-elastic properties of human cervical mucus occurring during the menstrual cycle may be related to alterations in the structure2 or composition3 of cervical mucin involving terminal L-fucosyl and sialyl residues. In the present study the possible role of endogenous glycosyltransferases in controlling levels of L-fucose and N-acetylneuraminic acid in cervical mucin was investigated by measuring the variation in activity of ß-galacto-side fucosyl and sialyltransferases in the cervical epithelium throughout the menstrual cycle.
KeywordsMenstrual Cycle Luteal Phase Cervical Mucus Neuraminic Acid Cervical Epithelium
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