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The Intestinal Mucus Barrier to Parasites and Bacteria

  • G. B. Lee
  • B. M. Ogilvie
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)

Abstract

The intestinal mucus layer has been recognised as a layer in which both antibodies are contained1 and microorganisms are trapped2,3,4. we have examined the interrelationship between these three (i.e. intestinal mucus layer, antibodies and microorganisms) using nematode parasite infections of the rat and the resident bacteria of the intestines of man.

Keywords

Mucus Layer Infective Larva Immune Serum Small Intestinal Mucosa Vibrio Cholerae 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    W.A. Walker, K.J. Isselbacher and K.J. Bloch. Immunologic control of soluble protein absorption from the small intestine — a gut-surface phenomenon. Am. J. Clin. Nutr. 27, 1434 (1974)PubMedGoogle Scholar
  2. 2.
    H.W. Florey. Mucin and the protection of the body. Proc. Roy. Soc. London. 143 (B) 147 (1955)Google Scholar
  3. 3.
    D.C. Savage, R. Dubos and R. Schaedler. The gastro intestinal epithelium and its autochthonous bacterial flora. J. Exp. Med. 127, 67 (1968).PubMedCrossRefGoogle Scholar
  4. 4.
    G.D. Schrank and W.F. Verwey. Distribution of cholera organisms in experimental Vibrio cholerae infections. Inf. & Imm. 13, 195 (1976).Google Scholar
  5. 5.
    A.G. Plaut et al. Studied of intestinal microflora. 111. The microbial flora of human small intestinal mucosa and fluids. Gastroenterology 53, 868 (1967).PubMedGoogle Scholar
  6. 6.
    H.R.P. Miller and Y. Nawa. Immune regulation of intestinal goblet cell differentiation. Nouv. Rev. Fr. Hematol, 21, 31 (1979).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. B. Lee
    • 1
    • 2
  • B. M. Ogilvie
    • 1
    • 2
  1. 1.Depts. of Immunology and GastroenterologyClinical Research CentreHarrowUK
  2. 2.Dept. of ParasitologyNational Institute for Medical ResearchLondonUK

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