Protection Against Nematodes by Intestinal Mucus

  • H. R. P. Miller
  • J. F. Huntley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)


Several lines of evidence suggest that intestinal mucus is involved in protection against nematode infections (Miller and Nawa, 1979). For example, Trichinella spiralis larvae become entrapped in mucus both in vivo in immune rats and in vitro (Lee and Ogilvie, 1980). Similarly, the immune expulsion of Njppostronqylus brasiliensis from rat intestine is accompanied by goblet cell hyperplasia and increased turnover of mucin (Miller et al., 1981). The experiments described here provide further information on the role of mucus in protection against N. brasiliensis.


Mucus Layer Nematode Infection Goblet Cell Hyperplasia Intestinal Mucus Intestinal Nematode 
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  1. Miller, H.R.P., and Nawa, Y., 1979, Immune regulation of goblet cell differentiation, specific induction of non specific protection against helminths? Nouv. Rev. Fr. Hematol., 21: 31PubMedGoogle Scholar
  2. Lee, G.B., and Ogilvie, B.M., 1980, The mucus layer in intestinal nematode infections, in: ‘Mucosal immune system in health and disease, report of 81st Conference on pediatric research’ Ogra, P.L. and Bienenstock, J., Ed., (in press).Google Scholar
  3. Miller, H.R.P., Huntley, J. F., and Dawson, A. McL., 1981, Mucus secretion in the gut, its relationship to the immune response in Nippostrongylus infected rats, in: ‘Current Topic in Veterinary Medicine and Animal Science’, Bourne, F. J., ed., Martinus and Nijhoff, London and The Hague (in press).Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • H. R. P. Miller
    • 1
  • J. F. Huntley
    • 1
  1. 1.Department of Pathology, Animal Diseases Research AssociationMoredun InstituteEdinburghUK

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