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Gastric Mucus Degradation In Vivo in Peptic Ulcer Patients and the Effects of Vagotomy

  • Fekry Younan
  • Jeffrey P. Pearson
  • Adrian Allen
  • Christopher W. Venables
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)

Abstract

Pepsin and other proteolytic enzymes solubilise mucus gel. Studies in vitro on human and pig gastric mucus have shown that this can be explained in molecular terms by the production of degraded glycoprotein subunits (molecular weight 5 × 105) which no longer retain the gel-forming properties of the native glycoprotein (molecular weight 2 × 106) (Scawen & Allen, 1977, Pearson et al., 1980). These studies imply that any increase in mucus glycoprotein in gastric juice could (Allen & Garner, 1980) reflect an increased peptic erosion of the surface gel and not increased mucus secretion as is often stated. We have investigated this possibility by examining the mucus glycoprotein present in gastric washouts following insulin (I.V. 0.2 u/Kg) stimulation in duodenal ulcer patients.

Keywords

Ulcer Patient Duodenal Ulcer Patient Gastric Mucus Peptic Ulcer Patient Mucus Glycoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature

  1. Allen, A. & Garner, A., 1980, Gastric mucus and bicarbonate secretion and their possible role in mucosal protection. Gut 21: 249–262.PubMedCrossRefGoogle Scholar
  2. Mantle, M. & Allen, A., 1978, A colorimetric assay for glycoproteins based on the periodic acid/Schif stain. Biochem. Soc. Trans., 6: 607–609.PubMedGoogle Scholar
  3. Pearson, J.P., Allen, A. & Venables, C.W., 1980, Gastric mucus: isolation and polymeric structure of the undegraded glycoprotein: its breakdown by pepsin. Gastroenterology 78: 709–715.PubMedGoogle Scholar
  4. Scawen, M. & Allen, A., 1977, The action of proteolytic enzymes on the glycoprotein from pig gastric mucus. Biochem. J. 163: 363–368.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Fekry Younan
    • 1
    • 2
  • Jeffrey P. Pearson
    • 2
  • Adrian Allen
    • 2
  • Christopher W. Venables
    • 1
    • 2
  1. 1.Department of Physiology and SurgeryThe UniversityNewcastle upon TyneUK
  2. 2.The UniversityNewcastle upon TyneUK

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