Gastric Mucus Degradation In Vivo in Peptic Ulcer Patients and the Effects of Vagotomy
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Pepsin and other proteolytic enzymes solubilise mucus gel. Studies in vitro on human and pig gastric mucus have shown that this can be explained in molecular terms by the production of degraded glycoprotein subunits (molecular weight 5 × 105) which no longer retain the gel-forming properties of the native glycoprotein (molecular weight 2 × 106) (Scawen & Allen, 1977, Pearson et al., 1980). These studies imply that any increase in mucus glycoprotein in gastric juice could (Allen & Garner, 1980) reflect an increased peptic erosion of the surface gel and not increased mucus secretion as is often stated. We have investigated this possibility by examining the mucus glycoprotein present in gastric washouts following insulin (I.V. 0.2 u/Kg) stimulation in duodenal ulcer patients.
KeywordsUlcer Patient Duodenal Ulcer Patient Gastric Mucus Peptic Ulcer Patient Mucus Glycoprotein
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