Advertisement

Ultrastructural Alterations in the Colonic Mucus Layer During Carcinogenesis : A Scanning Electron Microscopy Study

  • O. J. Traynor
  • C. B. Wood
  • N. Costa
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)

Abstract

The colonic mucus layer is considered to have several functions, including lubrication, waterproofing, and protection of the mucosal epithelium (Forstner, 1978). The precise extent of its protective role is not certain but it seems likely that mucus affords some protection against noxious agents in the bowel lumen, possibly including carcinogens. The functions of mucus are intimately related to its structure (Allen, 1977) and minor alterations in its chemical composition may impair its protective functions. Histochemical and biochemical alterations in colonic mucus in malignancy have previously been reported (Filipe, 1969; Culling et al, 1977; Filipe and Cooke, 1974) but the effect of these alterations on the structure and functions of mucus have not been described. This study was designed to examine changes in the physical appearance of the colonic mucus layer during carcinogenesis, using the high magnifications which can be attained by scanning electron microscopy.

Keywords

Sialic Acid Scan Electron Microscopy Study Colonic Polyp Mucus Layer Mucosal Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen, A., 1977, Adv. Exp. Med. Biol. 89: 283PubMedCrossRefGoogle Scholar
  2. Culling, C. F. A., Reid, P. E., Worth, A. J., and Dunn, W. L., 1977, J. Clin. Path. 30: 1056PubMedCrossRefGoogle Scholar
  3. Filipe, M. I., 1969, Gut 10: 577PubMedCrossRefGoogle Scholar
  4. Filipe, M. I., and Cooke, K. B., 1974, J. Clin. Path. 27: 315PubMedCrossRefGoogle Scholar
  5. Filipe, M. I., and Branfoot, A. C., 1974, Cancer 34: 282PubMedCrossRefGoogle Scholar
  6. Forstner, J. F., 1978, Digestion 17: 234PubMedCrossRefGoogle Scholar
  7. Gottschalk, A., 1960, Nature 186: 949PubMedCrossRefGoogle Scholar
  8. Litt, M., and Khan, M. A., 1976, Biorheology 13: 27Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • O. J. Traynor
    • 1
    • 2
  • C. B. Wood
    • 1
    • 2
  • N. Costa
    • 1
    • 2
  1. 1.Department of SurgeryRoyal Postgraduate Medical SchoolLondonUK
  2. 2.Life Sciences E M Unit, Department of BotanyImperial CollegeLondonUK

Personalised recommendations