Restriction of Hydrogen and Sodium Ion Diffusion in Porcine Gastric Mucin: A Concentration Dependent Phenomenon

  • Michael Lucas
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)


Gastric mucin has long been thought of as having a protective role against the high levels of acidity that the mucosa are often exposed to. With the advent of the concept of an ‘unstirred layer’ next to all membranes,mucin has been envisaged as providing a structural framework for maintaining and extending an external unstirred layer. Such an unstirred layer within the mucus is thought to reduce access to the mucosa by increasing the mean diffusion path length (1) and the possible ability of mucus to retard hydrogen ion access by restricting the free diffusion is often discounted (2) Since mucus is an exceptionally viscous substance,a restriction of the diffusion process might be expected,as predicted by the Stokes-Einstein equation (3).


Apparent Diffusion Coefficient Diffusion Chamber Transfer Rate Constant Unstirred Layer Gastric Mucus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    Allen, A. (1978) Br med Bull 34: 28–33PubMedGoogle Scholar
  2. 2).
    Carter, D.C.(1980) Scientific Foundation of Gastroenterology, Eds.Sircus,W. & Smith, A.N., William Heinemann, London. p344.Google Scholar
  3. 3).
    Einstein, A. (1905) Ann der Physik 17: 549–560CrossRefGoogle Scholar
  4. 4).
    Brown, B.M.(1961) The Mathematical Theory of Linear Systems John Wiley, New York. p7Google Scholar
  5. 5).
    Jacobs, M.H. (1935) Ergb Biol 12: 70–71Google Scholar
  6. 6).
    Robinson, R.A. & Stokes, R.H. (1965) Electrolyte Solutions. Butterworth, London, UK.Google Scholar
  7. 7).
    Williams, S.E. & Turnberg, L.A. (1980) Gastroenterol 79: 299–304Google Scholar
  8. 8).
    Allen, A. & Garner, A. (1980) Gut 21: 249–262PubMedCrossRefGoogle Scholar
  9. 9).
    Dietschy, J.M. et al., (1971) Gastroenterol 61: 932–934Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Michael Lucas
    • 1
  1. 1.Institute of PhysiologyUniversity of GlasgowGlasgowScotland UK

Personalised recommendations