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Studies of the pH Gradient Across the Mucus on Rat Gastric Mucosa in Vivo and Across Mucus on Human Gastric Mucosa In Vitro

  • I. N. Ross
  • H. M. M. Bahari
  • L. A. Turnberg
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)

Abstract

The gastric mucosal barrier to hydrogen ion back diffusion is thought to consist of the apical membrane of the surface epithelial cells and the tight junctions of adjacent cells. An alternative hypothesis is that gastric mucus acts as an unstirred layer allowing hydrogen ions diffusing from the lumen, to be neutralised by bicarbonate secreted from the surface epithelial cells (1). If this hypothesis is correct, it should be possible to demonstrate a pH gradient across the mucus layer. In this study the presence of such a mucus pH gradient was looked for in rat fundic mucosa, in vivo and the effects on this pH gradient of potential damaging agents such as aspirin and N-acetyl-l-cysteine (NAC) examined.

Keywords

Mucus Layer Surface Epithelial Cell Luminal Side Unstirred Layer Gastric Mucus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Heatley NG (1959) Mucosubstance as a barrier to diffusion. Gastroenterology, 37, 313–317.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • I. N. Ross
    • 1
  • H. M. M. Bahari
    • 1
  • L. A. Turnberg
    • 1
  1. 1.University Department of MedicineHope HospitalSalfordUK

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