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The Gastric “Mucus-Bicarbonate” Barrier: Effect of Luminal Acid on HCO3- Transport by Amphibian Fundic Mucosa In Vitro

  • Jon R. Heylings
  • Andrew Garner
  • Gunnar Flemström
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)

Abstract

Transport of HCO- 3 by surface epithelial cells has been demonstrated in amphibian isolated gastric mucosa (Flemstrom, 1977) and in mammalian stomach in vivo (Garner and Flemström, 1978). These studies together with work on surface mucus gel have led to the proposal that the two secretions provide a first line of defense against intraluminal H+ ions (Allen and Garner, 1980). Although the stimulatory pathways controlling acid secretion and HCO- 3 transport are different, titratable alkalinity of fluid perfusing the canine Heidenhain pouch increased following instillation of HC1 into the gastric remnant (Garner and Hurst, 1980). Thus regulation of gastric HCO- 3 output by intraluminal acid may involve a humoral mechanism. The present study was designed to investigate the effect of luminal acidification on alkaline secretion by the isolated mucosa.

Keywords

Gastric Remnant Surface Epithelial Cell Bicarbonate Secretion Fundic Mucosa Luminal Acidification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Allen, A., and Garner, A., 1980, Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection, Gut, 21: 249.PubMedCrossRefGoogle Scholar
  2. Flemström, G., 1977, Active alkalinization by amphibian gastric fundic mucosa in vitro, Am. J. Physiol., 233: E1.PubMedGoogle Scholar
  3. Garner, A., and Flemström, G., 1978, Gastric HCO 3 secretion in the guinea pig, Am. J. Physiol., 234: E535.PubMedGoogle Scholar
  4. Garner, A., and Hurst, B. C., 1980, Stimulation of bicarbonate secretion i n the Heidenhain pouch dog by exogenous acid, Proc. Int. Union Physiol. Sci., 14: 427.Google Scholar
  5. Williams, S. E., and Turnberg, L. A., 1981, The demonstration of a pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a “mucus-bicarbonate” barrier, Gut, 22: in press.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jon R. Heylings
    • 1
  • Andrew Garner
    • 1
  • Gunnar Flemström
    • 1
  1. 1.I.C.I. Research LaboratoriesMacclesfieldUK

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