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Mucus in Health and Disease—II pp 183–185Cite as

The Gastric “Mucus-Bicarbonate” Barrier: Effect of Luminal Acid on HCO -3 Transport by Amphibian Fundic Mucosa In Vitro

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 144))

Abstract

Transport of HCO- 3 by surface epithelial cells has been demonstrated in amphibian isolated gastric mucosa (Flemstrom, 1977) and in mammalian stomach in vivo (Garner and Flemström, 1978). These studies together with work on surface mucus gel have led to the proposal that the two secretions provide a first line of defense against intraluminal H+ ions (Allen and Garner, 1980). Although the stimulatory pathways controlling acid secretion and HCO- 3 transport are different, titratable alkalinity of fluid perfusing the canine Heidenhain pouch increased following instillation of HC1 into the gastric remnant (Garner and Hurst, 1980). Thus regulation of gastric HCO- 3 output by intraluminal acid may involve a humoral mechanism. The present study was designed to investigate the effect of luminal acidification on alkaline secretion by the isolated mucosa.

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References

  • Allen, A., and Garner, A., 1980, Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection, Gut, 21: 249.

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  • Flemström, G., 1977, Active alkalinization by amphibian gastric fundic mucosa in vitro, Am. J. Physiol., 233: E1.

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  • Garner, A., and Flemström, G., 1978, Gastric HCO− 3 secretion in the guinea pig, Am. J. Physiol., 234: E535.

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  • Garner, A., and Hurst, B. C., 1980, Stimulation of bicarbonate secretion i n the Heidenhain pouch dog by exogenous acid, Proc. Int. Union Physiol. Sci., 14: 427.

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  • Williams, S. E., and Turnberg, L. A., 1981, The demonstration of a pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a “mucus-bicarbonate” barrier, Gut, 22: in press.

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Author information

Authors and Affiliations

  1. I.C.I. Research Laboratories, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK

    Jon R. Heylings, Andrew Garner & Gunnar Flemström

Authors
  1. Jon R. Heylings
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  2. Andrew Garner
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  3. Gunnar Flemström
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, University Hospital of South Manchester, Manchester, England

    Eric N. Chantler  & Max Elstein  & 

  2. University of Department of Surgery, Manchester Royal Infirmary, Manchester, England

    James B. Elder

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© 1982 Plenum Press, New York

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Heylings, J.R., Garner, A., Flemström, G. (1982). The Gastric “Mucus-Bicarbonate” Barrier: Effect of Luminal Acid on HCO -3 Transport by Amphibian Fundic Mucosa In Vitro. In: Chantler, E.N., Elder, J.B., Elstein, M. (eds) Mucus in Health and Disease—II. Advances in Experimental Medicine and Biology, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9254-9_27

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  • DOI: https://doi.org/10.1007/978-1-4615-9254-9_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9256-3

  • Online ISBN: 978-1-4615-9254-9

  • eBook Packages: Springer Book Archive

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