Effect of Lysolecithin on the Constituents of Gastric Mucus

  • Bronislaw L. Slomiany
  • George B. Jerzy Glass
  • Koichi Kojima
  • Zofia Banas-Gruszka
  • Amilia Slomiany
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)


The surface epithelium of gastric mucosa is covered by an extracellular and renewable layer of a viscous mucus gel. This, together with an intracellular apical layer of mucus has been referred to by Hollander (1954) as “two layer mucous barrier”. Yet its ability to protect the underlying mucosa from the physical and enzymatic injury has been questioned by Heatley (1959), and later protective function has been rather assigned to the so-called “mucosal barrier”. This Is supposed to consist of the plasma membranes and the intracellular and basal membranes, as well as junctions of the epithelium (Davenport, 1970). Only more recently, when the retardation of acid and pepsin diffusion by mucus gel has been demonstrated by newer technics (Allen, 1976; Pearson et al, 1980; Williams and Turnberg, 1980) the potential role of the mucus in mucosal protection became plausible again. It has been also realized that the solubilization, depolymerization and depletion of the mucus may be contributory to the breaking of the “mucosal barrier” by anti-inflammatory agents, such as aspirin, indomethacin, phenylbutazone, steroids, etc. or other agents, such as stress, bile acids or et llanol (Stremple et al, 1973; Glass and Slomiany, 1977; Glass et al, 1979).


Gastric Mucosa Mucous Layer Mucosal Barrier Silicic Acid Column Gastric Erosion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Bronislaw L. Slomiany
    • 1
  • George B. Jerzy Glass
    • 1
  • Koichi Kojima
    • 1
  • Zofia Banas-Gruszka
    • 1
  • Amilia Slomiany
    • 1
  1. 1.Gastroenterology Research Laboratory, New York Medical College, Research CenterMetropolitan HospitalNew YorkUSA

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