Gastric Mucosubstances and Benign Gastric Ulceration

  • Shelagh M. Morrissey
  • J. G. Mehta
  • D. Hollanders
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)


Variations in the composition of mucosubstances have been demonstrated in the gastric contents of patients with chronic gastritis, pernicious anaemia and gastric carcinoma. There have however been few histochemical studies of the epithelial mucins observed in the benign gastric ulcers1. Neutral mucosubstances have been identified by their reaction with periodic acid-Schiff’s reagent to form magenta chromophores2. Haynes and Hartridge3 and Steedman4 have shown acidic mucosubstances to interact with Alcian Blue at different levels of pH to form blue chromophores. The method employed in this study is based on electronic densitometric measurements of chromophores. The energy absorbed by each chromophore is dependent upon two factors, the spectral characteristics of the chromophores and the concentration of the stained material.


Gastric Ulcer Alcian Blue Pernicious Anaemia Epithelial Mucin Antral Biopsy 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Shelagh M. Morrissey
    • 1
  • J. G. Mehta
    • 1
  • D. Hollanders
    • 1
    • 2
  1. 1.Department of Physiology, Queen Elizabeth CollegeUniversity of LondonLondonUK
  2. 2.Department of MedicineWithington HospitalManchesterUK

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