Antigenicities of Mucins - Their Relevance to Tumour Associated and Stage Specific Embryonic Antigens

  • Ten Feizi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 144)


Because of their relative abundance compared with membrane associated glycocon jugates of cells, secreted glycoproteins (mucins) have been the major source of oligosaccharides for defining the chemical nature of the blood group A, B, H, Lewisa and Lewisb antigens (reviewed in refs 1 and 2). It is now known that blood group antigenic determinants expressed on membrane-associated glycosphingolipids are the same as those on mucins (3). The patterns of antigen expression on these two categories of macromolecule are determined by the same blood group genes although their presence on secreted glycoproteins may in addition, be subject to the action of regulator genes such as the secretor gene (1).


Blood Group Antigenic Determinant Cold Agglutinin Secrete Glycoprotein Precursor Chain 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Ten Feizi
    • 1
  1. 1.Applied Immunochemistry Research Group, Division of Communicable DiseasesClinical Research CentreHarrowEngland

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