Antigenicities of Mucins - Their Relevance to Tumour Associated and Stage Specific Embryonic Antigens
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Because of their relative abundance compared with membrane associated glycocon jugates of cells, secreted glycoproteins (mucins) have been the major source of oligosaccharides for defining the chemical nature of the blood group A, B, H, Lewisa and Lewisb antigens (reviewed in refs 1 and 2). It is now known that blood group antigenic determinants expressed on membrane-associated glycosphingolipids are the same as those on mucins (3). The patterns of antigen expression on these two categories of macromolecule are determined by the same blood group genes although their presence on secreted glycoproteins may in addition, be subject to the action of regulator genes such as the secretor gene (1).
KeywordsBlood Group Antigenic Determinant Cold Agglutinin Secrete Glycoprotein Precursor Chain
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- 1.W. M. Watkins, Biochemistry and genetics of the ABO, Lewis and P blood group systems, in “Advances in Human Genetics”, H. Harris, K. Hirschhorn, eds. Vol.10. Plenum Publishing Co. pp 1 and 379 (1980).Google Scholar
- 2.E. A. K. Kabat, The carbohydrate moiety of the water-soluble human A, B, H, Lea and Leb substances, in: “Blood and Tissue Antigens” p 187. Academic Press, New York (1970).Google Scholar
- 3.S. -I. Hakomori, A. Kobata, Blood Group Antigens. In The Antigens. M. Sela, ed Academic Press, New York. Vol. II; p 79 (1974)Google Scholar
- 4.T. Feizi, E. A. Kabat, G. Vicari, B. Anderson and W. L. Marsh. Immunochemical studies on blood groups XLIX. The I antigen complex : specificity differences among anti-I sera revealed by quantitative precipitin studies; partial structure of the I determinant specific for one anti-I serum. J. Immunol. 106: 1578 (1971).PubMedGoogle Scholar
- 9.J. Picard, D. Waldron-Edward and T. Feizi, Changes in the expression of the blood group A,B,H, Lea and Leb antigens and the blood group precursor associated I (Ma) antigen in glycoprotein-rich extracts of gastric carcinomas. J. Clin. & Lab. Immunol. 1: 119 (1978).Google Scholar
- 10.T. Feizi, J. Picard, A. Kapadia and G. Slavin. Changes in the expression of the major blood group antigens ABH and their precursor antigens Ii in human gastri cancer tissues. In: Protides of Biological Fluids 27th Colloquium. Ed. H. Peeters Pergamon Press Oxford and New York. pp. 221. (1979).Google Scholar
- 11.A. Kapadia, T. Feizi, D. Jewell, J. Keeling, and G. Slavin. Immunocytochemical studies of blood group A,H,I and i antigens in gastric mucosae of infants with normal gastric histology and of patients with gastric carcinoma and chronic benign peptic ulceration. J. Clin Pathol. 34, 320 (1981).PubMedCrossRefGoogle Scholar
- 13.T. Feizi, A. Kapadia, and H.C. Gooi. Human monoclonal autoantibodies detect changes in expression and polarization of the Ii antigens during cell differentiation in early mouse embryos and teratocarcinomas. In: Teratocarcinoma and Cell Surface. Eds. Muramatsu, T. and Ikawa, Y. (Japan Scientific Socities Press.) In press.Google Scholar
- 14.T. Feizi. Structural and biological aspects of blood group I and i antigens on glycolipids and glycoproteins. Blood Transfusion and Immunohaematology, 23: 563. (1980).Google Scholar
- 15.H. C. Gooi, T. Feizi, A. Kapadia, B. B. Solter, D. and M.J. Evans. Stage specific embryonic antigen (SSEA-1) involves 3-fucosylated Type 2 precursor chain. Nature. In press.Google Scholar
- 17.N. Fox, I. Damjanov, and A. Martinez-Hernandez. Immuno-histochemical localization of the early embryonic antigen (SSEA-1) in postimplantation mouse embryos, and fetal and adult tissues. Develop. Biol. In press.Google Scholar