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Measurements of Ion Activity in the CNS: Extracellular K+ and Ca2+ in the Hippocampus

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Ion-Selective Microelectrodes and Their Use in Excitable Tissues

Abstract

The highly stratified organization and well documented electro-physiology of the hippocampus (Green, 1964; Pribram and Isaacson, 1975), as well as the availability of techniques for localized measurements with ion-sensitive microelectrodes (Walker, 1971; Oeme et al., 1976), have encouraged recent studies (Benninger et al., 1980; Krnjević et al., 1980) of transmembrane ionic shifts which may be associated with the generation of consciousness and memory formation, and a marked susceptibility to seizure activation and anoxic damage.

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References

  • Ben-Ari, Y., Krnjević, K., and Reinhardt, W., 1979, Hippocampal seizures and failure of inhibition, Can. J. Physiol. Pharmaco., 57:1462.

    Article  CAS  Google Scholar 

  • Benninger, C., Kadis, J., and Prince D.A., 1980, Extracellular calcium and potassium changes in hippocampal slices, Brain Res., 187:165.

    Article  PubMed  CAS  Google Scholar 

  • Green, J.D., 1964, The Hippocampus, Physiol. Re., 44:561.

    CAS  Google Scholar 

  • Krnjević, K., Morris, M.E., and Reiffenstein, R.J., 1980, Changes in extracellular Ca2+ and K+ activity accompanying hippocampal discharges, Can. J. Physiol. Pharmacol., 58:579.

    Article  PubMed  Google Scholar 

  • Lux, H.D., 1974, Fast recording ion specific microelectrodes: their use in pharmacological studies in the CNS, Neuropharmaco., 13:509.

    Article  CAS  Google Scholar 

  • MacVicar, B.A., Dudek, F.E., 1980, Dye-coupling between CA3 pyramidal cells in slices of rat hippocampus, Brain Res., 196: in press.

    Google Scholar 

  • Nicholson, C., ten Bruggencate, G., Stöckle, H., and Steinberg, R., 1978, Calcium and potassium changes in extracellular microenvironment of cat cerebellar cortex, J. Neurophysio., 41:1026.

    CAS  Google Scholar 

  • Oehme, M., Kessler, M., and Simon W., 1976, Neutral carrier Ca2+ microelectrode, Chimi., 30:204.

    CAS  Google Scholar 

  • Oehme, M., and Simon, W., 1976, Microelectrode for potassium ions based on a neutral carrier and comparison of its characteristics with a cation exchanger sensor, Anal. Chim. Act., 86:21.

    Article  CAS  Google Scholar 

  • Pribram, K.H., and Isaacson, R.L., eds.,1975,“Hippocampus: Structure and Development, Physiology and Behaviour”, Vols. 1 and 2, Plenum Press, New York.

    Google Scholar 

  • Reiffenstein, R.J., Krnjević, K., and Morris, M.E., 1980, Cyclic fluctuations in hippocampal firing and extracellular electrolytes during repetitive fimbrial stimulation, Proc. Can. Fe. Biol. So., 23:154.

    Google Scholar 

  • Rose, B., and Loewenstein, W.R., 1975, Permeability of cell junction depends on local cytoplasmic calcium activity, Natur., 254:250

    Article  CAS  Google Scholar 

  • Schwartzkroin, A., and Slawsky, M., 1977, Probable calcium spikes in hippocampal neurons, Brain Res., 135:157.

    Article  PubMed  CAS  Google Scholar 

  • Somjen, G.G., 1979, Extracellular potassium in the mammalian central nervous system, Ann. Rev. Physiol., 41:159.

    Article  CAS  Google Scholar 

  • Walker, J.L., 1971, Ion specific liquid ion exchanger microelectrodes, Anal. Chem., 43:89A.

    Article  Google Scholar 

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© 1981 Plenum Press, New York

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Morris, M.E. (1981). Measurements of Ion Activity in the CNS: Extracellular K+ and Ca2+ in the Hippocampus. In: Syková, E., Hník, P., Vyklický, L. (eds) Ion-Selective Microelectrodes and Their Use in Excitable Tissues. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9224-2_26

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  • DOI: https://doi.org/10.1007/978-1-4615-9224-2_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9226-6

  • Online ISBN: 978-1-4615-9224-2

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