Abstract
In the mammalian central nervous system extracellular free Ca2+ (aca) varies under a variety of conditions such as during repetitive electrical stimulation and seizures (Nicholson et al., 1977; Heinemann et al., 1977,1978). In order to gain insight into the mechanisms which are responsible for extracellular Ca2+ activity changes in cat neocortex, we measured aca changes with Ca2+ sensitive reference electrodes (Oehme et al., 1976) during iontophoretic application of excitatory and inhibitory amino acids and during repetitive electrical stimulation of the cortical surface and the thalamic ventrobasal complex. The effects of Ca2+ antagonists such as Co2+, Mn2+ and La3+ and of the sodium channel blocker tetrodotoxin (TTX) on changes in aca were also investigated.
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© 1981 Plenum Press, New York
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Heinemann, U., Pumain, R. (1981). Changes in Extracellular Free Ca2+ in the Sensorimotor Cortex of Cats During Electrical Stimulation and Iontophoretic Application of Amino-Acids. In: Syková, E., Hník, P., Vyklický, L. (eds) Ion-Selective Microelectrodes and Their Use in Excitable Tissues. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9224-2_25
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DOI: https://doi.org/10.1007/978-1-4615-9224-2_25
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