Skip to main content
SpringerLink
Log in
Book cover

Diet and Resistance to Disease pp 43–62Cite as

Anti-Inflammatory, Immunologic and Carcinostatic Attributes of Selenium in Experimental Animals

  • Chapter

Abstract

In the author’s opinion there are three major historical benchmarks in the evolution of our knowledge about the element of the moon, selenium (Se), since its discovery by Berzelius in 1817 (Fredga, 1972). The first significant chronological event was the recognition of Se as an integral part of factor 3 (Schwarz, 1951) which prevented dietary liver necrosis in rats fed selenium deficient torula yeast diets (Schwarz and Foltz, 1957). Occurring in 1957 this discovery subsequently led to the recognition of many selenium deficiency conditions in numerous animal species. Such Se deficiency conditions include exudative diathesis in poultry, while muscle disease in calves and lambs, and cardiac necrosis in mice and mink as well as others (Schwarz and Pathak, 1975).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References Cited

  • Abdullaev, G.B. Gasanov, G.G., Mekhitiew, A.T. Dzhafarov, A.I., Teplyokava, G. V., Perelygin, V. V. and Akhimedli, K. M. (1976) Antineoplastic activity of selenium compounds. Proc. Selenium in Biology, Nauchn. Konf. S. Gosanov, Ed., Elm, Baker, USSR, pp. 126–128, 182–192 Se-Te Abstract #34588.

    Google Scholar 

  • Abdullaev, G. B., Gasonov, G. G., Ragimov, R. N., Teplyakova, G. V., Mekhitiew, M. A. and Dzafarov, A. I. (1973) Antineoplastic activity of selenium compounds. Dokl, Akad. Nauk. Az. SSR, 29: 18–22.

    CAS  Google Scholar 

  • Aleksondrovicz, J. (1977) Effects of food enrichment with various doses of sodium selenite on some immune responses in laboratory animals. Rocz. Nauk. Zootech. 4: 113–126. Se-Te Abstracts #50098.

    Google Scholar 

  • Aleksondrovicz, J., Wazewska-Czyzewska, M., Bodzon, A., Dolezol, M., Dubis, K. (1977) Effects of food enrichment with various doses of sodium selenite on some immune responses in laboratory animals. Rocz. Nauk. Zootech. 4: 113–126. Se-Te Abstract #50098.

    Google Scholar 

  • Anonymous (1979a) Selenium in the Heart of China. The Lancet, October 1979 pp. 889–890.

    Google Scholar 

  • Anonymous (1979b) Observations on effect of sodium selenite in prevention of Keshan disease. Keshan Disease Research Group of the Chinese Academy of Medical Sciences Chinese Med. J. 92: 471–476.

    Google Scholar 

  • Baumgartner, W. A., Hill, V. A. and Wright, E. T. (1978) Antioxidant effects in the development of Ehrlich Ascites Carcinoma. Am. J. Clin. Nut. 31: 457–465.

    CAS  Google Scholar 

  • Berenshtein, T. F. (1972) Effect of selenium and Vitamin E on antibody formation in rabbits. Zdrawookhr Boloruss. 18: 34–41. Se-Te Abstracts #23317.

    CAS  Google Scholar 

  • Berenshtein, T. F. (1973) Stimulation of a nonspecific immunity in immunized rabbits by sodium selenite. Ser. Biyal Navek 1: 87–89. Se-Te Abstracts #27389.

    Google Scholar 

  • Berenshtein, T. F. (1975) Change in the immunological response of of vaccinated rabbits following the administration of selenium and Vitamin A. Selen. Biol., Mater. Nauchen. Konf., 2nd. 1: 94–96.

    Google Scholar 

  • Berenshtein, T. F., Zdravoukhi, C. G. (1976) Stimulation of the activity of nonspecific immunity factors by biological bases of molybdenum and selenium. Belowes 3: 67–68.

    Google Scholar 

  • Boyne, R. and Arthur, J. R. (1979) Alterations of neutrophil functions in selenium deficient cattle. J. Comp. Path. 89: 151–158.

    Article  CAS  Google Scholar 

  • Chen, J. R. and Anderson, J. M. (1979) Legionnaires’ disease: concentrations of selenium and other elements. Science 206: 1426–1427.

    Article  CAS  Google Scholar 

  • Clayton, C. E. and Baumann, C. A. (1949) Diet and Azo-dye tumors: effect of diet during a period when the dye is not fed. Cancer Res. 9: 575–582.

    CAS  Google Scholar 

  • Currie, G. A. and Eccles, S. A. (1976) Serum lysozyme as a marker of host resistance. Br. J. Cancer 33: 51–59.

    Article  CAS  Google Scholar 

  • Dalbert, P. (1912) Tentatives de traitement des Cancers par selenium. Bull. Assoc. France. Etude Cancer 5: 121–125

    Google Scholar 

  • Fredga, A. (1972) Organic selenium chemistry, in: “Annals of the New York Academy of Sciences” 192: 1–9.

    Article  CAS  Google Scholar 

  • Frost, D. V. (1975) Is selenium depletion the answer to the “arsenic cancer” mystery? Feedstuffs 47: April.

    Google Scholar 

  • Koller, L. D., Issacson-Kerkvliet, N., Exon, J. H., Brauner, J. A., and Patton, N. M. (1979) Synergism of methylmercury and selenium producing enhanced antibody formation in mice. Arch. Environ. Health 34: 248–51.

    CAS  Google Scholar 

  • Jacobs, M. M. and Griffin, A. C. (1977) Inhibitory effect of selenium of 1,2-dimethylhydrazine and methylazomethanol acetate induction of colon tumors. Cancer Let. 2: 133–138.

    Article  CAS  Google Scholar 

  • Levitt Research Laboratories, Inc. (1979) Antiinflammatory compositions containing selenium compounds. Chem. Abs. 91, //96638s.

    Google Scholar 

  • Martin, J. L. and Spallholz, J. E. (1977) Selenium in the immune response, in: “Proc. Symp. on Se-Te in the Environ.”, Industrial Health Foundation, Pittsburg, PA. pp. 204–225.

    Google Scholar 

  • Norman, B. B. and Johnson, W. (1976) Selenium responsive disease. Animal Nutritional and Health 31: 6.

    Google Scholar 

  • Novelli, R. and Spallholz, J. E. (1980) Incorporation of 75Se-selenite into peritoneal exudate cells of mice: separation and glutathione peroxidase assay of adherent and non-adherent cells, in: Selenium in Biology and Medicine, Second International Symposium, May 13–16, 1980, AVI Publisher, West Port, CONN, (in press).

    Google Scholar 

  • Osserman, E. F. and Lawlor, D. P. (1966) Serum and urinary lysozyme (neuraminidase) in monocyctic and monomyelocytic leukemia. J. Exp. Med. 124: 921–929.

    Article  CAS  Google Scholar 

  • Paynter, D. I. (1979) Glutathione peroxidase and selenium in sheep. I. Effect of intraruminal selenium pellets on tissue glutathione peroxidase activities. Aust. J. Agri. Res. 30: 695–702.

    Article  CAS  Google Scholar 

  • Poirier, K. A. and Milner, J. A. (1979) The effect of various seleno-compounds on Ehrlich Ascites tumor cells. Biol. Trace Element Res. 1: 25–34.

    Article  CAS  Google Scholar 

  • Roberts, M. E. (1963a) Antiinflammation studies I. antiinflammatory properties of liver fractions. Toxicol and Appl. Pharm. 5: 485–499.

    Article  CAS  Google Scholar 

  • Roberts, M. E. (1963b) Antiinflammation studies II. antiinflammatory properties of selenium. Toxicol and Appl. Pharm. 5: 500–506.

    Article  CAS  Google Scholar 

  • Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G. and Hoekstra, W. G. (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179: 588–590.

    Article  CAS  Google Scholar 

  • Saveleva, O. P., Markochev, A. B., Fadecv, N. D., Gubareva, A. V. and Andreev, E. P. (1979) Study of the tropism of some radiopharmacologic preparations in mice lymphogranulomatosis. Vopr. Orkol, 25: 104–107. Se-Te Abstracts #50474.

    CAS  Google Scholar 

  • Schrauzer, G. N., White, D. A. and Schneider, C. J. (1978) Selenium and cancer. Effects of selenium and of the diet on the genesis of spontaneous mammary tumors in virgin inbred female C3H/ST mice. Bioinorg. Chem. 8: 387–396.

    Article  CAS  Google Scholar 

  • Schrauzer, G. N. (1979) Trace elements in carcinogenesis, in: “Advances in Nutritional Research Volume Two” Ed. H. H. Drapes. Plenum Publishing Corp., N.Y.C. pp. 219–244.

    Google Scholar 

  • Schwarz, K. (1951) A hitherto unrecognized factor against dietary necrotic liver degeneration in American yeast (Factor 3). Proc. Soc. Exp. Biol. Med. 78: 852–856.

    CAS  Google Scholar 

  • Schwarz, K. and Foltz, C. M. (1957) Selenium as an integral part of Factor 3 against dietary necrotic liver degeneration. J. Am. Chem. Soc. 79: 3292–3293.

    Article  CAS  Google Scholar 

  • Schwarz, K. and Pathak, K. (1975) The biological essentiality of selenium and the development of biologically active organoselenium compounds of minimum toxicity. Chemica Scripta 8A: 85–95.

    CAS  Google Scholar 

  • Serfass, R. E. and Ganther, H. E. (1975) Defective microbicidal activity in glutathione peroxidase deficient neutrophils of selenium-deficient rats. Nature 255: 640.

    Article  CAS  Google Scholar 

  • Serfass, R. E. and Ganther, H. E. (1976) Effects of dietary selenium and tocopherol on glutathione peroxidase and superoxide dismutase activities in rat phagocytes. Life Sciences 19: 1139–1144.

    Article  CAS  Google Scholar 

  • Shackelford, J. and Martin, J. (1980) Antibody response of mature male mice after drinking water supplemented with selenium. Fed. Proc. 39: 339.

    Google Scholar 

  • Shamberger, R. J. (1970) Relationship of selenium to cancer. I. Inhibitory effect of selenium in carcinogenesis. J. Natl. Cancer Inst. 44: 931–936.

    CAS  Google Scholar 

  • Shamberger, R. J. and Rudolph, G. (1966) Protection against cocarcinogenesis by antioxidants. Experientia 22: 116–122.

    Article  CAS  Google Scholar 

  • Shamberger, R. J. and Willis, C. E. (1971) Selenium distribution and human cancer mortality. Crit. Rev. Clin. Lab. Sci. 2: 211–221.

    Article  CAS  Google Scholar 

  • Sheffy, B. E. and Schultz, R. D. (1978) Influence of Vitamin E and selenium on immune response mechanisms. Cornell Vet. 68 Suppl. 7: 89–93.

    Google Scholar 

  • Spallholz, J. E., Heinzerling, R. H., Gerlach, M. L. and Martin, J. L. (1974) The effect of selenite, tocopherol acetate and selenite, tocopherol acetate on the primary and secondary immune responses of mice administered tetanus toxoid or sheep red blood cell antigen. Fed. Proc. Abs. 33: 694.

    Google Scholar 

  • Spallholz, J. E., Martin, J. L., Gerlach, M. L. and Heinzerling, R. H. (1973a) Immunological responses of mice fed diets supplemented with selenite selenium. Proc. Soc. Exp. Bio. Med. 143: 685–689.

    CAS  Google Scholar 

  • Spallholz, J. E., Martin, J. L., Gerlach, M. L. and Heinzerling, R. H. (1973b) Enhanced IgM and IgG titers in mice fed selenium. Infec. Immunity 8: 841–842.

    CAS  Google Scholar 

  • Spallholz, J. E., Martin, J. L., Gerlach, M. L. and Heinzerling, R. H. (1975) Injectable selenium: Effect on the primary immune response of mice. Proc. Soc. Exp. Biol. Med. 148: 37–40.

    CAS  Google Scholar 

  • Tengerdy, R. P., Heinzerling, R. H. and Nockels, C. F. (1972) The effect of Vitamin E on the immune response of hypoxia and normal chickens. Infect. Immunity 5: 987–990.

    CAS  Google Scholar 

  • Tengerdy, R. P., Mathias, M. M., and Nockels, C. F. (1980) Vitamin E immunity and disease resistance, in: “Diet and Resistance to Disease” ed. Phillips and Baetz, Plenum, N.Y. pp. 27–42.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Food and Nutrition, Texas Tech University, Lubbock, Texas, 79409, USA

    Julian E. Spallholz

Authors
  1. Julian E. Spallholz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. U.S. Department of Agriculture Science and Education Administration—Agricultural Research, National Animal Disease Center, Ames, Iowa, 50010, USA

    Marshall Phillips  & Albert Baetz  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Press, New York

About this chapter

Cite this chapter

Spallholz, J.E. (1981). Anti-Inflammatory, Immunologic and Carcinostatic Attributes of Selenium in Experimental Animals. In: Phillips, M., Baetz, A. (eds) Diet and Resistance to Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9200-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9200-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9202-0

  • Online ISBN: 978-1-4615-9200-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation