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Experimental Animal Studies in Colonic Carcinogenesis and Dietary Fiber

  • Chapter
Book cover Medical Aspects of Dietary Fiber

Part of the book series: Topics in Gastroenterology ((TGEN))

Abstract

In many highly industrialized nations, colorectal cancer is the most commonly diagnosed internal malignancy when male and female rates of occurrence are combined.1–3 In Canada and the United States, in particular, it has emerged as a major cause of cancer mortality and a leading cause of significant morbidity among all types of malignancy.1,2 In 1977, over 100,000 individuals were diagnosed with large-bowel cancer in the United States alone, and about 50,000 persons died with this malignancy.1 Clearly colon cancer is one of the most serious problems facing our society. Unfortunately, even fundamental mechanisms involved in its etiology, pathogenesis, natural history, and spread of metastases are not well understood.

This work was supported by the Medical Research Council of Canada, the National Cancer Institute of Canada, the British Columbia Research Foundation, and the Vancouver Shane Foundation.

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References

  1. American Cancer Society. Cancer Statistics. Ca 27: 26, 1977.

    Google Scholar 

  2. Schottenfeld, D., and J. F. Haas. Epidemiology of colorectal cancer. In: Gastrointestinal Tract Cancer, M. Lipkin and R. A. Good (eds.). New York, Plenum Press, 1978, p. 207.

    Google Scholar 

  3. Doll, R., C. S. Muir, and J. Waterhouse. Caner Incidence in Five Continents (U.I.C.C.). Berlin, Springer-Verlag, 1970.

    Google Scholar 

  4. Moertel, C. G. Chemotherapy of gastrointestinal cancer. N. Engl. J. Med. 299: 1049, 1978.

    Article  PubMed  CAS  Google Scholar 

  5. Weisburger, J. H., B. S. Reddy, and E. L. Wynder. Colon cancer: Its epidemiology and experimental production. Cancer 40: 2414, 1977.

    Article  PubMed  CAS  Google Scholar 

  6. Cummings, J. H. What is fiber? In: Fiber in Human Nutrition, G. A. Spiller and R. J. Amen (eds.). New York, Plenum Press, 1976, p. 1.

    Chapter  Google Scholar 

  7. Trowell, H. C. Ischemic heart disease and dietary fiber. Am. J. Clin. Nutr. 25: 926, 1972.

    PubMed  CAS  Google Scholar 

  8. Spiller, G. A., G. Fassett-Cornelius, and G. M. Briggs. A new term for plant fibers in nutrition. Am. J. Clin. Nutr. 29: 934, 1975.

    Google Scholar 

  9. Kay, R. M., and S. M. Strasberg. Origin, chemistry, physiological effects and clinical importance of dietary fibre. Clin. Invest. Med. 1: 9, 1978.

    PubMed  CAS  Google Scholar 

  10. Freeman, H. J. Dietary fiber and colonic neoplasia. Can. Med. Assoc. J. 121: 291–296, 1979.

    PubMed  CAS  Google Scholar 

  11. Malhotra, S. L. Geographic distribution of gastrointestinal cancers in India with special reference to causation. Gut 8: 361, 1967.

    Article  PubMed  CAS  Google Scholar 

  12. Burkitt, D. P. Epidemiology of cancer of the colon and rectum. Cancer 28: 3, 1971.

    Article  PubMed  CAS  Google Scholar 

  13. Burkitt, D. P., A. R. P. Walker, and N. S. Painter. Effect of dietary fiber in stools and transit times, and its role in the causation of disease. Lancet 2: 1408, 1972.

    Article  PubMed  CAS  Google Scholar 

  14. Walker, A. R. P., and D. P. Burkitt. Colonic cancer — hypothesis of causation, dietary prophylaxis, and future research. Am. J. Dig. Dis. 21: 910, 1976.

    Article  PubMed  CAS  Google Scholar 

  15. Modan, B., V. Barell, F. Lubin, M. Modan, R. A. Greenberg, and S. Graham. Low fiber intake as an etiologic factor in cancer of the colon. J. Natl. Cancer Inst. 55: 15, 1975.

    PubMed  CAS  Google Scholar 

  16. Dales, L. G., G. D. Friedman, H. K. Ury, S. Grossman, and S. R. Williams. A case-control study of relationships of diet and other traits to colorectal cancer in American blacks. Am. J.Epidemol. 109: 132, 1979.

    CAS  Google Scholar 

  17. International Agency for Research on Cancer Intestinal Microecology Group. Dietary fiber, transit-time, fecal bacteria, steroids, and colon cancer in two Scandanavian populations. Lancet 2: 207, 1977.

    Google Scholar 

  18. Eastwood, M. A., and W. D. Mitchell. Physical properties of fiber: A biological evaluation. In: Fiber in Human Nutrition, G. A. Spiller and R. J. Amen (eds.). New York, Plenum Press, 1976, p. 109.

    Chapter  Google Scholar 

  19. Saunders, R. M. Wheat bran: Composition and digestibility. In: Topics in Dietary Fiber Research, G. A. Spiller (ed.). New York, Plenum Press, 1978, p. 43.

    Chapter  Google Scholar 

  20. Southgate, D. A. T. Determination of carbohydrates in foods. II. Unavailable carbohydrates. J. Sci. Food Agric. 20: 331, 1969.

    Article  PubMed  CAS  Google Scholar 

  21. Southgate, D. A. T. The analysis of dietary fiber. In: Fiber in Human Nutrition, G. A. Spiller and R. J. Amen (eds.). New York, Plenum Press, 1976, p. 73.

    Chapter  Google Scholar 

  22. van Soest, P. J. Use of detergents in the analysis of fibrous feeds. J. Assoc. Off. Agric. Chem. 46: 825, 1963.

    Google Scholar 

  23. van Soest, P. J., and R. H. Wine. Method for determination of lignin, cellulose and silica. J. Anim. Sci. 26: 940, 1967.

    Google Scholar 

  24. Lorenz, E., and H. L. Stewart. Intestinal carcinoma and other lesions in mice following oral administration of 1,2,5,6-dibenzanthracene and 20-methylcholanthrene. J. Natl. Cancer Inst. 1: 17, 1941.

    Google Scholar 

  25. Homburger, F., S. S. Hsuek, C. S. Kerr, and A. B. Russfield. Inherited susceptibility of inbred strains of Syrian hamsters to induction of subcutaneous sarcomas and mammary and gastrointestinal carcinomas by subcutaneous and gastric administration of polynuclear hydrocarbons. Cancer Res. 32: 360, 1972.

    PubMed  CAS  Google Scholar 

  26. Walpole, A. L., M. Williams, and D. C. Robert. The carcinogenic action of 4-aminodi-phenyl and 3: 2′-dimethyl-4-aminodiphenyl. Br. J. Ind. Med. 9: 255, 1952.

    PubMed  CAS  Google Scholar 

  27. Cleveland, J. C., S. F. Litvak, and J. W. Cole. Identification of the route of action of the carcinogen 3: 2′-dimethyl-4-aminobiphenyl in the induction of intestinal neoplasia. Cancer Res. 27: 708, 1967.

    PubMed  CAS  Google Scholar 

  28. Laqueur, G. L., O. Mickelson, M. G. Whiting, and L. T. Kurland. Carcinogenic properties of nuts from Cycas circinalis, indigenous to Guam. J. Natl. Cancer Inst. 31: 919, 1963.

    PubMed  CAS  Google Scholar 

  29. Laqueur, G. The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone. Virchows Arch. (Pathol. Anat.) 340: 151, 1965.

    Article  CAS  Google Scholar 

  30. Druckrey, H., R. Preussmann, F. Matzkies, and S. Ivankovic. Selektive Erzeugung von Darmkrebs bei Ratten durch 1,2-Dimethylhydrazin. Naturwissenschaften 54: 285, 1967.

    Article  PubMed  CAS  Google Scholar 

  31. Narisawa, T., T. Sato, M. Hayakawa, A. Sakuma, and H. Nakano. Carcinoma of the colon and rectum of rats by rectal infusion of N-methyl-N-nitro-N-nitrosoguanidine. Gann 62: 231, 1971.

    PubMed  CAS  Google Scholar 

  32. Newberne, P. M., and A. Rogers. Rat colon carcinomas associated with aflatoxin amd marginal vitamin A. J. Natl. Cancer Inst. 50: 439, 1973.

    PubMed  CAS  Google Scholar 

  33. Harris, P. N., W. R. Gibson, and R. D. Dillard. The oncogenicity of two l,l-diaryl-2-pro-pynyl-N-cycloalkyl-carbamates. Cancer Res. 30: 2952, 1970.

    PubMed  CAS  Google Scholar 

  34. Evans, I. A., and J. Mason. Carcinogenic activity of bracken. Nature 208: 913, 1965.

    Article  PubMed  CAS  Google Scholar 

  35. Hirono, I., C. Shibuya, K. Fushimi, and M. Haga. Studies on carcinogenic properties of bracken, Pteridium aquilinum. J. Natl. Cancer Inst. 45: 179, 1970.

    PubMed  CAS  Google Scholar 

  36. Lisco, H., A. M. Brues, M. P. Finker, and W. Grundhauser. Carcinoma of the colon in rats following the feeding of radioactive yttrium. Cancer Res. 7: 721, 1947.

    Google Scholar 

  37. Denman, D. L., F. R. Kirschner, and J. W. Osborne. Induction of colonic adenocarcinoma in the rat by x-irradiation. Cancer Res. 38: 1899, 1978.

    PubMed  CAS  Google Scholar 

  38. Lingeman, C. H., and F. M. Garner. Comparative study of intestinal adenocarcinomas of animals and man. J. Natl. Cancer Inst. 48: 325, 1972.

    PubMed  CAS  Google Scholar 

  39. Winneker, R. C., M. Tompkins, P. Westenberger, and J. Harris. Morphological studies of chemically induced colon tumors in hamsters. Exp. Mol. Pathol. 27: 19, 1977.

    Article  PubMed  CAS  Google Scholar 

  40. Thurnherr, N., E. Deschner, E. Stonehill, and M. Lipkin. Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine. Cancer Res. 33: 940, 1973.

    PubMed  CAS  Google Scholar 

  41. Druckrey, H. Production of colonic carcinomas by 1,2-dialkyl-hydrazines and azoxy-alkanes. In: Carcinoma of the Colon and Antecedent Epithelium, W. J. Burdette (ed.). Springfield, Illinois, Thomas, 1970, p. 267.

    Google Scholar 

  42. Martin, M. S., F. Martin, E. Justrabo, J. F. Knopf, H. Bastien, and S. Knobel. Induction de cancers coliques chez le rat par injection unique de 1,2-dimethyl-hydrazine. Biol. Gastroenterol. 7: 37, 1974.

    CAS  Google Scholar 

  43. Spatz, M., and G. Laqueur. Transplacental induction of tumors in Spraque-Dawley rats with crude cycad material. J. Natl. Cancer Inst. 38: 233, 1967.

    PubMed  CAS  Google Scholar 

  44. Druckrey, H., and A. Lange. Carcinogenicity of azoxymethane dependent on age in BD rats. Fed. Proc. 31: 1482, 1972.

    PubMed  CAS  Google Scholar 

  45. Moon, R. C., C. M. Fricks, and L. J. Schiff. Effect of age and sex on colon carcinogenesis. Proc. Am. Assoc. Cancer Res. 17: 23, 1976.

    Google Scholar 

  46. Evans, J. T., T. B. Shows, E. E. Sproul, N. S. Paloini, and A. Mittelman. Genetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine. Cancer Res. 37: 134, 1977.

    PubMed  CAS  Google Scholar 

  47. Balish, E., C. N. Shih, W. A. Croft, A. M. Pamukcu, G. Lower, G. T. Bryan, and C. E. Yale. Effect of age, sex, and intestinal flora on the induction of colon tumors in rats. J. Natl. Cancer Inst. 58: 1103, 1977.

    PubMed  CAS  Google Scholar 

  48. Diwan, B. A., H. Meier, and K. E. Blackman. Genetic differences in the induction of colorectal tumors by 1,2-dimethylhydrazine in inbred mice. J. Natl. Cancer. Inst. 59: 455, 1977.

    Google Scholar 

  49. Lamont, J. T., and T. A. O’Gorman. Experimental colon cancer. Gastroenterology 75: 1157, 1978.

    PubMed  CAS  Google Scholar 

  50. Miwa, M., S. Takenaka, K. Ito, K. Fujiwara, K. Kogure, A. Tokunaga, M. Hozumi, S. Fujimura, and T. Sugimura. Spontaneous colon tumors in rats. J. Natl. Cancer Inst. 56: 615, 1976.

    PubMed  CAS  Google Scholar 

  51. Pozharisski, K. M. Tumors of the intestines. IARC Sci. Public. 5: 119, 1973.

    CAS  Google Scholar 

  52. Heslop, B. F. Cystic adenocarcinoma of the ascending colon in rats occurring as a self-limiting outbreak. Lab. Anim. 3: 185, 1969.

    Article  Google Scholar 

  53. Weisburger, E. K. Mechanisms of chemical carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 18: 395, 1978.

    Article  PubMed  CAS  Google Scholar 

  54. Weisburger, J. H. Colon carcinogens: Their metabolism and mode of action. Cancer 28: 60, 1971.

    Article  PubMed  CAS  Google Scholar 

  55. Fiala, E. S. Investigations into the metabolism and mode of action of the colon carcinogen 1,2-dimethylhydrazine. Cancer 36: 2407, 1975.

    Article  PubMed  CAS  Google Scholar 

  56. Fiala, E. S., C. Kulakis, G. Bobotas, and J. H. Wiesburger. Detection and estimation of azomethane in expired air of 1,2-dimethylhydrazine-treated rats. J. Natl. Cancer Inst. 56: 1271, 1976.

    PubMed  CAS  Google Scholar 

  57. Nagasasawa, H. T., F. N. Shirota, and H. Matsumoto. Decomposition of methylazoxy-methanol the aglycone of cycasin in D2O Nature 236: 234, 1972.

    Article  Google Scholar 

  58. Grab, D. J., and M. S. Zedek. Organ-specific effects of the carcinogen methylazoxymeth-anol related to metabolism by nicotinamide adenine dinucleotide-dependent dehydrogenases. Cancer Res. 37: 4182, 1977.

    PubMed  CAS  Google Scholar 

  59. Matsumoto, H., and H. H. Higa, Studies on methylazoxymethanol, the aglycone of cycasin: Methylation of nucleic acids in vitro. Biochem. J. 98: 20, 1966.

    Google Scholar 

  60. Pozharisski, K. M., Y. M. Kapustin, A. J. Likhachev, and J. D. Shaposhnikov. The mechanism of carcinogenic action of 1,2-dimethylhydrazine in rats. Int. J. Cancer 15: 673, 1975.

    Article  PubMed  CAS  Google Scholar 

  61. Laqueur, G. L. Carcinogenic effects of cycad meal and cycasin, methylazoxymethanol glycoside, in rats and effects of cycasin in germfree rats. Fed. Proc. 23: 1386, 1964.

    PubMed  CAS  Google Scholar 

  62. Reddy, B. S., T. Narisawa, P. Wright, D. Vukusich, J. H. Weisburger, and E. L. Wynder. Colon carcinogenesis with azoxymethane and dimethylhydrazine in germ-free rats. Cancer Res. 35: 287, 1975.

    PubMed  CAS  Google Scholar 

  63. Reddy, B. S., T. Narisawa, and J. H. Weisburger. Colon carcinogenesis in germ-free rats with intrarectal 1,2-dimethylhydrazine and subcutaneous azoxymethane. Cancer Res. 36: 2874, 1975.

    Google Scholar 

  64. Zedek, M. S., D. J. Grab, and S. S. Sternberg. Differences in the acute response of the various segments of rat intestine to treatment with the intestinal carcinogen methylazoxy-methanol acetate. Cancer Res. 37: 32, 1977.

    Google Scholar 

  65. Toth, B. The large-bowel carcinogenic effects of hydrazines and related compounds occurring in nature and the environment. Cancer 40: 2427, 1977.

    Article  PubMed  CAS  Google Scholar 

  66. Toth, B. Synthetic and naturally occurring hydrazines as possible cancer causative agents. Cancer Res. 35: 3693, 1975.

    PubMed  CAS  Google Scholar 

  67. Liu, Y. Y., I. Schmeltz, and D. Hoffman. Chemical studies on tobacco smoke. Quantitative analysis of hydrazine in tobacco and cigarette smoke. Anal. Chem. 46: 885, 1974.

    Article  PubMed  CAS  Google Scholar 

  68. Handbook on California Toxic Fungi, San Francisco Mycological Society, San Francisco, 1977.

    Google Scholar 

  69. Nagel, D., B. Toth, and L. Wallcave. Formation of methylhydrazine from acetaldehyde-Nmethyl-Nformylhydrazine, a component of Gyromitra esculenta. Cancer Res. 37: 3458, 1977.

    PubMed  CAS  Google Scholar 

  70. The Merck Index. Eighth Edition. Rahway, N.J., Merck and Co., Inc., 1968.

    Google Scholar 

  71. Gowing, P. P., and R. W. Leeper. Induction of flowering in pineapple by beta-hydroxy-ethylhydrazine. Science 122: 1267, 1955.

    Article  CAS  Google Scholar 

  72. Ward, J. M., R. S. Yamamoto, and C. A. Brown. Pathology of intestinal neoplasms and other lesions in rats exposed to azoxymethane. J. Natl. Cancer Inst. 51: 1029, 1973.

    PubMed  CAS  Google Scholar 

  73. Ward, J. M. Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats. Lab. Invest. 30: 505, 1974.

    PubMed  CAS  Google Scholar 

  74. Pozharisski, K. M. Morphology and morphogenesis of experimental epithelial tumors of the intestine. J. Natl. Cancer Inst. 54: 1115, 1975.

    PubMed  CAS  Google Scholar 

  75. Freeman, H. J., G. A. Spiller, and Y. S. Kim. A double-blind study on the effect of purified cellulose dietary fiber on 1,2-dimethylhydrazine-induced rat colonic neoplasia. Cancer Res. 38: 2912, 1978.

    PubMed  CAS  Google Scholar 

  76. Freeman, H. J., Y. W. Kim, and Y. S. Kim. Glycoprotein metabolism in normal proximal and distal rat colon and changes assciated with 1,2-dimethylhydrazine-induced colonic neoplasia. Cancer Res. 38: 3385, 1978.

    PubMed  CAS  Google Scholar 

  77. Lindstrom, C. G. Experimental colorectal tumours in the rat. Acta Pathol. Microbiol. Scand. Sect. A Suppl. 268: 1, 1978.

    Google Scholar 

  78. Freeman, H. J., M. E. Etzler, A. B. Garrido, and Y. Kim. Alterations in cell surface membrane components of adapting rat small intestinal epithelium. Gastroenterology 75: 1066, 1978.

    PubMed  CAS  Google Scholar 

  79. Sharon, N. and H. Lis. Lectins: Cell-agglutinating and sugar-specific proteins. Science 177: 949, 1972.

    Article  PubMed  CAS  Google Scholar 

  80. Filipe, M. I., and A. C. Branfoot. Mucin histochemistry of the colon. In: Pathology of the Gastrointestinal Tract, B. C. Morson (ed.). Berlin, Springer-Verlag, 1976, p. 143.

    Chapter  Google Scholar 

  81. Filipe, M. I. Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. A morphological and histochemical study. Br. J. Cancer 32: 60, 1975.

    Article  PubMed  CAS  Google Scholar 

  82. Morson, B. C., and L. H. Sobin. Histological Typing of Intestinal Tumors. Geneva, World Health Organization, 1976.

    Google Scholar 

  83. Morson, B. C. The polyp-cancer sequence in the large bowel. Proc. R. Soc. Med. 67: 451, 1974.

    PubMed  CAS  Google Scholar 

  84. Morson, B. C., and H. J. R. Bussey. Predisposing Causes of Intestinal Cancer. Chicago, Yearbook Medical Publishers, 1970.

    Google Scholar 

  85. Toth, B., and L. Malick. Production of intestinal and other tumors by 1,2-dimethylhydrazine dihydrochloride in mice. II. Scanning electron microscopic and cytochemical study of colonic neoplasms. Br. J. Exp. Pathol. 57: 696, 1976.

    PubMed  CAS  Google Scholar 

  86. Barkla, D. H., and P. J. Tutton. Surface changes in the descending colon of rats treated with dimethylhydrazine. Cancer Res. 37: 262, 1977.

    PubMed  CAS  Google Scholar 

  87. Lamont, J. T., M. M. Weiser, and K. J. Isselbacher. Cell surface glycosyltransferase activity in normal and neoplastic intestinal epithelium of the rat. Cancer Res. 34: 3225, 1974.

    PubMed  CAS  Google Scholar 

  88. Weiser, M. M. Intestinal epithelial cell membrane glycoprotein synthesis. J. Biol. Chem. 248: 2536, 1973.

    PubMed  CAS  Google Scholar 

  89. Lamont, J. T., and K. J. Isselbacher. Alterations in glycosyltransferase in human colon cancer. J. Natl. Cancer Inst. 54: 53, 1975.

    PubMed  CAS  Google Scholar 

  90. Kim, Y. S., and R. Isaacs. Glycoprotein metabolism in inflammatory and neoplastic disease of the human colon. Cancer Res. 35: 2092, 1975.

    PubMed  CAS  Google Scholar 

  91. Wilson, R. B., D. P. Hutcheson, and L. Wideman. Dimethylhydrazine-induced colon tumors in rats fed diets containing beef fat or corn oil with and without wheat bran. Am. J.Clin. Nutr. 30: 176, 1977.

    PubMed  CAS  Google Scholar 

  92. Barbolt, T. A., and R. Abraham. The effect of bran on dimethylhydrazine-induced colon carcinogenesis in the rat. Proc Soc. Exp. Biol. Med. 157: 656, 1978.

    PubMed  CAS  Google Scholar 

  93. Chen, W. F., A. S. Patchefsky, and H. S. Goldsmith. Colonic protection from dimethylhydrazine by a high fiber diet. Surg. Gynecol. Obstet. 147: 503, 1978.

    PubMed  CAS  Google Scholar 

  94. Fleiszer, D., D. Murray, J. Macfarlane, and R. A. Brown. Protective effect of dietary fibre against chemically induced bowel tumors in rats. Lancet 2: 552, 1978.

    Article  PubMed  CAS  Google Scholar 

  95. Cruse, J. P., M. R. Lewin, and C. G. Clarke. Failure of bran to protect against colon cancer in rats. Lancet 2: 1278, 1978.

    Article  PubMed  CAS  Google Scholar 

  96. Ward, J. M., R. S. Yamamoto, and J. H. Weisburger. Cellulose dietary bulk and azoxy-methane-induced intestinal cancer. J. Natl. Cancer Inst. 51: 713, 1973.

    PubMed  CAS  Google Scholar 

  97. Watanabe, K., B. S. Reddy, C. Q. Wong, and J. H. Weisburger. Effect of dietary unde-graded carrageenan on colon carcinogenesis in F344 rats treated with azoxymethane or methylnitrosourea. Cancer Res. 38: 4427, 1978.

    PubMed  CAS  Google Scholar 

  98. Carachi, R., A. Busutill, and S. N. Joffe. Influence of high and low fibre diet on induction of colorectal tumors in the rat using dimethylhydrazine HCl. Gut 18: 410, 1977.

    Google Scholar 

  99. Carachi, R., A. Busutill, and S. N. Joffe. Dietary fiber and colorectal cancer. Scott. Med. J. 22: 743, 1977.

    Google Scholar 

  100. Freeman, H. J., Y. Kim, and G. A. Spiller. Effect of chemically defined dietary fiber on rat colonic neoplasia induced by 1,2-dimethylhydrazine. Gastroenterology 74: 1036, 1978.

    Google Scholar 

  101. Watanabe, K., B. S. Reddy, D. Kritchevsky, and C. G. Clark. Effect of various dietary fibers and additives on azoxymethane or methylnitrosourea-induced colon carcinogenesis in rats. Fed. Proc. 37: 262, 1978.

    Google Scholar 

  102. Cruse, J. P., M. R. Lewin, G. P. Ferrulano, and C. G. Clark. Dietary fiber, vivonex cholesterol and experimental colon cancer. Gut 18: 983, 1978.

    Google Scholar 

  103. Fleiszer, D., D. Murray, and R. A. Brown. The effect of a chemically-defined diet, vitamin A and graded fiber on chemically induced bowel cancer. Ann. R. Coll. Phys. Surg. Can. 122: 52, 1979.

    Google Scholar 

  104. Saunders, R. M. Wheat bran: Composition and digestibility. In: Topics in Dietary Fiber Research, G. A. Spiller (ed.). New York, Plenum Press, 1978, p. 43.

    Chapter  Google Scholar 

  105. Alcantera, E. N., and E. W. Speckmann. Diet, nutrition and cancer. Am. J. Clin. Nutr. 29: 1035, 1976.

    Google Scholar 

  106. Freeman, H. J., Y. S. Kim, and G. A. Spiller. Unpublished data, 1977.

    Google Scholar 

  107. Marcus, R., and J. Watt. Colonic ulceration in young rats fed degraded carrageenan. Lancet 2: 765, 1971.

    Article  PubMed  CAS  Google Scholar 

  108. Watt, J., and R. Marcus. Carrageenan-induced ulceration of the large intestine in the guinea pig. Gut 12: 164, 1971.

    Article  PubMed  CAS  Google Scholar 

  109. Watt, J., and R. Marcus. Hyperplastic mucosal changes in the rabbit colon produced by degraded carrageenan. Gastroenterology 59: 760, 1970.

    PubMed  CAS  Google Scholar 

  110. Pozharisski, K. M. The significance of nonspecific injury for colon carcinogenesis in rats. Cancer Res. 35: 3824, 1975.

    PubMed  CAS  Google Scholar 

  111. Fabian, R. J., R. Abraham, F. Coulston, and L. Golberg. Carrageenan-induced squamous metaplasia of the rectal mucosa in the rat. Gasteroenterology 65: 265, 1973.

    CAS  Google Scholar 

  112. Wakabayashi, K., T. Inagaki, Y. Fujimoto, and Y. Fukuda. Induction by degraded carrageenan of colorectal tumors in rats. Cancer Lett. 4: 171, 1978.

    Article  Google Scholar 

  113. Spiller, G. A. Interaction of dietary fiber with other dietary components: A possible factor in certain cancer etiologies. Am. J. Clin. Nutr. 31: 5231, 1978.

    Google Scholar 

  114. Salyers, A. A., J. K. Palmer, and T. D. Wilkins. Degradation of polysaccharides by intestinal bacterial enzymes. Am. J. Clin. Nutr. 31:S128, 1978.

    Google Scholar 

  115. Holloway, W. D., C. Tasman-Jones, and S. P. Lee. Digestion of certain fractions of dietary fiber in humans. Am. J. Clin. Nutr. 31: 927, 1978.

    PubMed  CAS  Google Scholar 

  116. Finegold, S. M., H. R. Attebery, and V. L. Sutter. Effect of diet on human fecal flora: Comparison of Japanese and American diets. Am. J. Clin. Nutr. 29: 1456, 1974.

    Google Scholar 

  117. Finegold, S. M., and V. L. Sutter. Fecal flora in different populations, with special reference to diet. Am. J. Clin. Nutr. 31:S116, 1978.

    Google Scholar 

  118. Fuchs, H. M., S. Dorfman, and M. H. Flock. The effect of dietary fiber supplementation in man. II. Alteration in fecal physiology and bacterial flora. Am. J. Clin. Nutr. 29: 1443, 1976.

    Google Scholar 

  119. Mastromarino, A., B. S. Reddy, and E. L. Wynder. Metabolic epidemiology of colon cancer: Enzymic study of fecal flora. Am. J. Clin. Nutr. 29: 1455, 1976.

    PubMed  CAS  Google Scholar 

  120. Goldin, B., J. Dwyer, S. L. Gorbach, W. Gordon, and L. Swenson. Influence of diet and age on fecal bacterial enzymes. Am. J. Clin. Nutr. 31:S136, 1978.

    CAS  Google Scholar 

  121. Eastwood, M. A., and W. D. Mitchell. Physical properties of fiber: A biological evaluation. In: Fiber in Human Nutrition, G. A. Spiller and R. J. Amen (eds.). New York, Plenum Press, 1976, p. 109.

    Chapter  Google Scholar 

  122. Lewis, B. A. Physical and biological properties of structural and other nondigestible carbohydrates. Am. J. Clin. Nutr. 31:S82, 1978.

    CAS  Google Scholar 

  123. Branch, W. J., D. A. T. Southgate, and W. P. T. James. Binding of calcium by dietary fiber: Its relationship to unsubstituted uronic acids. Proc. Nutr. Soc. 34: 120, 1975.

    Google Scholar 

  124. Luther, L., R. Santini, E. Brewster, E. Perez-Santiago, and C. E. Butterworth. Folate binding by insoluble components of American and Puerto Rican diets. Ala. J. Med. Sci. 3: 389, 1965.

    Google Scholar 

  125. Eastwood, M. A., and D. Hamilton. Studies on the absorption of bile salts to non-absorbed components of the diet. Biochim. Biophys. Acta 152: 165, 1968.

    PubMed  CAS  Google Scholar 

  126. Eastwood, M. A., and R. H. Girdwood. Lignin. A bile-salt sequestering agent. Lancet 2: 1170, 1968.

    Article  PubMed  CAS  Google Scholar 

  127. Huang, C. T. L., G. S. Gopalakrishna, and B. L. Nichols. Fiber, intestinal sterols, and colon cancer. Am. J. Clin. Nutr. 31: 516, 1978.

    PubMed  CAS  Google Scholar 

  128. Lin, T. M., K. S. Kim, E. Karvinen, and A. C. Ivy. Effect of dietary pectin,“proto-pectin”and gum arabic on cholesterol excretion in rats. Am. J. Physiol. 158: 66, 1967.

    Google Scholar 

  129. Southgate, D. A. T., and J. V. G. Durnin. Caloric conversion factors. An experimental reassessment of the factors used in the calculation of the energy value of human diets. Br. J. Nutr. 24: 517, 1970.

    Article  PubMed  CAS  Google Scholar 

  130. Kern, F., H. J. Birkner, and V. S. Ostrower. Binding of bile acids by dietary fiber. Am. J. Clin. Nutr. 31:S175, 1978.

    Google Scholar 

  131. Sandstead, H. H., J. M. Munoz, R. A. Jacob, L. M. Klevay, S. J. Reck, G. M. Logan, Jr., F. D. Dintzis, G. E. Inglett, and W. C. Shuey. Influence of dietary fiber on trace element balance. Am. J. Clin. Nutr. 31:S180, 1978.

    CAS  Google Scholar 

  132. Land, P. C., and W. R. Bruce. Fecal mutagens: A possible relationship with colorectal cancer. Proc. Am. Assoc. Cancer Res. 19: 167, 1978.

    Google Scholar 

  133. Tannenbaum, S. R., D. Fett, V. R. Young, P. D. Land, and W. R. Bruce. Nitrite and nitrate are formed by endogenous synthesis in the human intestine. Science 200: 1487, 1978.

    Article  PubMed  CAS  Google Scholar 

  134. Devroede, G. Dietary fiber, bowel habits and colonic function. Am. J. Clin. Nutr. 31:S157, 1978.

    Google Scholar 

  135. Cleveland, J. C., and J. W. Cole. Relationship of experimentally induced intestinal tumors to laxative ingestion. Cancer 33: 1200, 1969.

    Article  Google Scholar 

  136. Portmann, O. W. Nutritional influences on the metabolism of bile acids. Am. J. Clin. Nutr. 8: 462, 1960.

    Google Scholar 

  137. Pomare, E. W., and K. W. Heaton. Alteration of bile salt metabolism by dietary fibre (bran). Br. Med. J. 4: 262, 1973.

    Article  PubMed  CAS  Google Scholar 

  138. Kritchevsky, D., and J. A. Story. Binding of bile salts in vitro by non-nutritive fiber. J. Nutr. 104: 458, 1974.

    PubMed  CAS  Google Scholar 

  139. Balmer, J., and D. B. Zilversmit. Effect of dietary roughage on cholesterol absorption, cholesterol turnover and steroid excretion in the rat. J. Nutr. 104: 1319, 1974.

    PubMed  CAS  Google Scholar 

  140. Story, J. A., and D. Kritchevsky. Comparison of the binding of various bile acids and bile salts in vitro by several types of fiber. J. Nutr. 106: 1292, 1976.

    PubMed  CAS  Google Scholar 

  141. Eastwood, M. A., and L. Mowbray. The binding of the components of mixed micelle to dietary fiber. Am. J. Clin. Nutr. 29: 1461, 1976.

    PubMed  CAS  Google Scholar 

  142. Story, J. A., and D. Kritchevsky. Bile-acid metabolism and fiber. Am. J. Clin. Nutr. 31:S199, 1978.

    Google Scholar 

  143. Reddy, B. S., and E. L. Wynder. Large-bowel carcinogenesis: Fecal constituents of populations with diverse incidence rates of colon cancer. J. Natl. Cancer Inst. 50: 1437, 1973.

    PubMed  CAS  Google Scholar 

  144. Hill, M. J., B. S. Drasar, V. Aries, J. S. Crowther, G. Hawksworth, and R. E. O. Williams. Bacteria and etiology of cancer of large bowel. Lancet 1: 95, 1971.

    Article  PubMed  CAS  Google Scholar 

  145. Cook, J. W., and G. A. Haslewood. Conversion of a bile acid into a hydrocarbon derived from 1,2-benzanthracene. Chem. Ind. 11: 758, 1933.

    Article  Google Scholar 

  146. Goddard, P., and M. J. Hill. Degradation of intestinal sterols by intestinal bacteria. IV. Aromatization of ring A. Biochim. Biophys. Acta 280: 336, 1972.

    PubMed  CAS  Google Scholar 

  147. Savage, D. C. Microbial ecology of the gastrointestinal tract. Annu. Rev. Microbiol. 31: 107, 1977.

    Article  PubMed  CAS  Google Scholar 

  148. Goldin, B. R., and S. L. Gorbach. The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer. J. Natl. Cancer Inst. 57: 371, 1976.

    PubMed  CAS  Google Scholar 

  149. Mastromarino, A. J., B. S. Reddy, and E. L. Wynder. Fecal profiles of anaerobic microflora of large-bowel cancer patients and patients with nonhereditary large-bowel polyps. Cancer Res. 38: 4458, 1978.

    PubMed  CAS  Google Scholar 

  150. Goldin, B., and S. L. Gorbach. Alterations in fecal microflora enzymes related to diet, age, lactobacillus supplements, and dimethylhydrazine. Cancer 40: 2421, 1977.

    Article  PubMed  CAS  Google Scholar 

  151. Wattenberg, L. W. Inhibition of chemical carcinogenesis. J. Natl. Cancer Inst. 60: 11, 1978.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Vancouver General Hospital, Canada

    Hugh James Freeman

  2. Gastrointestinal Cancer and Nutrition Laboratory, Environmental Carcinogenesis Unit, University of British Columbia Cancer Research Center, Vancouver, British Columbia, Canada

    Hugh James Freeman

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  1. Syntex Research, Palo Alto, California, USA

    Gene A. Spiller

  2. University of Toronto, Toronto, Ontario, Canada

    Ruth McPherson Kay

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© 1980 Plenum Publishing Corporation

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Freeman, H.J. (1980). Experimental Animal Studies in Colonic Carcinogenesis and Dietary Fiber. In: Spiller, G.A., Kay, R.M. (eds) Medical Aspects of Dietary Fiber. Topics in Gastroenterology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9176-4_6

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  • DOI: https://doi.org/10.1007/978-1-4615-9176-4_6

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