Skip to main content

Micropuncture Study of Distal Tubular Activation of Phosphate Reabsorption in the Rat

  • Chapter
Phosphate and Minerals in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 128))

Abstract

A considerable body of evidence suggests a reciprocal relationship between the urinary excretion rate of potassium and urinary pH1. In addition, attention has also been drawn to a reciprocal relationship between potassium and ammonium excretion2,3. The relationship between the excretion rate of urinary buffers, mainly phosphate, and potassium, is less well defined. In order to evaluate this aspect of renal tubular acidification, micropuncture studies were carried out in which the effects of acute potassium loading upon phosphate transport were investigated.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R.W. Berliner, Renal mechanisms for potassium excretion. Harvey Lect. 55: 141.

    Google Scholar 

  2. R.L. Tannen, Relationship of renal ammonia production and potassium homeostasis. Kidney Int. 11: 453 (1977).

    Article  PubMed  CAS  Google Scholar 

  3. Ph. Jaeger, B. Karlmark, and G. Giebisch, Micropuncture study of relationship between K+ and tubular acidification. KidneyInt. 12:562 (1977) (Abstr.).

    Google Scholar 

  4. J. Diezi, P. Michoud, A. Grandchamp, and G. Giebisch, Effect of nephrectomy on renal salt and water transport in the remaining kidney. Kidney Int. 10: 450 (1976).

    Article  PubMed  CAS  Google Scholar 

  5. P.S. Chen, Jr., T.Y. Toribara, and H. Warner, Microdetermination of phosphorus. Anal. Chem. 28: 11: 1756 (1956).

    Google Scholar 

  6. Ph. Jaeger, B. Karlmark, B. Stanton, R.G. Kirk, T. Duplinsky, and G. Giebisch, Manuscript in preparation.

    Google Scholar 

  7. B. Karlmark, The determination of titratable acid and ammonium ions in picomole amounts. Anal. Biochem. 52: 69 (1973).

    Article  PubMed  CAS  Google Scholar 

  8. B. Karlmark, Ph. Jaeger, and G. Giebisch, Coulometric acid-base titration in nanoliter samples with glass and antimony electrodes. A technical description. Manuscript in preparation.

    Google Scholar 

  9. J. Lemann, Jr., E.J. Lennon, J. Brock, A potential error in the measurement of urinary titratable acid. J. Lab. Clin. Med. 67: 906 (1966).

    PubMed  Google Scholar 

  10. C. Amiel, H. Kuntziger, S. Couette, C. Coureau, N. Bergounioux, Evidence for a parathyroid independent calcium modulation of phosphate transport along the nephron. J. Clin. Invest. 57: 256 (1976).

    Article  PubMed  CAS  Google Scholar 

  11. L.H. Beck, M. Goldberg, Mechanism of the blunted phosphaturia in saline-loaded thyroparathyroidectomized dogs. Kidney Int. 6: 18 (1974).

    Google Scholar 

  12. G. Malnic, and G. Giebisch, Micropuncture study of renal potassium excretion in the rat. Am. J. Physiol. 206: 674 (1964).

    PubMed  CAS  Google Scholar 

  13. K. Baumann, G. Rumrich, G., F. Papavassiliou, and S. Kloss, pH dependence of phosphate reabsorption in the proximal tubule of rat kidney. Pflügers Arch. 360: 183 (1975).

    Google Scholar 

  14. N. Bank, H. Aynedjian, and S.W. Weinstein, A microperfusion study of phosphate reabsorption by the rat proximal renal tubule. J. Clin. Invest. 54: 1040 (1974).

    Article  PubMed  CAS  Google Scholar 

  15. H. Murer, Transport of phosphate by rat proximal tubular brush border vesicles. Presentation at the 4th International Workshop on Phosphate and Other Minerals, Strasbourg, 1979.

    Google Scholar 

  16. S. Adler, and D.S. Fraley, Potassium and intracellular pH. Kidney Int. 11: 433 (1977).

    Article  PubMed  CAS  Google Scholar 

  17. R.K. Webb, Ph.B. Woodhall, C. Tischer, G. Glaubiger, F.A. Neelon, and R.R. Robinson, Relationship between phosphaturia and acute hypercapnia in the rat. J. Clin. Invest. 60: 829 (1977).

    Article  PubMed  CAS  Google Scholar 

  18. J.C.M. Chan, and F.C. Bartter, Effect of acidosis and alkalosis on calcium and phosphorus metabolism in normal man. MineralandElectrolyteMetabolism 2:214 (1979) Abstract.

    Google Scholar 

  19. K.J. Ullrich, G. Rumrich, S. Kloss, Phosphate transport in the proximal convolution of the rat kidney. Pflügers Arch. 377: 33 (1978).

    Article  PubMed  CAS  Google Scholar 

  20. R.A. DeFronzo, M. Goldberg, and Z. Agus, The effects of glucose and insulin on renal electrolyte transport. J. Clin. Invest. 58: 83 (1976).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Press, New York

About this chapter

Cite this chapter

Jaeger, P., Karlmark, B., Stanton, B., Kirk, R.G., Duplinsky, T., Giebisch, G. (1980). Micropuncture Study of Distal Tubular Activation of Phosphate Reabsorption in the Rat. In: Massry, S.G., Ritz, E., Jahn, H. (eds) Phosphate and Minerals in Health and Disease. Advances in Experimental Medicine and Biology, vol 128. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9167-2_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9167-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9169-6

  • Online ISBN: 978-1-4615-9167-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics