Abstract
When growing rats are restricted to a diet very low in phosphate, they develop hypophosphatemia, hypercalcemia, hypercalciuria and almost complete suppression of phosphate excretion in the urine and there is progressive loss of calcium and phosphate from the skeleton1,2,3. There would appear to be potent homeostatic mechanisms to ensure a supply of phosphate for the growing soft tissues. Since hypophosphatemia stimulates the synthesis of the active metabolite of vitamin D3, 1,25 dihydroxycholecalciferol,4 the question arises as to whether vitamin D is essential for the homeostatic changes associated with severe phosphate deprivation. The following studies were carried out on young chicks, which are particularly sensitive to the effects of vitamin D.
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References
Day, H.G., and McCollum, E.V., 1939, Mineral metabolism, growth and symptomatology of rats on a diet extremely deficient in phosphorus, J.Biol.Chem., 130: 269.
Baylink, D.J., Wergedal, J., and Stauffer, M., 1971, Formation mineralization and resorption of bone in hypophosphatemic rats, J.Clin.Invest., 50: 2519.
Copp, H., 1971, Effets dTun regime pauvre en phosphore sur l’homeostasie du calcium et de l’ion phosphate chez le rat jeune, in: “Phosphate et Metabolisme Phosphocalcique”, D.J. Hioco, ed., Sandoz Publications, Paris.
Tanaka, Y. and DeLuca, H.F., 1973, The control of 25-hydroxy- vitamin D3 metabolism by inorganic phosphate, Arch.Biochem., 154: 566.
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© 1980 Plenum Press, New York
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Copp, D.H., Lang, S.A., Ma, S.W.Y. (1980). Effects of Severe Phosphate Deprivation in Growing Chicks and Possible Role of Vitamin D. In: Massry, S.G., Ritz, E., Jahn, H. (eds) Phosphate and Minerals in Health and Disease. Advances in Experimental Medicine and Biology, vol 128. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9167-2_38
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DOI: https://doi.org/10.1007/978-1-4615-9167-2_38
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9169-6
Online ISBN: 978-1-4615-9167-2
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